Path recall March 2018 Flashcards
- Wilsons likely
a. Baby jaundice 3-6months
b. Corona radiata T2 early in disease
c. High ceruloplasmin bound copper
d. Autosomal dominant
e. Fatty liver
- Wilsons likely
a. Baby jaundice 3-6months - too young usually teens
b. Corona radiata T2 early in disease - usually basal ganglia causing parkinsonism
c. High ceruloplasmin bound copper - low ceruloplasmin high copper
d. Autosomal dominant - AR
e. Fatty liver -true, mix with high density copper in liver may be normal on CT
- SLE part of diagnostic criteria
a. Pericarditis
b. Peripheral neuropathy
c. Erosive arthropathy
a. Pericarditis true
2. SLE part of diagnostic criteria
a. Pericarditis true
b. Peripheral neuropathy - CNS
c. Erosive arthropathy - non erosive
d. MD SOAP BRAIN = criteria for SLE = malar rash, discoid rash, serositis, oral ulcers, arthritis, photosensitivity, blood dyscrasias, renal failure, ANA, immunologic, neurologic
- Xlinked
a. Adrenoleukodystrophy
b. Alexanders
c. Canavan
d. MLD
a. Adrenoleukodystrophy yes
3. Xlinked
a. Adrenoleukodystrophy yes
b. Alexanders
c. Canavan
d. MLD
- FMD doesn’t cause
a. Tinnitis
b. PVD
c. Angina
d. Renal
e. Carotid
**LJS - I think PVD least common of those listed. Tinnitus listed on radiopedia, due to carotid/VA involvement. Rest listed in Robbins, PVD is not in either (though some evidence that it occurs - google)
a. Tinnitis yes but rare, I think rarest only in case series
4. FMD doesn’t cause
a. Tinnitis yes but rare, I think rarest only in case series
b. PVD yes but rare
c. Angina yes but rare in case series
d. Renal
e. Carotid
- PAN does not affect
a. Lungs
b. Kidneys
c. Mesenteric vessels
a. Lungs PAN spares lungs classically, similar to MPA but medium vessels affected
5. PAN does not affect
a. Lungs PAN spares lungs classically, similar to MPA but medium vessels affected
b. Kidneys
c. Mesenteric vessels
- SCC tongue which doesn’t cause
a. Marijuana
b. Cocaine
c. HPV
d. Syphillis
e. Alcohol
b. Cocaine doesn’t because you snort it, HTN, perforation
6. SCC tongue which doesn’t cause
a. Marijuana smoking
b. Cocaine doesn’t because you snort it, HTN, perforation
c. HPV yes oral sex
d. Syphillis rare syphilitic leukoplakia
e. Alcohol yes
- Not risk factor for RCC
a. Smoking
b. Alcohol
c. Obesity
b. Alcohol no! lower risk
7. Not risk factor for RCC
a. Smoking yes
b. Alcohol no! lower risk
c. Obesity yes
- Precursor to melanoma
a. Blue naevus
b. Dysplastic naevus
c. Congenital naevus
d. Basal naevus
b. Dysplastic naevus yes
8. Precursor to melanoma
a. Blue naevus
b. Dysplastic naevus yes
c. Congenital naevus
d. Basal naevus
- PML
a. JCV
- PML
a. JCV yes
- Jaundice in pregnancy, most common cause of liver disease in pregnancy
a. Cholestasis
b. Hepatitis
c. Preeclampsia
d. HELLP
b. Hepatitis yes most common cause of jaundice in pregnancy
10. Jaundice in pregnancy, most common cause of liver disease in pregnancy
a. Cholestasis 1 in 1000
b. Hepatitis yes most common cause of jaundice in pregnancy
c. Preeclampsia HTN and proteinuria
d. HELLP rare but bad
- Least true regarding circumvallate
a. Abruption
b. IUGR
c. Painless bleeding
d. Fetal death
e. Abnormal tocography
c. Painless bleeding
**LJS - anything that increases risk of abruption, IUGR and preterm birth surely also increases risk of fetal death if these things not managed appropriately.
Painless bleeding least likely
*AJL agrees
- Least true regarding circumvallate
a. Abruption
b. IUGR
c. Painless bleeding
d. Fetal death
e. Abnormal tocography
- Least correct
a. ADEM follow bacterial infection
b. NMO bilateral optic neuritis
c. Relapsing remitting MS on MRI plaque doesn’t have axonal degeneration
a. ADEM follow bacterial infection I think this
12. Least correct
a. ADEM follow bacterial infection I think this
b. NMO bilateral optic neuritis
c. Relapsing remitting MS on MRI plaque doesn’t
have axonal degeneration
- Hirschprungs false
a. More common in females
b. Involves whole colon
c. Bowel obstruction and perforation
a. More common in females - more common male
13. Hirschprungs false
a. More common in females more common male
b. Involves whole colon
c. Bowel obstruction and perforation
**LJS - only 4% total aganglionosis
- PXA
a. Involves grey matter and overlying meninges
b. Adults frontal
c. Child brainstem and cerebellum
a. Involves grey matter and overlying meninges this dural reaction
14. PXA
a. Involves grey matter and overlying meninges this dural reaction
b. Adults frontal - temporal
c. Child brainstem and cerebellum - rare
- Which chondroid lesion crosses physes
a. Chondroblastoma
b. Periostial chondroma
c. EnchondromaLeas
d. CMF
e. Osteochondroma
*LW:
Wheeles states: only three tumors may invade physis: chondroblastoma, GCT, and clear cell chondrosarcoma
**LJS - CMF
*AJL (thinks this is a stupid question)
Chondroblastoma starts in epiphysis and crosses physis
CMF starts in metaphysis and crosses physis.
- Which chondroid lesion crosses physes
a. Chondroblastoma rarely may cross physis
b. Periostial chondroma
c. Enchondroma
d. CMF
e. Osteochondroma
- PVNS and GCT false
a. PVNS most common knee
b. GCT most common wrist
c. PVNS and GCT erode bone
d. GCT excision likely to recur
e. PVNS characteristically cause inflammation
*LW: they referring to giant cell tumour of tendon sheath (i.e. same spectrum as PVNS) which is most common in wrist. thus E false
(*AJL. If they were referring to bone GCT then it is most common at the knee)
(as an aside, PVNS is now known as tenosynovial GCT diffuse type. The type in the tendon sheath is tenosynovial GCT localised type. This is in the more recent Robbins 2018 basic and 2020 big robbins)
- PVNS and GCT false
a. PVNS most common knee
b. GCT most common wrist
c. PVNS and GCT erode bone
d. GCT excision likely to recur - 10-20% recurrence
e. PVNS characteristically cause inflammation probably this characteristically bleed other answers are all more correct
- Post partum diabetes insipidus
a. Lymphocytic hypophysitis
b. Sheehans
a. Lymphocytic hypophysitis yes, loss of posterior pituitary bright spot and DI
17. Post partum diabetes insipidus
a. Lymphocytic hypophysitis yes, loss of posterior pituitary bright spot and DI
b. Sheehans massive bleed and necrosis
- Most common with tumor marker
a. YS tumor
b. Seminoma
c. Granulosa cell
a. YS tumor aFP
18. Most common with tumor marker
a. YS tumor aFP
b. Seminoma
c. Granulosa cell
- Most common elderly testicular tumor
a. Metastatic disease
b. Spermatocytic seminoma
c. Lymphoma
d. Germ cell tumour
(*AJL added some… mwahahahaha)
- Most common elderly testicular tumor
c. Lymphoma
- Most common elderly germ cell testicular tumor
a. Spermatocytic seminoma
b. Mixed GCT
c. Pure Seminoma
d. Lymphoma
e. Sertoli cell
*AJL added some to make it better
- Most common eldertly germ cell testicular tumor
a. Spermatocytic seminoma yes
- Wilms least correct
a. Bilateral almost always germ line
b. Unilateral is 50% genetic
c. Genetic wilms have nephrogenic rests
b. Unilateral is 50% genetic 10%
21. Wilms least correct
a. Bilateral almost always germ line
b. Unilateral is 50% genetic 10%
c. Genetic wilms have nephrogenic rests
- Breast least likely in post menopausal
a. IDC
b. LCIS
c. Fibroadenoma
d. Phylloides
e. Papillary
c. Fibroadenoma young
22. Breast least likely in post menopausal
a. IDC
b. LCIS
c. Fibroadenoma young
d. Phylloides
e. Papillary
- Antibodies to GBM
a. Goodpastures
b. PAN
c. Wegners
d. MPA
a. Goodpastures true
28. Antibodies to GBM
a. Goodpastures true
b. PAN
c. Wegners
d. MPA
- Myeloma false
a. IgA
b. IgG
c. Serum light chains
d. BJP
a. IgA less common, maybe this answer or the other not recalled one
29. Myeloma false
a. IgA less common (20%), maybe this answer or the other not recalled one
b. IgG -most common 60%
c. Serum light chains -yes
d. BJP -yes
- Diabetes microangiopathy false
a. Glomerulosclerosis
b. Macula edema
c. Peripheral neuropathy
d. Autonomic neuropathy
- Diabetes microangiopathy false
a. Glomerulosclerosis -yes
b. Macula edema -yes
c. Peripheral neuropathy -yes
d. Autonomic neuropathy -not sure
- DCIS
a. Prognosis depends on histological microarchitecture
b. High grade worse prognosis
b. High grade worse prognosis - correct grading based on comedonecrosis and pleomorphism
27. DCIS
a. Prognosis depends on histological microarchitecture - wrong but some what true if comedonecrosis is included, but I think they mean appearance of papillary, micropapillary, cribiform etc.
b. High grade worse prognosis - correct grading based on comedonecrosis and pleomorphism