[PATH] Bones, Joints and Soft Tissue (Part 1 BONE) [Martin] Flashcards
This image depicts what type of process?

Endochondral ossification
(in a calcaneus)
Root word association:
Osteoporosis =
Osteomalacia =
Osteopetrosis =
Osteogenesis imperfecta =
Osteitis deformans =
Osteodystrophy =
Osteoporosis = Porous; thinned out bone
Osteomalacia = Weakened, soft bone
Osteopetrosis = Peter=rock, stone bone
Osteogenesis imperfecta = Imperfect origin of bone
Osteitis deformans = Deforming bone-itis
Osteodystrophy = Difficult/bad growing bone
What are the (2) components of bone matrix?
Osteoid
Mineral component
Hardness of bones is due to?
Hydroxyapatite
What are the components of osteoid?
Type I collagen with small amounts of glycosaminoglycans and other proteins
What is the protein found in osteoid?
Produced by what?
Function?
How can you utilize osteopontin levels?
Osteopontin (aka osteocalcin)
- produced by osteoblasts
- function: contributes to the regulation of bone formation, mineralization, and calcium homeostasis
- utilization: serum osteopontin levels are used as a sensitive and specific marker of osteoblast activity
What are the (2) histologic forms of bone?
Woven
Lamellar
Characteristics of woven bone?
- Disorganized
- Haphazard arrangement of collagen= less structural integrity
- Produced rapidly ; fetal development and fracture repair
- Abnormal in adults, but not specific for any bone disease

Characteristics of lamellar bone?
Slow production
Parallel collagen
Strong

Function of osteoblasts
Synthesize, transport and assemble matrix
*Regulates mineralization
Function of osteocytes?
-Inactive osteoblasts (inactive osteoblasts can be recognized by a decrease in cytoplasmic volume)
- Control calcium and phosphate levels
- detect mechanical forces and translate them into biological activity in a process known as mechanotransduction
How are osteocytes interconnected?
by an intricate network of dendritic cytoplasmic processes through tunnels (canaliculi)
What are osteoclasts?
Function?
Multinucleated macrophages derived from circulating monocytes
Bone resorption
What is a resorption pit?
When surface integrin proteins allow osteoclasts to attach to the matrix and create a sealed extracellular trench (a resorption pit)
-Secretion of acid and neutral proteases, predominantly matrix metalloproteases (MMPs), into the pit results in dissolution of inorganic and organic components of bone
What type of bone is associated with:
Endochondral ossification?
Intramembranous ossification?
Endochondral ossification = Long bones
Intramembranous ossification = Flat bones
What is the name for the cartilage mold that bones develop from during endochondral ossification?
anlagen
A central medullary canal within the anlagen is created by what in the process of endochondral ossification?
chondroblasts
In the process of endochondral ossification, where do osteoblasts begin to deposit the cortex?
beneath the periosteum of the diaphysis (midshaft)
-this forms a primary center of ossification resulting in radial growth
During endochondral ossification, where is new bone deposited?
- new bone is deposited at the bottom of growth plates (epiphyses)
- this leads to longitudinal growth (secondary centers of ossification)
What is the general process of intramembranous ossification? What type of growth is involved in this process?
- mesenchyme is directly ossified by osteoblasts, there is no cartilage anlagen
- Appositional growth: direct deposit of new bone on pre-existing surface
What are the different zones seen in an active growth plate with ongoing endochondral ossification?
reserve zone, proliferation, hypertrophy, mineralization, and primary spongiosa
Where does remodeling of bone take place? What does it consist of? What is it regulated by?
- within the bone (or basic) multicellular unit (BMU)
- consists of a unit of coupled osteoblast and osteoclast activity on the bone surface
- regulated by cell-cell interactions and cytokines
When is peak bone mass achieved?
Early adulthood after cessation of skeletal growth
At what point is bone resorption > formation?
-fourth decade











