path blood vessels - formatted Flashcards

1
Q
  1. 72.APRIL02 You are asked for advice on screening for cerebral berry aneurysms. Which of the following conditions has THE LEAST risk of aneurysm of the circle of Willis?
  2. Neurofibromatosis type 1
  3. Marfan Syndrome
  4. Coarctation of the aorta
  5. Adult/ [Autosomal dominant] Polycystic Kidney Disease
  6. Systemic Lupus Erythematosis
A
  1. Systemic Lupus Erythematosis - F -
Known associations include: 
ADPCKD, 
Ehlers-Danlos type 4, 
NF1, 
Marfans, 
FMD of extracranial arteries, 
coarctation of aorta, 
hypertension (in 54% of patients).  
Most are sporadic.
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2
Q
  1. 68.APRIL02 A 53-year-old female has increasing congestive cardiac failure and normal vessels at coronary angiography. As a child she suffered rheumatic fever. The cardiac valves most likely to be affected are:
  2. Aortic alone
  3. Mitral and aortic
  4. Mitral and pulmonic
  5. Aortic and pulmonic
  6. Tricuspid and mitral
A
  1. Mitral and aortic - T - Rheumatic heart disease is overwhelmingly the most frequent cause of mitral stenosis (99% of cases). In patients with rheumatic heart disease, the mitral valve alone is involved in 65 to 70% of the cases, mitral and aortic in about 25%. Similar but generally less severe fibrous thickenings and stenoses can occur in the tricuspid valve
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3
Q
  1. 66.APRIL02 A 12-year-old male dies after a motor vehicle accident. At autopsy, mutiple yellow elongated lesions are seen on the intima of his otherwise normal abdominal aorta. Which of the following statements about this entity IS LEAST correct?
  2. Coronary lesions are less common than aortic lesions
  3. They are composed of lipid-filled foam cells and T lymphocytes
  4. More common in Western children than in Africa
  5. Can be seen in children less than 1 year of age
  6. Not all progress to fibrous atheromatous plaques
A
  1. More common in Western children than in Africa - F - Fatty streaks occur in all children older than 10y regardless of geography, race, sex or environment.
  2. 66.APRIL02 + APRIL 2004 A 12-year-old male dies after a motor vehicle accident. At autopsy, multiple yellow elongated lesions are seen on the intima of his otherwise normal abdominal aorta. Which of the following statements about this entity IS LEAST correct? (JS)
  3. Coronary lesions are less common than aortic lesions - T - Coronary fatty streaks are less common than aortic, beginning to form in adolescence, and they occur at the same anatomic sites that are later prone to develop plaques
  4. They are composed of lipid-filled foam cells and T lymphocytes - T - composed of lipid-filled foam cells with T lymphocytes and extracellular lipid present in smaller amounts than in plaques
  5. More common in Western children than in Africa - F - Fatty streaks occur in all children older than 10y regardless of geography, race, sex or environment.
  6. Can be seen in children less than 1 year of age - T
  7. Not all progress to fibrous atheromatous plaques T - although fatty streaks may be precursors of plaques, not all fatty streaks are destined to become fibrous plaques or more advanced lesions)
  • Fatty streaks are not significantly raised and thus do not cause any disturbance in blood flow.
  • They may be precursors, however, of the more ominous atheromatous plaques.
  • The streaks begin as multiple yellow; flat spots ( fatty dots) less than 1 mm in diameter that coalesce into elongated streaks; 1 cm long or longer.
  • Fatty streaks are composed of lipid-filled foam cells with T lymphocytes and extracellular lipid present in smaller amounts than in plaques.
  • Fatty streaks appear in the aortas of some children younger than 1 year of age and all children older than 10 years, regardless of geography, race, sex, or environment.
  • Coronary fatty streaks are less common than aortic but begin to form in adolescence, and they occur at the same anatomic sites that are later prone to develop plaques.
  • They subsequently decrease in number as atherosclerotic plaques become more prevalent.
  • The relationship of fatty streaks to atherosclerotic plaques is complex. o Fatty streaks are related to the known risk factors of atherosclerosis in adults (especially serum lipoprotein cholesterol concentrations and smoking), and some experimental evidence supports the concept of the evolution of fatty streaks into plaques.
  • Fatty streaks, however, often occur in areas of the vasculature that are not particularly susceptible to developing atheromas later in life.
  • Moreover, they frequently affect individuals in geographic locales and populations in which atherosclerotic plaque is uncommon.
  • Thus, although fatty streaks may be precursors of plaques, not all fatty streaks are destined to become fibrous plaques or more advanced lesions.
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4
Q

Atherosclerosis

1) define
2) modiafiable factors
3) non-modifiable factors
4) describe fatty streaks
5) list the step of atherosclerosis

A

1)
- chronic vascular disease
- accumulation of cholesterol within the wall of the vessel causing progressive narrowing

2)
- smoking, drinking
- obesity
- DM
- hypertension

3) - age- sex- familial - genetics

4)
a) Fatty dots in intima
b) coalesce to call fatty streaks- foamy cells and cholesterol, less compared to an atheroma
- can occur in children
- aorta 1st, then all children have it by 10 years
- coronary artery in adolescent
- not all progress onto atheroma

5)
A) LDL move into intima- by vascular damage (smoking, hypertension)
b) oxidised LDL release cytokines- release MCP (monocyte attractant protein)
-> attract SM and monocyte- release M-CSF (macrophage stimulating factors)
-> change monocyte to macrophage
-> macrophage injest LDL
-> becomes foamy macrophage

Foamy cell-> cause SM proliferation

  • > enlarging atheroma develop
  • thin fibrous capsule
  • eventually ruptures then clots with platelets and thrombin
  • repeated rupture narrows lumen
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5
Q
  1. 62.APRIL02 Which of the following IS NOT correct regarding polyarteritis nodosa?
  2. There is a transmural necrotising vasculitis of small to medium size arteries
  3. There is associated glomerulonephritis
  4. There is sparing of the pulmonary circulation
  5. It is associated with Hepatitis B antigen positivity in over 20% of cases
  6. Remission or cure is achieved in 90% with steroid and cycle
A
  1. There is associated glomerulonephritis - F - Renal involvement is one of the prominent manifestations, BUT because there is no small vessel involvement, glomerulonephritis is not present.
  2. 62.APRIL02 Which of the following IS NOT a correct regarding polyarteritis nodosa? (JS)
  3. There is a transmural necrotising vasculitis of small to medium size arteries - T - Systemic vasculitis manifested by transmural necrotizing inflammation of small or medium-sized muscular arteries, typically renal and visceral, sparing pulmonary circulation. The common manifestations are malaise, fever,weight loss, hypertension, abdominal pain, malaena, muscle aches, peripheral neuritis. Little association with ANCA. Angiography shows aneurysms or occlusions of the main visceral arteries in 50% of cases. (Robbins)
  4. There is associated glomerulonephritis - F - Renal involvement is one of the prominent manifestations, BUT because there is no small vessel involvement, glomerulonephritis is not present.
  5. There is sparing of the pulmonary circulation - T
  6. It is associated with Hepatitis B antigen positivity in over 20% of cases - T - 30% patients have hepatitis B antigen in serum
  7. Remission or cure is achieved in 90% with steroid and cyclophosphamide - T - Disease is fatal if untreated but therapy is very effective.

SOh: PAN- Systemic vasculitis causing necrotizing inflammation of small and medium-sized vessels, resulting in microaneurysms, occlusions, and strictures. Acute renal failure, HTN, perirenal hematoma. GN not seen in PAN.
c.f. Microscopic polyangiitis: small arterioles and capillaries. Necrotizing GN (90%) and pulmonary capillaritis. No microaneurysms.

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6
Q

63.APRIL02 Which of the following would be an UNEXPECTED finding following coronary angioplasty?

  1. Luminal expansion
  2. Plaque rupture
  3. Thickened intact intima
  4. Medial dissection
  5. Proliferative restenosis in 30-50% of patients at 6 months
A
  1. Thickened intact intima - F - The split encompasses the intima and media
  2. 63.APRIL02 Which of the following would be an UNEXPECTED finding following coronary angioplasty? (JS)
  3. Luminal expansion - T - The key elements of luminal expansion in angioplasty are plaque rupture, medial dissection and stretching of the media of the dissected segment.
  4. Plaque rupture - T
  5. Thickened intact intima - F - The split encompasses the intima and media
  6. Medial dissection - T
  7. Proliferative restenosis in 30-50% of patients at 6 months - T -

The long-term success of angioplasty is limited by the development of proliferative restenosis that occurs in approximately 30 to 50% of patients within the first 4 to 6 months after angioplasty
• The process of balloon dilation of an atherosclerotic vessel characteristically causes plaque fracture, often with accompanying localized hemorrhagic dissection of the adjacent arterial wall.
• The plaque splits at its weakest point, which is not necessarily the area most severely obstructed.
• The key elements of luminal expansion in angioplasty are plaque rupture, medial dissection, and stretching of the media of the dissected segment, leading to local flow abnormalities and generation of new, potentially thrombogenic blood-contacting surfaces.
• Thus, an atherosclerotic plaque after angioplasty is unstable, having many features of the disrupted plaque associated with the acute coronary syndromes and other complications of atherosclerosis
• Uncommonly, abrupt reclosure follows the angioplasty. o This reclosure usually occurs as a result of compression of the lumen by an extensive circumferential or longitudinal dissection or by thrombosis.o Nevertheless, most patients improve symptomatically after angioplasty, thereby avoiding the need for aortocoronary bypass graft surgery at that time.
• The long-term success of angioplasty is limited by the development of proliferative restenosis that occurs in approximately 30 to 50% of patients within the first 4 to 6 months after angioplasty

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7
Q
  1. 64.APRIL02 A 33-year-old woman has sudden onset of blindness in her left eye. The multislice CT angiogram shows marked diffuse narrowing of her brachiocephalic, subclavian and common carotid arteries. There is also involvement both of her external and internal carotid arteries. This distribution is most suggestive of:
  2. Takayasu arteritis
  3. Atherosclerosis associated with familial
    hypercholesterolaemia
  4. Giant cell arteritis
  5. Polyarteritis nodosa
  6. Fibromuscular hyperplasia
A
  1. Takayasu arteritis - T - clinical syndrome characterized principally by ocular disturbances and marked weakening of the pulses in the upper extremities (pulseless disease), related to fibrous thickening of the aortic arch with narrowing or virtual obliteration of the origins or more distal portions of the great vessels arising in the arch. It has been reported in most areas of the world, including the United States. The illness is seen predominantly in women younger than 40 years old6.
  2. APRIL02 A 33-year-old woman has sudden onset of blindness in her left eye. The multislice CT angiogram shows marked diffuse narrowing of her brachiocephalic, subclavian and common carotid arteries. There is also involvement both of her external and internal carotid arteries. This distribution is most suggestive of: (JS)
  3. Takayasu arteritis - T - clinical syndrome characterized principally by ocular disturbances and marked weakening of the pulses in the upper extremities (pulseless disease), related to fibrous thickening of the aortic arch with narrowing or virtual obliteration of the origins or more distal portions of the great vessels arising in the arch. It has been reported in most areas of the world, including the United States. The illness is seen predominantly in women younger than 40 years old
  4. Atherosclerosis associated with familial hypercholesterolaemia - F - causes premature atherosclerosis in the same distribution as non-familial cases (ie abdominal aorta, ostia of major branches, coronary arteries, popliteal, descending thoracic, ICA and circle of Willis)
  5. Giant cell arteritis - F - most common of the vasculitides, is an acute and chronic, often granulomatous, inflammation of medium-sized and small arteries. It affects principally the arteries in the head– especially the temporal arteries– but also the vertebral and ophthalmic arteries. The latter may lead to blindness. In other expressions of this disorder, lesions have been found in arteries throughout the body, and in some cases the aortic arch has been involved to produce so-called giant cell aortitis. The disease is most common in older individuals and rare before the age of 50
  6. Polyarteritis nodosa - F - necrotising inflammation of medium sized or small arteries without GN or vasculitis within arterioles, capillaries or venules.
  7. Fibromuscular hyperplasia - F - proliferation of the muscular and fibrous elements in middle and large sized arteries of unknown aetiology. Affects renal arteries, ICA or vertebral, iliac, visceral.
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8
Q
  1. 10.02.11 Which of the following conditions IS NOT a cause (or association) of dissection ?
  2. Hypertension
  3. Arteriosclerosis
  4. Pregnancy
  5. Marfan’s syndrome
  6. Cystic medial degeneration
A
  1. Arteriosclerosis - F - medial scarring obstructs advancement of a dissecting aneurysm.
  2. 02.11 Which of the following conditions IS NOT a cause (or association) of dissection ? Rob 341 (JS)
  3. Hypertension - T - more than 90% of cases
  4. Arteriosclerosis - F - medial scarring obstructs advancement of a dissecting aneurysm
  5. Pregnancy - T - for unknown causes occurs shortly after pregnancy
  6. Marfan’s syndrome - T - and other connective tissue disorders (Ehlers-Danlos syndrome, Turner’s) are associated with Cystsic Medial Degeneration
  7. Cystic medial degeneration - T - CMD consists of elastic fragmentation and separation of the elastic and fibromuscular elements of the tunica media. This is the most frequently preexisting histologically detectable lesion in dissection but it can be found incidentally at autopsy in patients free from dissection.
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9
Q
  1. 10.03.18 Patient A has dissection involving ascending aorta, Patient B has dissection involving ascending aorta, arch and descending aorta
  2. Both have type A
  3. Both have type B
  4. Patient A has type A and patient B has type B
  5. Patient A has DeBakey III and patient B has type B
  6. Patient A has DeBakey I and patient B has DeBakey III
A
  1. Both have type A
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10
Q
  1. 10.02.21 Kawasaki disease – which of the following is FALSE?
  2. Mostly occur in children younger than 2 years of age
  3. Is self-limited disorder with less than 1% death rate
  4. > 20% develop CVS sequale
  5. characterised by recurrent attacks
A
  1. characterised by recurrent attacks - F - Kawasaki syndrome is an arteritis involving large, medium and small arteries (often coronaries), associated with the mucocutaneous lymph node syndrome (fever, conjunctival and oral erythema and erosion, oedema of hands and feet, rash and cervical lymph nodes), usually in young children and infants. It is self limited.
  2. 10.02.21 Kawasaki disease – which of the following is FALSE? Rob p350 (JS)
  3. Mostly occur in children younger than 2 years of age - T - occurs in young children and infants with 80% younger than 4 years of age
  4. Is self-limited disorder with less than 1% death rate - T - acute fatalities occur in 1% of patients owing to coronary arteritis with superimposed thrombosis or ruptured coronary artery aneurysm
  5. > 20% develop CVS sequale - T - approximately 20% develop CVS sequelae including vasculitis of coronary arteries, ectasia, aneurysm formation with rupture, thrombosis, MI or sudden death
  6. characterised by recurrent attacks - F - Kawasaki syndrome is an arteritis involving large, medium and small arteries (often coronaries), associated with the mucocutaneous lymph node syndrome (fever, conjunctival and oral erythema and erosion, oedema of hands and feet, rash and cervical lymph nodes), usually in young children and infants. It is self limited.

KAWASAKI SYNDROME (MUCOCUTANEOUS LYMPH NODE SYNDROME)
• arteritis involving large, medium-sized, and small arteries (often the coronary arteries)• associated with the mucocutaneous lymph node syndrome, usually in young children and infants (80% younger than 4 years old).
• The acute illness is manifested by fever, conjunctival and oral erythema and erosion, edema of the hands and feet, erythema of the palms and soles, a skin rash often with desquamation, and enlargement of cervical lymph nodes
• It is usually self-limited
• Epidemic in Japan, the disease has also been reported in Hawaii and increasingly in the United States
• Approximately 20% of patients develop cardiovascular sequelae, with a range of severity from asymptomatic vasculitis of the coronary arteries, coronary artery ectasia, or aneurysm formation to giant coronary artery aneurysms (7 to 8 mm) with rupture or thrombosis, myocardial infarction, or sudden death.
• Kawasaki syndrome is the leading cause of acquired heart disease in children in the United States
• Acute fatalities occur in approximately 1% of patients owing to coronary arteritis with superimposed thrombosis or ruptured coronary artery aneurysm.
• Pathologic changes outside the cardiovascular system are rarely significant.
• Although the vasculitis resembles that of polyarteritis nodosa, with necrosis and pronounced inflammation affecting the entire thickness of the vessel wall, fibrinoid necrosis is usually less prominent in Kawasaki syndrome

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11
Q
  1. 10.02.31 What is the COMMONEST LESION/ SYSTEM involved in Wegener’s granulomatosis?
  2. Lungs
  3. Nasal cavity
  4. Kidneys
  5. Skin
  6. Paranasal sinus
A
  1. Lungs - T - persistent pneumonitis with bilateral nodular and cavitary infiltrates (95%)
  2. 10.02.31 What is the COMMONEST LESION/ SYSTEM involved in Wegener’s granulomatosis? Rob p351 (JS)
  3. Lungs - T - persistent pneumonitis with bilateral nodular and cavitary infiltrates (95%)
  4. Nasal cavity - F - mucosal ulceration of the nasopharynx (75%)
  5. Kidneys - F - evidence of renal disease (80%).
  6. Skin - F - Other features include skin rashes, muscle pain, articular involvement, mono or polyneuritis, fever
  7. Paranasal sinus - F - chronic sinusitis (90%)
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12
Q
  1. 10.02.73 Features of cystic lymphangioma do NOT include ?
  2. axillary location
  3. child 18 months old
  4. large cystic spaces
  5. benign lesion
  6. encapsulated
A

encapsulated - F - The margins of the tumor are not discrete, and these lesions are not encapsulated. Their removal can therefore be difficult.

  1. 10.02.73 Features of cystic lymphangioma do NOT include ? Rob p357
  2. axillary location - T - Almost invariably occur in children in the neck or axilla (rarely retroperitoneal)
  3. child 18 months old - T - Lymphangiomas are congenital malformations with 50-65% present at birth and 80-90% evident by 2 years
  4. large cystic spaces - T - made up of massively dilated cystic spaces lined by endothelial cells and separated by scant connective tissue stroma
    benign lesion - T
    encapsulated - F - The margins of the tumor are not discrete, and these lesions are not encapsulated. Their removal can therefore be difficult.
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13
Q
  1. Sep03.03 Which finding makes it less likely to be Wegener’s granulomatosis?
  2. lack of sinus involvement.
  3. Negative for cANCA
  4. Lack of renal involvement
A
  1. Negative for cANCA - T - cANCA is positive in 90% of patients with active generalised disease and has a specificity of 99% (according to Dahnert).
    * Robbins says positive in up to 95%
  2. Sep03.03 Which finding makes it less likely to be Wegener’s granulomatosis? (JS)
  3. lack of sinus involvement - F - 90% show chronic sinusitis
  4. Negative for cANCA - T - cANCA is positive in 90% of patients with active generalised disease and has a specificity of 99% (according to Dahnert)
  5. Lack of renal involvement - F - 80% show evidence of renal disease
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14
Q
  1. Sep03.47 Aortic dissection.
  2. Can occur without an intimal flap
  3. Longitudinal
  4. 30-50cm long
  5. aortic valve prevents involvement coronary arteries
A
  1. Can occur without an intimal flap - T - There is usually (but not always) an intimal tear that extends into but not through the media of the ascending aorta (Robbins). According to Primer, intimal flap is detectable in 85-90%.
  2. Sep03.47 + APRIL 2004 Aortic dissection. (JS)
  3. Can occur without an intimal flap - T - There is usually (but not always) an intimal tear that extends into but not through the media of the ascending aorta (Robbins). According to Primer, intimal flap is detectable in 85-90%.
  4. Longitudinal - F - tears are usually transverse or oblique, 1-5cm in length with sharp jagged edges
  5. 30-50cm long - F - I presume they mean the length of the tear (1-5cm) or the length of the dissection which is variable
  6. Aortic valve prevents involvement coronary arteries - F - occlusion of coronary aa in 8%
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15
Q
  1. PATH2004 Which of the following statements with regards to fatty plaques is LEAST CORRECT?
  2. frequently affect individuals in geographic locales and populations in which atherosclerotic plaque is uncommon.
  3. ?% of kids that have them
  4. ?site
  5. bld vess and heart pg 503 blue box know well
A
  1. frequently affect individuals in geographic locales and populations in which atherosclerotic plaque is uncommon. (T)
  2. PATH2004 Which of the following statements with regards to fatty plaques is LEAST CORRECT? (–)
  3. frequently affect individuals in geographic locales and populations in which atherosclerotic plaque is uncommon. (T)
  4. ?% of kids that have them (some younger than 1, all older than 10 yoa)
  5. ?site (aorta more common than coronary arteries)
  6. bld vess and heart pg 503 blue box know well
    • Fatty streaks are not significantly raised and thus do not cause any disturbance in blood flow.
    • They may be precursors, however, of the more ominous atheromatous plaques.
    • The streaks begin as multiple yellow; flat spots ( fatty dots) less than 1 mm in diameter that coalesce into elongated streaks; 1 cm long or longer.
    • Fatty streaks are composed of lipid-filled foam cells with T lymphocytes and extracellular lipid present in smaller amounts than in plaques.
    • Fatty streaks appear in the aortas of some children younger than 1 year of age and all children older than 10 years, regardless of geography, race, sex, or environment.
    • Coronary fatty streaks are less common than aortic but begin to form in adolescence, and they occur at the same anatomic sites that are later prone to develop plaques.
    • They subsequently decrease in number as atherosclerotic plaques become more prevalent.
    • The relationship of fatty streaks to atherosclerotic plaques is complex.
    o Fatty streaks are related to the known risk factors of atherosclerosis in adults (especially serum lipoprotein cholesterol concentrations and smoking), and some experimental evidence supports the concept of the evolution of fatty streaks into plaques.
    • Fatty streaks, however, often occur in areas of the vasculature that are not particularly susceptible to developing atheromas later in life.
    • Moreover, they frequently affect individuals in geographic locales and populations in which atherosclerotic plaque is uncommon.
    Thus, although fatty streaks may be precursors of plaques, not all fatty streaks are destined to become fibrous plaques or more advanced lesions.
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16
Q
  1. PATH2004 Regarding polyarteritis nodosa. Which of the following is/are false:
  2. The kidneys are most commonly involved in autopsy
  3. Aneurysms are seen at angiography in 50%
  4. 70% are seropositive for Hepatitis B surface antigen
  5. Churg Strauss syndrome frequently involves pulmonary and splenic vessels
  6. Serum anti-neutrophil antibody titres correlate with disease activity
A
  1. 70% are seropositive for Hepatitis B surface antigen - F - 30% have hepatitis B antigenaemia, and HBsAg-HBsAb immune complexes can be demonstrated in the lesions.
  2. PATH2004 Regarding polyarteritis nodosa. Which of the following is false: (GC)
  3. The kidneys are most commonly involved in autopsy - T - vessels of the kidneys, heart, liver, and GIT are involved in descending order.
  4. Aneurysms are seen at angiography in 50% - T - multiple small intrarenal microaneurysms typically at branchpoints in 50-60% - hallmark feature. Lesions usually involve only part of the vessel circumference; the inflammatory process weakens the arterial wall and can lead to aneurysms or even rupture.
  5. 70% are seropositive for Hepatitis B surface antigen - F - 30% have hepatitis B antigenaemia, and HBsAg-HBsAb immune complexes can be demonstrated in the lesions.
  6. Churg Strauss syndrome frequently involves pulmonary and splenic vessels - T - aka allergic granulomatosis and angiitis; vascular lesions can resemble PAN and microscopic polyangiitis, but in the lung, heart, spleen, peripheral nerves and skin there are also intra- and extravascular granulomas. PAN spares the pulmonary circulation.
  7. Serum anti-neutrophil antibody titres correlate with disease activity - T - A positive ANCA argues against PAN and in favor of one of the ANCA-associated vasculitides (UpToDate), however Adelaide path notes state that p-ANCA is often present in serum and correlates with disease activity. eMed: ANCA are often present in the serum of patients with PAN; in such patients ANCA levels often correlate with disease activity. However ANCA can be present in patients with other vasculitides (Churg-Strausss, Wegener, microscopic polyangitis) (GC / TW)

(–) No correlation with ANCA, Robbins doesn’t mention ANA, and I am pretty sure this question is specific to wegners in which it is correlated with disease activity. So both c and e are incorrect. I think c is the least controversial false answer, but there are so many new classifications of PAN that the waters get very muddy. Perhaps it is a bad recall.
*LW: agree with above logic - Robbins states NO association with ANCA, so hence 5 is also false if referring to poly arteritis nodosa, but i would have incorrect recall and Hep B is the correct recall.

17
Q
  1. PATH2004 Which of the following conditions IS TRUE with regards to hypertension?
  2. 5-10% of dissections have no obvious intimal tear - this was the true answer
A
  1. PATH2004 Which of the following conditions IS TRUE with regards to hypertension?
  2. 5-10% of dissections have no obvious intimal tear - this was the true answer
18
Q
  1. PATH2004 Leiomyoma is least common
  2. Heart/Myocardium
  3. Blood vessels/vascular smooth muscle
  4. Oesophagus
  5. Stomach
  6. Uterus
A
  1. Heart/Myocardium - T - extremely rare (if at all existent!); there are a case reports of benign metastasizing leiomyomas to heart (most common site is lung); occurring years after fibroid removal.
    Common benign cardiac tumors are myxoma (30% of all primary cardiac tumors), papillary fibroelastoma (8%), rhabdomyoma, fibroma, hemangioma, lipomatous hypertrophy, AV nodal tumors, other (5% or less each). In children, common tumors are rhabdomyoma, fibroma and teratoma.
  2. PATH2004 Leiomyoma is least common: (GC)
  3. Heart/Myocardium - T - extremely rare (if at all existent!); there are a case reports of benign metastasizing leiomyomas to heart (most common site is lung); occurring years after fibroid removal.
    Common benign cardiac tumors are myxoma (30% of all primary cardiac tumors), papillary fibroelastoma (8%), rhabdomyoma, fibroma, hemangioma, lipomatous hypertrophy, AV nodal tumors, other (5% or less each). In children, common tumors are rhabdomyoma, fibroma and teratoma.
  4. Blood vessels/vascular smooth muscle - F - aka angioleiomyoma, relatively common, painful tumours - usually females 30-60yo., often in soft tissues of lower limbs; tumours in males more common in UL and H&N.
  5. Oesophagus - F - most common benign submucosal tumour of oesophagus; 50% of all benign oesoph tumours. Frequently lower and mid 1/3.
  6. Stomach - F - second most common benign gastric tumour (after polyps); most common of calcified benign tumours; submucosal in 60% (accounts for 90% of submucosal tumours, ulcerated in 50%).
  7. Uterus - F - most common gynae neoplasm; commonest cause for uterine enlargement after pregnancy. Incidence 20-25% of whites, 50% of blacks. Intramural, subserosal, submucosal.
    [Path outlines; Dahnert]
19
Q
  1. PATH2004 Wegener’s granulomatosis is characterised by all of the following except
  2. generalised vasculitis
  3. GN
  4. Granulomatosis of the upper and lower respiratory tract
  5. ANA +ve
  6. ANCA +ve
A
  1. ANA +ve - F
  2. PATH2004 Wegener’s granulomatosis is characterised by all of the following except (JS)
  3. generalised vasculitis - T - A necrotising vasculitis characterised by (1) acute necrotising granulomas of the upper and lower respiratory tracts, (2) focal necrotizing or granulomatous vasculitis affecting small to medium sized vessels and (3) renal disease in the form of focal or necrotising, often crescentic glomerulitis.
  4. GN - T
  5. Granulomatosis of the upper and lower respiratory tract - T
  6. ANA +ve - F
  7. ANCA +ve - T - c-ANCA is present in 90% of patients with active disease
20
Q
  1. PATH2004 Aortic dissection
  2. Associated with Marfan’s
  3. Stanford
  4. Bicuspid valve
  5. Intimal flap visible in 90%
  6. DeBakey type 2 is the most common
A
  1. DeBakey type 2 is the most common - F - DeBakey Type 1 involves ascending and descending aorta (50%), Type 2 involves ascending aorta only (10%), Type 3 involves descending aorta (40%)
  2. PATH2004 Aortic dissection (JS)
  3. Associated with Marfan’s T - Causes include hypertension, Marfans, Ehlers-Danlos, Aortic coarctation and bicuspid or unicuspid valve
  4. Stanford classification system - T - Stanford classification - Type A involves ascending aorta, Type B involves descending aorta
  5. Bicuspid valve T - Causes include hypertension, Marfans, Ehlers-Danlos, Aortic coarctation and bicuspid or unicuspid valve
  6. Intimal flap visible in 90% - T - Intimal flap is usually present with haematoma spreading between the middle and outer 1/3 of the media.
  7. DeBakey type 2 is the most common - F - DeBakey Type 1 involves ascending and descending aorta (50%), Type 2 involves ascending aorta only (10%), Type 3 involves descending aorta (40%)
21
Q
  1. Concerning risk factors for atherosclerosis, which of the following is LEAST CORRECT:
  2. Most striking association is with elevated serum levels of LDL
  3. After 45, hypertension is a greater risk factor than hypercholesterolaemia
  4. Smoking increases incidence of sudden death among victims of heart attacks
  5. There is a two fold increase in the incidence of MI in diabetics vs non-diabetics
  6. Systolic hypertension is more important than diastolic hypertension
A

*LW: Robbins and article in journal HTN state: “The risk of cardiovascular disease increases progressively and continuously with increases in SBP and DBP independent of other risk factors; in particular, increased SBP levels are more important than increased DBP”, with Big Robbins stating “ SBP is more important than DBP as a determinent of cardiovascular risk, except in young patients”.
Thus assuming this correlates as risk factor for atherosclerosis, option 5 could be considered correct.
Therefore, i wonder if incorrect recall, as all are correct.

Previous answer:
5. Systolic hypertension is more important than diastolic hypertension - F - Both systolic and diastolic levels are important in increasing risk

  1. Concerning risk factors for atherosclerosis, which of the following is LEAST CORRECT: (JS)
  2. Most striking association is with elevated serum levels of LDL - T
  3. After 45, hypertension is a greater risk factor than hypercholesterolaemia - T:
    * LW: graph of risk factors in Robbins shows a greater increase in risk for increased BP than cholesterol.
  4. Smoking increases incidence of sudden death among victims of heart attacks - ?
    *LW: Couldn’t find this is Robbins. Not stated in Robbins, but generally reported.
    Closest i can find in Robbins “ Smoking increases death rate from IHD by up to 200%”
  5. There is a two fold increase in the incidence of MI in diabetics vs non-diabetics - *LW: T word for word from Robbins.
  6. Systolic hypertension is more important than diastolic hypertension - F - Both systolic and diastolic levels are important in increasing risk *LW disagrees as above.
22
Q
  1. PATH2004 Regarding fatty streaks, which of the following is LEAST CORRECT:
  2. Extracellular lipid is present in smaller amounts than in atheromatous plaques
  3. Streaks decrease in number as atheromatous plaques begin to predominate
  4. 10% of the aortic intimal surface is involved by the third decade of life
  5. Development is independent of racial origin and geography
  6. Distribution of plaques differs from the distribution of fatty streaks.
A
  1. 10% of the aortic intimal surface is involved by the third decade of life - F - The area of fatty streak develops by 10y and comprises 4-5% of the intimal surface
  2. PATH2004 Regarding fatty streaks, which of the following is LEAST CORRECT: (JS)
  3. Extracellular lipid is present in smaller amounts than in atheromatous plaques - T - composed of lipd-filled foam cells with T lymphocytes and extracellular lipid, present in smaller amounts than in plaques
  4. Streaks decrease in number as atheromatous plaques begin to predominate - T
  5. 10% of the aortic intimal surface is involved by the third decade of life - F - The area of fatty streak develops by 10y and comprises 4-5% of the intimal surface
  6. Development is independent of racial origin and geography - T - Occur in all children over the age of 10y regardless of geography, race, sex or environment.
  7. Distribution of plaques differs from the distribution of fatty streaks. - T - According to Robbins, fatty streaks often occur in areas of vasculature that are not particularly susceptible to developing atheromas later in life.
    (SOh: “For coronary fatty streaks- begin to form in adolescence at same anatomic sites that later tend to develop plaques” pg 340 robbins)
23
Q
  1. PATH2004 Regarding aortic dissection. Which of the following is the MOST CORRECT:
  2. 5-10% do not have an obvious intimal tear
  3. Hypertension is an antecedent in 50% of cases
  4. Haemorrhage typically occurs between the inner and middle thirds of the media
  5. Elastic fragmentation of the media is rare at autopsy in patients free of dissection
  6. Intimal tear is found in the proximal descending thoracic aorta in 90% of cases
A
  1. 5-10% do not have an obvious intimal tear T - There is usually (but not always) an intimal tear that extends into but not through the media of the ascending aorta (Robbins). According to Primer, intimal flap is detectable in 85-90%.
  2. PATH2004 Regarding aortic dissection. Which of the following is the MOST CORRECT: (JS)
  3. 5-10% do not have an obvious intimal tear T - There is usually (but not always) an intimal tear that extends into but not through the media of the ascending aorta (Robbins). According to Primer, intimal flap is detectable in 85-90%.
  4. Hypertension is an antecedent in 50% of cases F – more than 90% occur in patients with hypertension
  5. Haemorrhage typically occurs between the inner and middle thirds of the media F – haematoma spreads between the middle and outer 1/3 of the media
  6. Elastic fragmentation of the media is rare at autopsy in patients free of dissection - F - cystic medial degeneration (fragmentation and separation of the elastic and fibromuscular elements of the tunica media) is frequently found incidentally at autopsy in patients free of dissection (Robbins)
  7. Intimal tear is found in the proximal descending thoracic aorta in 90% of cases F - typically involves the ascending aorta
24
Q
  1. PATH2004 Regarding aortic coarctation, which of the following IS NOT a well recognised association:
  2. PDA
  3. Ventriculoseptal defect
  4. Dural AVM
  5. Berry aneurysms of the circle of Willis
  6. Bicuspid valve
A
  1. Dural AVM
  2. PATH2004 Regarding aortic coarctation, which of the following IS NOT a well recognised association: (TW)
  3. PDA – 33%
  4. Ventriculoseptal defect – 15%
  5. Dural AVM
  6. Berry aneurysms of the circle of Willis - associated
  7. Bicuspid aortic valve – assoc with bicuspid aortic valve in 25-50%
*LW:
Robbins associations:
Bicuspid valve 50%
Congenital AS
ASD
VSD
MR
Berry aneurysms.
PDA (infantile presentation)

(Dahnert 6th ed.) Coarctation – 50% associated with
o bicuspid arotic valve (in 25-50%)
o intracardiac malformations – PDA, VSD, AS, AR, ASD, TGV, ostium primum defect, truncus arteriosus, double-outlet RV.
o Non-cardiac malformations. Turner syndrome.
o Cerebral berry aneurysms
o Mycotic aneurysm distal to CoA.