path Flashcards
Bence Jones Proteins
Multiple Myeloma (Ig Light chains in urine) also see *Rouleax formation* of RBC stacking like poker chips
Rosenthal Fibers
Pilocytic Astrocytoma (childhood primary brain tumor) usually cerebellar, GFAP+
Reed Sternberg Cells
Hodgkins Lymphoma (aka “owls eye”) (CD15+ and CD30+)
Stary Sky appearance
Burkitts Lymphoma (8;14)
Homer-Wright Rosettes, small blue cells
Medulloblastoma (childhood cerebellar brain tumor)
perivascular pseudorosettes
Ependymoma (childhood 4th ventricle brain tumor)
Spindle cells in a whorled pattern, psammoma bodies
Meningioma (adult primary brain tumor)
Fried egg appearance
Oligodendroglioma (rare, adult, “chicken wire vasculature)
Leser-Trelat sign
sudden multiple sebhorric keratosis popping up, associated with GI or GU or lymphoid malignacy
MPO+, Auer Rods
AML t(15;17)
TdT+
ALL t(12;21) (not to be confused with trap+)
TRAP +
hairy cell leukemia (not to be confused with tdt+)
spindle shaped fibroblasts
ovarian fibroma (usually part of Meigs syndrome: ovarian fibroma, ascites, pleural effusion)
codman’s angle, sunburst pattern
Osteosarcoma
is: malignant proliferation of osteoblasts
at metaphysis of teens
pt may have defect of the retinoblastoma (Rb) gene which regulates G1–>S phase
soap bubble appearance
giant cell tumor
onion skin appearance of bone
ewings sarcoma t(11;22)
combank: “concentric formation of new bone layers in the periosteum”
orphan annie eye nuclei
papillary carcinoma of the thyroid (most common)
risk factor: childhood irradiation
also has psammoma bodies
Hurthle Cells
Hashimotos (autoimmune hypothyroid) also see germinal centers with lymphocytic infiltrate
painful goiter
subacute (granulomatous) thyroiditis (aka dequervain’s)
the only one with a painful goiter – self-limiting hypothyroid following flu-like illness
Call-Exner bodies
Granulosa cell tumors (call-exner bodies are small follicles filled with eosinophilic secretions)
Schiller Duval bodies
glomerulus-like structures seen in Endodermal sinus tumors (aka yolk sac tumor)
Reinke Crystals
Leydig cell tumor (can occur in men or women, secrete androgen, see hirtuism in women)
signet ring cells
anything thats mucus producing (mucinous cells push nucleus off to the side)
“jelly belly”
psuedomyxoma peritonei
tons of mucus in the peritoneum usually from mucinous tumor of the appendix
likes b/l mets to the ovaries
(Krukenberg tumor - the other mets to the ovaries, usually from diffuse gastric CA (mucinous as well))
smudge cell
CLL
Mallory Bodies
in liver; associated with alcoholic liver disease (probably the same guy who named Mallory-Weiss)
Councilman bodies
in the liver; associated with apoptosis of virus infected hepatocytes
Ferruginous bodies
in lung; associated with asbestos
stain Prussian Blue
basophilic stippling in RBC
lead poisoning (denatures ribonuclease so ribosomes can not be degraded) otherwise, sideroblastic anemia
Kulchitsky cells
small cell lung cancer
palisading nuclei
Basal cell carcinoma
Lisch Nodules
Neurofibromatosis type 1 (von Recklinghausen disease)
these are pigmented iris hamartomas
ringed sideroblasts
sideroblastic anemia (microcytic) these are iron rings in the mitochondria indicate defective heme synthesis dt decreased protoporphyrin bc its trapped in mitochondria
hereditary: D-ala-synthase defect
acquired: alcohol, lead, isoniazid
charcot leyden crystals
asthma/parasitic infection (in sputum or stool if parasite)
wire looping of capillaries under light microscope
diffuse proliferative glomerulonephritis (nephritic)
subEPIthelial immune complexes
post strep glomerulonephritis (nephritic)
