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1
Q

Bence Jones Proteins

A 
Multiple Myeloma (Ig Light chains in urine)
also see *Rouleax formation* of RBC stacking like poker chips
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2
Q

Rosenthal Fibers

A

Pilocytic Astrocytoma (childhood primary brain tumor) usually cerebellar, GFAP+

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3
Q

Reed Sternberg Cells

A

Hodgkins Lymphoma (aka “owls eye”) (CD15+ and CD30+)

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4
Q

Stary Sky appearance

A

Burkitts Lymphoma (8;14)

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5
Q

Homer-Wright Rosettes, small blue cells

A

Medulloblastoma (childhood cerebellar brain tumor)

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6
Q

perivascular pseudorosettes

A

Ependymoma (childhood 4th ventricle brain tumor)

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7
Q

Spindle cells in a whorled pattern, psammoma bodies

A

Meningioma (adult primary brain tumor)

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8
Q

Fried egg appearance

A

Oligodendroglioma (rare, adult, “chicken wire vasculature)

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9
Q

Leser-Trelat sign

A

sudden multiple sebhorric keratosis popping up, associated with GI or GU or lymphoid malignacy

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10
Q

MPO+, Auer Rods

A

AML t(15;17)

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11
Q

TdT+

A

ALL t(12;21) (not to be confused with trap+)

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12
Q

TRAP +

A

hairy cell leukemia (not to be confused with tdt+)

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13
Q

spindle shaped fibroblasts

A

ovarian fibroma (usually part of Meigs syndrome: ovarian fibroma, ascites, pleural effusion)

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14
Q

codman’s angle, sunburst pattern

A

Osteosarcoma
is: malignant proliferation of osteoblasts
at metaphysis of teens
pt may have defect of the retinoblastoma (Rb) gene which regulates G1–>S phase

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15
Q

soap bubble appearance

A

giant cell tumor

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16
Q

onion skin appearance of bone

A

ewings sarcoma t(11;22)

combank: “concentric formation of new bone layers in the periosteum”

17
Q

orphan annie eye nuclei

A

papillary carcinoma of the thyroid (most common)
risk factor: childhood irradiation
also has psammoma bodies

18
Q

Hurthle Cells

A

Hashimotos (autoimmune hypothyroid) also see germinal centers with lymphocytic infiltrate

19
Q

painful goiter

A

subacute (granulomatous) thyroiditis (aka dequervain’s)

the only one with a painful goiter – self-limiting hypothyroid following flu-like illness

20
Q

Call-Exner bodies

A

Granulosa cell tumors (call-exner bodies are small follicles filled with eosinophilic secretions)

21
Q

Schiller Duval bodies

A

glomerulus-like structures seen in Endodermal sinus tumors (aka yolk sac tumor)

22
Q

Reinke Crystals

A

Leydig cell tumor (can occur in men or women, secrete androgen, see hirtuism in women)

23
Q

signet ring cells

A

anything thats mucus producing (mucinous cells push nucleus off to the side)

24
Q

“jelly belly”

A

psuedomyxoma peritonei
tons of mucus in the peritoneum usually from mucinous tumor of the appendix
likes b/l mets to the ovaries
(Krukenberg tumor - the other mets to the ovaries, usually from diffuse gastric CA (mucinous as well))

25
Q

smudge cell

A

CLL

26
Q

Mallory Bodies

A

in liver; associated with alcoholic liver disease (probably the same guy who named Mallory-Weiss)

27
Q

Councilman bodies

A

in the liver; associated with apoptosis of virus infected hepatocytes

28
Q

Ferruginous bodies

A

in lung; associated with asbestos

stain Prussian Blue

29
Q

basophilic stippling in RBC

A 
lead poisoning (denatures ribonuclease so ribosomes can not be degraded) 
otherwise, sideroblastic anemia
30
Q

Kulchitsky cells

A

small cell lung cancer

31
Q

palisading nuclei

A

Basal cell carcinoma

32
Q

Lisch Nodules

A

Neurofibromatosis type 1 (von Recklinghausen disease)

these are pigmented iris hamartomas

33
Q

ringed sideroblasts

A 
sideroblastic anemia (microcytic)
these are iron rings in the mitochondria 
indicate defective heme synthesis dt decreased protoporphyrin bc its trapped in mitochondria

hereditary: D-ala-synthase defect
acquired: alcohol, lead, isoniazid

34
Q

charcot leyden crystals

A

asthma/parasitic infection (in sputum or stool if parasite)

35
Q

wire looping of capillaries under light microscope

A

diffuse proliferative glomerulonephritis (nephritic)

36
Q

subEPIthelial immune complexes

A

post strep glomerulonephritis (nephritic)

boards keep forgetting (8 decks)

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