Passmedicine

Question 1

ECG signs of PE (3)

Answer 1

Sinus tachycardia
T wave inversion in anterior leads
Signs of right heart strain

Question 2

Thiazides major side effects (6)

Answer 2

Gout
Impotence
Hypokalaemia
Hypercalcaemia
Dehydration
Postural hypertension

Question 3

What is Endothelin and its use

Answer 3

Long-acting vasoconstrictor and bronchoconstrictor

Useful in primary pulmonary hypertension

Question 4

Mechanism of Bendroflumethiazide

Answer 4

Inhibits sodium reabsorption by blocking Na+/Cl− symporter the distal convoluted tubule

Question 5

If someone with kidney stenosis cant tolerate ACEI and ARB what do you give (2)

Answer 5

Isosobide Mononitrate

Hydralazine

Question 6

If ACE serum levels are raised think off

Answer 6

Sarcoidosis

Question 7

Paraneoplastic features of small cell cancer (3)

Answer 7

ADH
ACTH - Hypertension, hyperglycaemia, hypokalaemia, alkalosis and muscle weakness
Lambert-Eaton syndrome

Question 8

Paraneoplastic features of squamous cell cancer (3)

Answer 8

Parathyroid hormone-related protein (PTH-rp) secretion - Hypercalcaemia
Clubbing
Hypertrophic pulmonary osteoarthropathy (HPOA)
Hyperthyroidism due to ectopic TSH

Question 9

Paraneoplastic features of adenocarcinoma (2)

Answer 9

Gynaecomastia

Hypertrophic pulmonary osteoarthropathy (HPOA)