part 8 MH meds Flashcards
atypical antidepressant, 2nd line, adjunct for tx of insomnia
trazodone
What is the one medication that is only a mood stabilizer?
lithium
What meds are mood stabilizers and anticonvulsants?
valproate valproic acid (Depakene) divalproex sodium (depakote) carbamazepine (tegratol) lamotrigine (lamictal) oxcarbazepine (Trileptal) Gabapentine (neurontin) topiramate (topamax)
What mood stabilizers/ anticonvulsants need blood levels drawn?
valproic acid (Depakene) divalproex sodium (depakote) carbamazepine (tegratol)
-also lithium
What does lithium need periodic blood draws?
narrow therapeutic range
What is the MOA of lithium?
- alters glutamate uptake and release
- blocks the binding of serotonin to its receptors
- and/or inhibits glycogen synthase
What are the AE of lithium?
-toxicity
- at therapeutic levels:
- tremor
- polyuria
- renal toxicity
- hypothyroidism (goiter)
- teratogenesis
- use in lactation
What mood stabilizer/anticonvulsant can cause steven johnson syndrome?
Lamotrigine (Lamictal)
First gen. antipsychotics low potency neuroleptics?
chlorpromazine (thorazine)
First gen. antipsychotics high potency neuroleptics?
haloperidol (haldol and fluphenazine (prolixin)
What are the AE’s causing great concern for antipsychotic drugs like haloperidol (haldol and fluphenazine (prolixin)?
Extrapyramidal symptoms (EPS)
- dystonic reactions
- parkinsonsim
- akathisia (internal restlessness)
- tardive dyskinesia (stop med immediately this can be permanent)
What scale can be used to measure EPS of antipsychotic drugs?
AIMS
abnormal involuntary movement scale
For what second generation atypical antipsychotic must you get blood drawn for?
clozapine (clozaril)
What is an AE of the second generation atypical antipsychotic clozapine (clozaril).
-immunosupression: can cause infection
