Part 2 Flashcards
Used to treat cardiac arrhythmia
Procainamide
Hepatic metabolite of the parent drug Procainamide
NAPA
N-acetyl procainamide
Used to treat generalized tonic clonic, simple, partial and complex partial seizures
Primidone
Two active metabolites of primidone
Phenobarbital and
Phenylethylmalonamide
Metabolite or cocaine
Benzoylecgonine
Where is benzoylecgonine eliminated?
Urine
What causes cocaine’s short life
Rapid hepatic hydrolysis to inactive metabolites
Where does Lead accumulate? (3)
RBCs, BONES and NEURAL TISSUES
Suitable for demonstrating lead toxicity (3)
Whole blood, Hair, and Urine
Specimen which gives greatest sensitivity to lead and can detect exposure over time
WHOLE BLOOD
Amount of lead in tubes with tan stoppers
No more than 0.25ug/dL
Effect of contamination (e.g. extracted nucleic acid or carryover amplicons) to PCR assay
False positive
What to do when contamination occurs in PCR assay
- All equipment and work surfaces must be cleaned
2. New rgts (inc. primers) must be used
Comparison of patient data with previous results
Delta checks
Detects specimen mix-up and other errors
Delta checks
When limit is exceeded during delta checks, mt must determine if due to
Medical change in patient or lab error
Formula for Coefficient of Variation (CV)
(SD/mean) x 100
The smaller the CV, the greater the___
Precision
Control values increasing or decreasing for 6 consecutive runs
Trend
What causes TREND
DETERIORATION OF REAGENTS/CTRL ; Progressive problem with the testing system or sample control
6 consecutive control values on the same side of the mean
SHIFT
What causes SHIFT
Sudden malfunction of an instrument
When a limit of 2 SD is used, 5% of expected assay results fall above or below the limit
REASSAY
Ctrls may deteriorate overtime when exposed to adverse temperatures or subjected to cx causing evaporation
Prepare NEW CONTROL and REASSAY
Rgts may have evaporated or become contaminated
Prepare fresh REAGENTS and reassay
Instrument may require repair
Recalibrate instrument
Commercial controls used to verify accuracy and reliability of patient test results
External QC
Electronic, internal, and procedural controls contained within the test system that ensures the reliability of the test system
Internal QC
Manager makes all decisions without input from others; Quick decision-making; least acceptance and commitment from staff.; Poorest quality decisions.
Authoritative
(+)
Manager makes decisions AFTER POOLING STAFF.; better quality and acceptance.
(-)
Decisions Takes longer. ; those in minority might feel ignored
DEMOCRATIC
Abbreviate MALDITOF
Matrix-assisted laser desorption-ionization time-of-flight
