Part 1, phil heywood, phsl Flashcards
function of sensory receptors of skin
convert physical stimulus into APs in primary sensory neuron / transduction
thermoreceptors
different types are activated at warm and cold temperatures, thermoreceptors are especially responsive to changing temperatures
proprioceptors sense
position of limbs by skin mechanoreceptors
touch receptors
sensitive to mechanical deformation
nociceptors sense what and respond to what
pain, respond to extreme mechanical, temperature and chemical stimuli
bare nerve endings sense
pain
meissners corpuscle sense
light touch
merkel disc sense
touch
Ruffini endings sense
stretch
pacinian corpuscle sense
pressure and vibration
sensory coding includes
modality, intensity, location and duration
modality
specificity of receptors for example touch vs temperature
intensity of sense is determined by
freq of APs in each axon
location of sense is determined by
mapping of receptive fields of individual primary afferents to specific cortical locations (somatotropic representation)
duration of sense is determined by
rapidly adapting receptors respond briefly, even if stimulus is sustained, detect movement, changing pressure. slowly adapting receptors signal true duration of stimuli
what is the axon path for pain and temperature
cross low in spinal cord, anterolateral of spinothalamic
axons for fine touch and proprioception
cross high in the medulla, dorsal column and medial lemniscal pathways
lateral inhibition
fundamental mechanism to increase accuracy of sensory information
what mediates lateral inhibition
inhibitory interneurons
lateral inhibition results in
centre surround inhibition
primary somatosensory cortex senses
nociception which is carried by two types of nerve fibres
C fibres in the primary somatosensory cortex
smallest diameter - unmyelinated
slow conduction velocity
signal ongoing damage
polymodal
A fibres in the primary somatosensory cortex
small diameter - myelinated
fast conducting velocity
signal acute onset of painful stimuli
primarily mechanoreceptors
hyperalgesia
pain pathways become more sensitive following injury of inflammatory disease
describe gating
gating of pain impulses by non-painful stimuli of nearby nerves
TENS
trans epidermal nerve stimulation
what are endogenous opiates
released from synapses natural analgesia for acute response to pain
what are endocannaboids
decrease long term sensitivity to pain, act on pain receptor
referred pain
feelings from viscera referred to body surface
two causes of phantom limb
ongoing activity in nerves that used to come from that body part
or
invasion of cortical representation from theat [art by intact body regions