Endocrine Flashcards
define the circadian rhythm
environmental rhythm determined by light
where is melatonin secreted
pineal gland, located at the base of the hypothalamus
what do the ant and pit gland regulate in the body
water balance
metabolism
body growth
milk secretion and reproduction
describe the hypothalamic control of the anterior pituitary
cell bodies located in the hypothalamus secret a hormone which acts on the ant pit which produces a hormone which acts on target cells in the body
media eminence
window to to the brain, interface between blood and CSF where many regulatory hormones are released.
describe the basis of the hypothalamic-pit axes
hypothalamus releases hormones which act on the ant pituitary which releases more hormones into the peripheral target tissue to produce a cascade of events.
describe the HPA axes of gonads
gonadotropin releasing hormone (GnRH) acts on follicular stimulating hormone (FSH) and luteinzing hormone (LH) which acts on the gonads to stimulate a response
describe the HPA axes of the adrenal gland
corticotropin releasing hormone acts on adrenocorticotropic hormone which acts on the adrenal glands.
describe the HPA axes of somatostatin
somatostatin negatively feeds back on GH
describe the HPA axes acting on the thyroid gland
thyroid releasing hormone acts on thyroid stimulation hormone which acts to produce a response from the thyroid gland.
describe the HPA axes on the liver
growth hormone releasing hormone acts on growth hormone which acts on the liver to produce IGF-1 which has metabolic and growth effects which are both direct and indirect
how is the GHRH axes stimulated
exercise, sleep, fasting and stress
describe the release of GH
diurnal pulsatile release however not a true circadian rhythm
control of GH secretion
IGF-1 negatively feedback on growth hormone to inhibit secretion
describe the cascade of events that occurs when GH binds to the GHRH receptor/ G protein
AC is bound to the receptor which causes ATP-cAMP this energy released is used to activate PKA, PKA then acts on Ca2+ channel causing an influx of ions into the cell which causes GH to be released.
how does somatostatin affect the GH G protein cascade
SS acts on AC to inhibit the ATP-cAMP dephosphorylation preventing the release of GH
what are the indirect growth effects of GH in the body
stimulates bone growth, by the stimulation of mitogenesis via IGF-1
what are the indirect growth effects of GH in the body
stimulates protein synthesis which directly acts on muscle growth
what are both of the direct metabolic effects of GH
increase in blood glucose by stimulating glucose synthesis in liver an inhibiting cellular glucose uptake
increase in TAG breakdown and ffa mobilisation in adipose tissue
what two hormones does the posterior pit produce
vasopressin and oxytocin
why is vasopressin released
secreted in response to increased plasma osmotic pressure or decreased blood pressure
one word to describe vasopressin
anti-diuretic
what are the effects of vasopressin
inhibits urine production and vasoconstriction