Part 1

Question 1

Body surface area

Answer 1

4w+7/wt+70

Question 2

Creatinine clearance

Answer 2

140-agex wt in kg/ 70+s creatinine in mg/dl

If female x.85

Question 3

gene arrangement in nsclc

Answer 3

Kras mutation
Egfr muta
Pten mut
Alk mut
Her2
Pik3ca
Akt
Braf 
Ret, mek, nras, ros 1

Question 4

Targeted drug in nsclsc

Egfr,alk, ros, braf, met, ntrk

Answer 4

Egfr- gefitinib, erlotinib, afatinib, osimertinib
Alk- crizotinib, alectinib, brigaatinib
Ros1- crizotinib, entrectinib
Braf- dabrafenib, trametinib
Met-capmatinib, repotinib
Ntrk- larotrectinib, entrectinib
Ret- pralsetinib, selpercatinib

Question 5

Agent causing neutropenia

Answer 5

Alkylating
Anthra
Platinum

Question 6

Bone tumor classify

Answer 6

Hematogenic
Chondrogenic
Osteogenic
Unknown
Lipogenic
Fibrogenic
Vascular

Question 7

High risk emetic chemo

Answer 7

AC combination
Cpl
Carbo auc)4
Cyclophosphamide) 1.5gm/m2
Ifos 2gm/m
Temozolomide carmustine
Doxo more than 60mg/m2
Epirubicin 90mg/m2

Question 8

Irritant drug

Answer 8

Alkylating agent: cpl, carbo, oxali, cyclophosphamude, ifosfamide,
Antimetabolite: mtx, cladribine, fludarabine, 5fu,
Bleomycin, etoposide, irinotecan, paclitaxel, docetaxel

Question 9

Vesicant drug

Answer 9

Doxo, dauno, epirubicin
Vinca
Mitoxsantrone

Question 10

Drug causing diarrhea

Answer 10

5fu, irinotecan, capecitabine, cytarabine, docetaxel, paclitaxel, interferon, il-2

Question 11

drug causing hand foot syndrome

Answer 11

5fu, liposomal doxorubicin, capecitabine
Cytarabine
Cabozantinib
Regorafenib
Sunitinib, axitinib, lapatinib

Question 12

Radiation recall drug

Answer 12

Doxo dauno
Pacli doce
Etposide
Bleomycin
5fu, capecitabine, gemcitabine
Cyclo, lomustine, melphalan

Question 13

Let value of
Alpha
Xray
Co60
Electron

Answer 13

Alpha 260 kev/um
Co60- 0.2-2
Xray. 4-36
Electron. 25

Question 14

Half life of radionuclide
Co60
Iodine 125
Iodine 131
Iridium 192

Answer 14

Co60—5.26yrs
I 125—-60days
Iodine 131—-8days
Iridium 192—–74 days

Question 15

B hcg

Normal level

Answer 15

5miu/ml
Gtt, hydatiform mole, ovarian non seminamatous germ cell tumor
Benign: pregnancy

Question 16

Alpha fetoprotein
Normal
Malign
Ben

Answer 16

6ng/ml
Hcc, non seminomatous germ cell tumor, testicular teratoma
Benign: pg, neural tube defect

Question 17

Cea
Normal
Malig
Ben

Answer 17

2.5 ug/l
Crc
Ben: ssmokers, cirrhosis, chronic hepatitis,. Ulcerative colitis, pneumonia

Question 18

Psa
Normal level
Mali
Benign cause

Answer 18

4 ng /ml
Prostate cancer
Bep, acute prostatis, infarction

Question 19

Ca 125
Mali
Benign

Answer 19

Epithelial ovarian cancer, git, lung

Mens,pg, fibroid, pid

Question 20

Ca 19-9
Normal level
Malignant
Benign

Answer 20

37u/ml
Pancreatic, mucinous tumors of ovary, gastric cancer, colon cancer
Cirrhosis, cholestasis,. Pancreatitis

Question 21

Ca 15-3
Normal level
Benign
Malignant

Answer 21

30iu/ml
Ca breast, adenocarcinoma of lung, colon ovary pancreas
Ben: smokers, chr hepatitis, liver cirrhosis, sarcoidosis, tb

Question 22

Ldh
Normal
Causes

Answer 22

140-280u/l

Gct,leukemia,lymphoma, melanoma, neuroblastoma

Question 23

Drug causing pulmonary toxicity

Answer 23

Cyclo, bleomycin, mtx
Gemcitabine,  
Egfr
Mtor
Bevaci trastu

Question 24

Screening age
Cervical
Breast
Crc

Answer 24

21-29, 30-65
40-44,45-55
>50

Question 25

Bevacizumab indication

Answer 25

Breast colon kidney rectum nsclc Gbm Ovary fellopian Cervical

Question 26

Maltoma type of lymphoma

Answer 26

B cell nhl

Question 27

Rituximab indication

Answer 27

``` Follicular, dlbcl cd20+ve CLL RA Microscopic polyangitis Wegeners granulomatosis ```

Question 28

``` Alara principle dose limit Uncontrolled Supervised Cobtrolled Restricted ```

Answer 28

Un <1usv/hr Sup <3 usv/hr Cont>3usv/hr Restricted > 10usv/hr

Question 29

Background radiation

Answer 29

``` External radiation Cosmic ray. 44msv External gamma ray. 40msv Internal rad. 18 msv Total 1.02msv ``` Man made Total. 80 Total.2.0 msv

Question 30

nuclide used in brachytherapy

Answer 30

``` Ra 226- 1600years Cs 137-- 30 yrs Co 60- 5.26 yr Ir 192- 74 days Iodine 125- 60days Palladium 103- 17 days ```

Question 31

``` Radiation weighhting factor Photons Electrons Protons Alpha particle Neutrons ```

Answer 31

``` Photons 1 Electrons 1 Proton 2 Alpha particle 20 Neutros continuous ```

Question 32

``` Tissue weighting factor Bm, colon, lung Gonads Bladder oesophagus, liver thyroid Bone surface, brain, skin salivary gland ```

Answer 32

Bm, colon--- 1.2 Gond----. O8 Bladder oesophagus liver thyroid ----. 04 Bone surface. 01

Question 33

``` LET of Alpha Co60 200 kvp xray Electron Neutron ```

Answer 33

``` Alpha 260 Co 60. 2--2 200kvp xray---.4-36 Electron:---.25 Neutron:----60 ```

Question 34

Cell cycle duration

Answer 34

G1=4-6 hours/ variable S= 6-8 hr G2= 2-4 hr ( 4- 6 ) nazir M= 0.5-1 hr

Question 35

Tenth value layer for cobalt 60, linac 6 mv machine

Answer 35

For cobalt 60: Lead : 4 cm, concrete 20 cm 6mv: Lead 5.1 cm, concrete 34 cm