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exam Orient > Part 1 > Flashcards

Part 1 Flashcards

1
Q

Body surface area

A

4w+7/wt+70

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2
Q

Creatinine clearance

A

140-agex wt in kg/ 70+s creatinine in mg/dl

If female x.85

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3
Q

gene arrangement in nsclc

A 
Kras mutation
Egfr muta
Pten mut
Alk mut
Her2
Pik3ca
Akt
Braf 
Ret, mek, nras, ros 1
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4
Q

Targeted drug in nsclsc

Egfr,alk, ros, braf, met, ntrk

A 
Egfr- gefitinib, erlotinib, afatinib, osimertinib
Alk- crizotinib, alectinib, brigaatinib
Ros1- crizotinib, entrectinib
Braf- dabrafenib, trametinib
Met-capmatinib, repotinib
Ntrk- larotrectinib, entrectinib
Ret- pralsetinib, selpercatinib
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5
Q

Agent causing neutropenia

A

Alkylating
Anthra
Platinum

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6
Q

Bone tumor classify

A 
Hematogenic
Chondrogenic
Osteogenic
Unknown
Lipogenic
Fibrogenic
Vascular
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7
Q

High risk emetic chemo

A 
AC combination
Cpl
Carbo auc)4
Cyclophosphamide) 1.5gm/m2
Ifos 2gm/m
Temozolomide carmustine
Doxo more than 60mg/m2
Epirubicin 90mg/m2
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8
Q

Irritant drug

A

Alkylating agent: cpl, carbo, oxali, cyclophosphamude, ifosfamide,
Antimetabolite: mtx, cladribine, fludarabine, 5fu,
Bleomycin, etoposide, irinotecan, paclitaxel, docetaxel

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9
Q

Vesicant drug

A

Doxo, dauno, epirubicin
Vinca
Mitoxsantrone

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10
Q

Drug causing diarrhea

A

5fu, irinotecan, capecitabine, cytarabine, docetaxel, paclitaxel, interferon, il-2

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11
Q

drug causing hand foot syndrome

A 
5fu, liposomal doxorubicin, capecitabine
Cytarabine
Cabozantinib
Regorafenib
Sunitinib, axitinib, lapatinib
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12
Q

Radiation recall drug

A 
Doxo dauno
Pacli doce
Etposide
Bleomycin
5fu, capecitabine, gemcitabine
Cyclo, lomustine, melphalan
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13
Q 
Let value of
Alpha
Xray
Co60
Electron
A

Alpha 260 kev/um
Co60- 0.2-2
Xray. 4-36
Electron. 25

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14
Q 
Half life of radionuclide
Co60
Iodine 125
Iodine 131
Iridium 192
A

Co60—5.26yrs
I 125—-60days
Iodine 131—-8days
Iridium 192—–74 days

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15
Q

B hcg

Normal level

A

5miu/ml
Gtt, hydatiform mole, ovarian non seminamatous germ cell tumor
Benign: pregnancy

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16
Q

Alpha fetoprotein
Normal
Malign
Ben

A

6ng/ml
Hcc, non seminomatous germ cell tumor, testicular teratoma
Benign: pg, neural tube defect

17
Q

Cea
Normal
Malig
Ben

A

2.5 ug/l
Crc
Ben: ssmokers, cirrhosis, chronic hepatitis,. Ulcerative colitis, pneumonia

18
Q

Psa
Normal level
Mali
Benign cause

A

4 ng /ml
Prostate cancer
Bep, acute prostatis, infarction

19
Q

Ca 125
Mali
Benign

A

Epithelial ovarian cancer, git, lung

Mens,pg, fibroid, pid

20
Q

Ca 19-9
Normal level
Malignant
Benign

A

37u/ml
Pancreatic, mucinous tumors of ovary, gastric cancer, colon cancer
Cirrhosis, cholestasis,. Pancreatitis

21
Q

Ca 15-3
Normal level
Benign
Malignant

A

30iu/ml
Ca breast, adenocarcinoma of lung, colon ovary pancreas
Ben: smokers, chr hepatitis, liver cirrhosis, sarcoidosis, tb

22
Q

Ldh
Normal
Causes

A

140-280u/l

Gct,leukemia,lymphoma, melanoma, neuroblastoma

23
Q

Drug causing pulmonary toxicity

A 
Cyclo, bleomycin, mtx
Gemcitabine,  
Egfr
Mtor
Bevaci trastu
24
Q

Screening age
Cervical
Breast
Crc

A

21-29, 30-65
40-44,45-55
>50

25
Q

Bevacizumab indication

A

Breast colon kidney rectum nsclc
Gbm
Ovary fellopian
Cervical

26
Q

Maltoma type of lymphoma

A

B cell nhl

27
Q

Rituximab indication

A 
Follicular, dlbcl cd20+ve
CLL
RA
Microscopic polyangitis
Wegeners granulomatosis
28
Q 
Alara principle dose limit
Uncontrolled
Supervised
Cobtrolled
Restricted
A

Un <1usv/hr
Sup <3 usv/hr
Cont>3usv/hr
Restricted > 10usv/hr

29
Q

Background radiation

A 
External radiation 
Cosmic ray. 44msv
External gamma ray. 40msv
Internal rad. 18 msv
Total 1.02msv

Man made
Total. 80
Total.2.0 msv

30
Q

nuclide used in brachytherapy

A 
Ra 226- 1600years
Cs 137-- 30 yrs
Co 60- 5.26 yr
Ir 192- 74 days
Iodine 125- 60days
Palladium 103- 17 days
31
Q 
Radiation weighhting factor
Photons
Electrons
Protons
Alpha particle
Neutrons
A 
Photons 1
Electrons 1
Proton 2
Alpha particle 20
Neutros continuous
32
Q 
Tissue weighting factor
Bm, colon, lung 
Gonads
Bladder oesophagus, liver thyroid
Bone surface, brain, skin salivary gland
A

Bm, colon— 1.2
Gond—-. O8
Bladder oesophagus liver thyroid —-. 04
Bone surface. 01

33
Q 
LET of
Alpha
Co60
200 kvp xray
Electron
Neutron
A 
Alpha 260
Co 60. 2--2
200kvp xray---.4-36
Electron:---.25
Neutron:----60
34
Q

Cell cycle duration

A

G1=4-6 hours/ variable
S= 6-8 hr
G2= 2-4 hr ( 4- 6 ) nazir
M= 0.5-1 hr

35
Q

Tenth value layer for cobalt 60, linac 6 mv machine

A

For cobalt 60:
Lead : 4 cm, concrete 20 cm
6mv:
Lead 5.1 cm, concrete 34 cm

exam Orient (6 decks)

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