Part 1 Flashcards
Some methods of BT. 1. Systematic desensitisation
- Assumes that irrational fears and other forms of anxiety tend to decrease with continued exposure to fearful stimulus.
- The method is based on principles of classical conditioning, discovered by Russian psychologist Ivan Pavlov
- CC is a form of learning in which a neutral stimulus is paired with another (unconditioned) stimulus that naturally provokes a certain response. After several reputation the neutral stimulus becomes a conditioned stimulus and evokes similar response.
- It is used in treatment of phobias
Types of Hypomnesias
Physiological - in healthy people is observed in cases of physical and especially mental fatigue. Disappears after taking a rest. Permanent physiological hypomnesia occurs in people of advanced age.
Pathological - It is also divided into transient (in depression) and permanent (in intellectual disability, dementia). It is of the earliest symptoms
Define perception
Is a complex process of receiving information from the environment through our sensorial organs.
What are tranquillisers?
Benzodiazepines
Three core conditions are necessary and sufficient to promote change and growth. (humanistic approach)
- Empathy - understanding the client’s experience from their perspective
- unconditional positive regard - (the client is free to express any feelings, however negative, hostile or ambivalent they might be, without fear of rejection on the part of the therapist)
- Congruence - (the therapist to be as authentic and genuine as possible)
What is ambivalent (dual) thinking?
Intermediate between form and content of thought
Is the simultaneous occurrence of conflicting thoughts, attitude and decisions regarding the same object or situation. Usually it is combined with ambitendency (of, impulses, decisions and actions)
Schizophrenia - they experience both love and hatred for his father (ambivalence) who often comes to visit. When you try to shake hands with him, the patient hardly gives his hand, rapidly pulls it back (ambitendency)
What are the BDs alternatives?
1 . NON BD hypnotics
- SSRIs
- Pregabalin
- Hydroxyzine
- Etifoxine
- Low dose typical Aps and tricyclic antidepressants.
- Beta blockers
Psychodynamic therapy.
- Psychodynamic psychotherapy seeks the implementation of self-transformation and reconstruction of the individual through exploration of the unconscious roots of mental emotional problems and problematic behaviours.
Normal functioning of client can be restored only through: - Awareness of unconscious conflicts
- use of causal understanding (insight)
There are techniques for both
What are Low-potency typical APs?
- Chlorpromazine, Chlorprothixene, Thioridazine)
- They also block substantially histamine, muscarinic acetylcholine (M1) and Alpha 1 adrenergic receptors in the brain
- All the above causes mild antipsychotic effect, anticholinergic effects, sedation and orthostatic hypotension.
- They are also termed “broad-spectrum” or “sedative” neuroleptics
- they are useful in psychomotor agitation and generally begin to exert a true antipsychotic effect at relatively higher doses.
Cognitive therapy (CT)
- Focuses on identifying and changing specific maladaptive thought patterns.
- CT assumes that the person’s emotional reactions are produced not directly by the life events but the thoughts of the person in response to the events but by the thoughts of the person in response to the events.
- Negative explanations of events and ruminating on negative and thoughts sustain bad mood and could lead to depression. EX “I did not get the job, i am not good for anything” CT is considered most useful therapy for depressive disorders
How many neuronal pathways are formed by dopaminergic neutrons?
4
- Mesolimbic pathway
- Mesocortical pathway
- Nigrostriatal pathway
- Tuberinfundibular pathway
Describe the EPS adverse effects. Neuroleptic malignant syndrome.
- This is a life-threatening neurological disorder
- Characterised by quantitative and qualitative alternations of consciousness (agitation, delirium, coma)
- Extreme muscle rigidity, fever and autonomic instability (hypertension, tachycardia)
- IT is rare and usually develops at high AP dose, after a hurried switch to APs or when multiple AP drugs are used simultaneously
- This condition requires an immediate discontinuation of the offending AP and life support measures. Mortality rate is high.
Catatonia diseases?
neurodevelopment disorders, psychotic, bipolar, depressive disorders
What are physiological hallucinations? And types
They are regular companions of our dreams
Hypagogic hallucinations occur immediately before falling asleep
Hypnopompic are characteristic for the time of waking up.
What is Alexithymia?
Closely related to emotiona intelligence. It is a deficiency in understanding, processing or describing own emotions. Such individuals often express their fears and bad mood through somatic symptoms
Individuals suffering form Alexithymia also have difficulty distinguishing and appreciating the emotions of others, which leads to abnormal emotional responding.
What are antipsychotics?
Are used in treatment of the psychotic symptoms (delusions, hallucinations, disorganised speech and grossly disorganised behaviour) as well as the management of psychomotor agitation associated with schizophrenia and other psychotic disorders.
Describe disturbance in memory. Types.
Memory is the ability of the brain to encode (registration), store (retention) and reproduce (reproduction/recall) traces of sensations, perceptions, thoughts and other experiences.
- Quantitative - hypermnesia, hypomnesia and amnesia)
- Qualitative - Almonesia, pseudomnesia and confabulation
Diagnosis of delirium
Delirium can be associated with various somatic diseases (metabolic, systemic infections, hypoxia, hypoglycaemia, fluid and electrolyte imbalance, renal diseases etc)
- substance intoxication
- substance withdrawal
How many models in psychotherapy?
There are 4 major theoretical models (approaches) in contemporary psychotherapy
- The psychodynamic
- Behavioural and cognitive behavioural
- Humanistic
- The family models
The therapeutic relationship aims to clarify the nature of client problems, to learn new ways of thinking and expression of feelings, to try out new behaviours.
some approaches are specific and some are integrative (new theoretical perspective and techniques)
Kinds of flow of thought - Speed
Speed -
Accelerated (tachypsychia) - accelerated formation of new and fast reproduction of old associations, quick shifting from one topic to another - MANIA
Slowed (Bradipsychia) - Flow of thought is painful, poor and repetitive, speech is quiet and monotonous
Adverse effects of APs. EPS
- Extrapyramidal adverse effects (EPS)
- Hyperprolactinemia
- Metabolic syndrome
- CV side effects
- Other adverse effects.
What is Korsakoff’s syndrome?
- Severe impairment of registration, leading to anterograde amnesia with inability to acquire new memories
- Disorientation to time, place and public events
- Confabulations whereby patients fill the gaps in their memory.
Occurs in organic impairment of the central nervous system - dementia, chronic alcoholism, trauma, intoxication
What is psychotherapy?
- It is a general term, with literal meaning of “healing of the mind”
- it takes place between two individuals where one is believed to be in psychological distress and chooses to discuss it with another one, (therapist)
- Therapist can work with families, groups and couples as well.
Is a process of helping people with mental health problems to implement changes in their thinking and behaviour, and to resolve tensions and conflicts.
Quantitative disturbances of emotions.
Hyperthymia - an emotional state, characterised by pathologically elevated aesthetic emotions - excessive cheerfulness and joy or intense anger. Characteristic of mania
Dysthymia - An emotional state. Characterised by pathologically elevated asthenic (lack of energy, low) emotions - anxiety, sadness - characteristic of typical depression
Hypothymia - Reduced emotional tone and low emotional reactivity
Apathy - a complete loss of emotional reactivity. Together with abulia it is part of the apathetic abulic syndrome, characteristic of front lobe organic disorder.
Disturbances of emotions. Definition and types.
Disturbance in interaction of human individuals with the environment - humans experience emotions as either pleasant or unpleasant depending on their attitude to the environment and the satisfaction of their needs.
Emotions reflect the attitude of individual to the surrounding environment or situation. They have specific significance to the individual.
Cerebral cortex and limbic system are the primary anatomical physiological substrates of emotions.
- Qualitative and Quantitative
What is a monoamine hypothesis?
- Hypothesis of depression that disorder is cause day a deficiency of the neurotransmitter (NTs) involved in the regulation of mood - Serotonin, noradrenaline and dopamine.
Overvalued ideas.
Disturbances of thought content.
Are overestimations of real circumstances important to the individual (e.g. one’s own abilities, the mistakes made)
They are experienced with great emotional intensity and they intervene in their ability of patient to have reasoning and conclusions about ideas. (Their thinking is dictated by their mood - catathymic ideas) - leads to altered view of number of issues.
Over-valued can be positive (people in love idealise their partners, authors overestimating their work) or negative (student fear of failure even though they have prepared, mother fear of child getting disease).
Severe OV ideas can be morbid phenomena. They are characteristic of personality disorders - can lead to full blown delusions (Psychosis)
What is depersonalisation?
It is a disturbance in one’s experience and awareness of self (in sense of self) - feeling of detachment or estrangement from one’s mental processes or body
Individual feels automatised or as if he/she is in a dream or movie.
They feel as if they are not the same or they have lost them selves.
What is classification?
- Classification is taxonomic nomenclature system established for the purpose of statistical analysis of the phenomena and in order to facilitate and uniform the language of professionals in different countries.
Methods of BT 2. Progressive relaxation training
- involves tensing and relaxing various muscle groups
- The aim is to reduce the tension in muscles, the heart rate and blood pressure
- and to reach emotional calmness
What are dissociative disorders. Dissociative fungue
Dissociative Fungue - Is a sudden unexpected, travel usually caused by traumatic, stressful or overwhelming life events. The travel may range from brief trips (hours or days) to long (weeks or months) wandering, crossing numerous national borders and traveling thousands of miles.
During a fungue, individuals generally appear to be without psychopathology and do not attract attention.
Recovery is usually rapid and there may be no memory for the events that occurred during the fungue and amnesia for the traumatic events that caused the fungue e.g. after termination of a long fungue, a soldier remains amnesic for the wartime events in which the soldiers closest friend was killed.
Obsession and Compulsion. Obsession.
Both are disturbances in thought content.
Obsessions are persistent ideas, thoughts, doubts, fears, memories, impulses or images that are experienced as intrusive and inappropriate. Individual senses that content of obsession is alien, not within their control and against their will and not the kind of thought they should have.
Some examples: becoming contaminated by shaking hands, need for things in particular order, intrusive counting things like steps, roadside lamppost etc, intrusive religion of names of things or definitions
Adverse effects of APs. 2. Hyperprolactinemia
- Is caused by D2 receptor blockade in the tuberoinfundibular pathway is more common with typical APs
- In women significant rise in prolactin are associated with amenorrhoea, galatorrhoea and infertility.
- Lesser degrees of hyperprolactinemia are associated with sexual dysfunction in both genders.
What are the valid reasons for discontinuation of BDs?
- Increase in symptoms that have been adequately controlled
- Memory or other neurocognitive impairments
- Alcohol, cocaine or medication abuse.
What is Mesolimbic pathway?
It is formed by dopaminergic neurons located in the unclei of the mesencephalon that sends projections to the limbic system
- These neurons subserve mental processes such emotions, drives and satisfaction from pleasurable activities.
- Increased dopaminergic function in the mesolimbic pathway is hypothesised to be responsible for the psychotic (positive) symptoms of Schizophrenia.
- By blocking D2 receptors in the mesolimbic pathway APs effectively reduce psychotic symptoms.
What is Nosology?
- Is a division of medical diagnostic committed to explanation and categorisation of nosographic entities
Define dissociative disorders. What are they?
The essential feature of dissociative disorders is dissociation in the usually integrated functions of consciousness, memory, identity and perception of the environment. they are
- Dissociative fungue
- Trance
- Possession trance
BD alternative. Low dose APs and Tricyclic antidepressants.
- Have traditionally been prescribed as alternatives to BDs.
- In view of their greater toxicity (EPS, anticholinergic, antihistamine and antiadrenergic side effects) these drugs appear to be no safer choice weighed against the risk of dependence with BDs.
- Atypical APs have lower potential for EPS have been used as adjunctive treatment of treatment refractory anxiety disorders.
Give some of the examples in medicine records of psychomotorics
Patient doesn’t speak (mutism)
patient doesn’t answer (negativism)
patient has immobility (stupor)
consciousness altered (delirium)
Qualitative disturbances of emotions. Part 2. Fear, anxiety, agitation, panic
- Fear - an unpleasant emotional state that involves psychophysiological changes in response to the real threat or danger. Varying degrees of intensity may be observed. From mild fear to horror. It is often protective for the individual and may be considered a normal sate. Pathological fears can be observed in anxiety disorders, psychotic disorders (secondary to delusions or hallucinations)
- Anxiety - a feeling of apprehension in the anticipation of a possible threat or a vague menace. It is experienced in absence of threatening stimulus (unlike fear). Anxiety is more diffuse. It is accompanied by physical sensation - lump in the throat, knot in the stomach and others. It’s common in anxiety disorders and depression, psychosis, personality disorders, substance withdrawal.
- Agitation - a state of motor restlessness resulting from severe anxiety; patients walk aimlessly around the room, sit and stand repeatedly, perform stereotypical actions.
- Panic - an acute, intense attack of anxiety and discomfort accompanied by manifest symptoms of autonomic arousal. The anxiety is overwhelming and may be associated with a sense of impeding doom. Panic attacks occur in panic disorders and phobias.
What are physiological illusions?
They are normal illusions caused by fatigue, forgetfulness, poor visibility, psychological attitudes, tense anticipation and especially strong emotions (fear)
Cognitive-behavioural therapy
- It combines the cognitive therapy technique of changing negative or distorted thought patterns with the behaviour therapy techniques of changing maladaptive or disruptive behaviours by learning and practicing new skills.
- CBT encourages awareness of the irrational negative thinking and the way it influences the emotions and behaviour.
- CBT stems from the basic assumption that when the thoughts are negative, they will produce negative, faulty beliefs thus creating emotional disturbance.
- The therapist then will try to identify those beliefs.
- Next step are learning how thoughts influence behaviour; identifying automatic thoughts (negative messages in situations traditionally leading to negative feelings) and confronting the fears or anxiety provoking situations (exposure or desensitisation)
- Other commonly employed techniques are role playing, diary keeping, relaxation techniques and others.
Describe the course of delirium
- It develops of hours to days, rarely abruptly (e.g. after a head injury) Delirium tends to fluctuate during the course of the day e.g. during morning rounds, the person may be coherent and cooperative but at night insists on pulling IV lines and going home to parents who died years ago.
It can last about a week
Describe tuberoinfundibulnar pathway
Comprises dopaminergic neurons, located in the hypothalamus, that send projections to the anterior art of the pituitary gland and inhibit prolactin release by the pituitary.
- By blocking D2 receptors in the tuberoinfundibular pathway, APs may release prolactin secretion from dopamine inhibition and cause hyperprolactinemia
What are pathological illusions?
Individuals firmly accept the distorted perception of an object to be reality.
Examples: delirium syndrome (rarely in cases of schizophrenia and other psychosis)
Illusions can be visual, auditory, olfactory, gustatory and tactile.
Adverse effets of APs. 4. CV effects
- The metabolic adverse effects of APs can lead to higher risks of arterial hypertension, atherosclerosis and vascular incidents.
- APs may also increase the risk of arrhythmias, thrombotic and thromboembolic events.
Compulsions
Are repetitive types of behaviour (e.g. hand washing, ordering, checking) or mental acts (e.g. praying, counting, repeating words silently), the goal is to prevent anxiety or distress that accompanies in obsession.
The patient recognises that both compulsion is obsession is not normal and painfully attempts to resist them, the inability causes marked anxiety or distress and it is one of the most distressing states in psychiatry.
Disturbance in form of thought? What is disorganised (loose) thinking?
Is a form of thinking with coarsely broken logical connection between words arranged in grammatically correct sentences
“How are you feeling?”
“Because the sun is growing in our house”
One can find words that are new and none-existent in the language.
Examples: schizophrenia
Typical Antipsychotics
- Pharmacologically, atypical APs (clozapine, olanzapine, quetiapine, risperidone, paliperidone, ziprasidone, sertindole, aripiprazole, amisulpride)
- They not only block D2 receptors but also serotonin type 2A receptors (5HT2A)
- 5HT2A are expressed on the cell bodies and axons of dopaminergic neurons - normally endogenous serotonin agonist blocks the dopamine release.
- These drugs block those receptors and release the dopamine in the 4 dopamine pathways.
- They are as efficacious with positive symptoms of schizo but cause less hyperprolactinemia and fewer EPS than typical APs, they do not worsen the negative symptoms of Schizo.
- They also act as either agonist or antagonist in variety of receptors in the brain (dopamine, serotonin, muscarinic, adrenergic)
What are the differences between delusional and over valued ideas?
Delusional ideas cannot be corrected by logical persuasion or personal experience, unlike obsessional thoughts the patient has no critical attitude towards them.
Describe the EPS adverse effects. 1. Parkinsonism
- Parkinsonism
- This develops in the first days and weeks after initiation of treatment.
- Characterised by typical clinical triad of tremor, rigidity and hypokinesia.
- It responds to AP dose reduction, the addition of anticholinergic medications (biperidene) or a switch to an atypical antipsychotic.
Methods of BT 3. modelling
- Is a type of learning new behaviour by watching and imitating others
- Therapist could teach clients desirable behaviour by demonstrating this behaviour
e. g. Therapist shows the patient how to keep calm in anxiety provoking situations or shows special filmed movies - It is an important part of social skills training and training of assertive behaviour, ex: coping in social situations, communicating more effectively, expressing freely etc.
What are the contraindications of BDs?
BD use is absolutely contraindicated in myasthenia graves, severe respiratory disease, sleep apnoea, and probably also in pregnancy.
what are the main symptoms of Catatonia?
Stupor - no psychomotor activity; not actively relating to environment.
Catalepsy - Passive induction of a posture held against gravity
waxy flexy - slight, even resistance to positioning by examiner
mutism - no or very little verbal response
negativism - opposition or no response to instructions or external stimuli.
posturing - spontaneous and active maintenance of a posture against gravity
mannerism - odd, circumstantial caricature of normal actions.
Stereotypy - repetitive, abnormally frequent, non-goal- directed movements
agitation - not influenced by external stimuli
Echolasia - mimicking another’s speech
Echopraxia - mimicking movements
What are physical illusions?
They are caused by physical properties of environment around someone. For example light propagation laws - e.g. mirages in desert; spoon that looks as if its broken when half submerged into water and so on.
what is volition?
Volition is a state of energy and impulse, which guides our purposeful activity of the mental and physical activity.
3 stages:
- Choosing a purpose
- Making a decision after a struggle of motive and counter - motives.
- Implementing the decision - acting or refraining from action in order to achieve the purpose.
Describe Mesocortical pathway
It is formed by dopaminergic neurons located in the uncle of the mesencephalon and send projections to the cerebral cortex (most importantly, the frontal lobe)
- These neurons participate in mental processes such as attention, motivation, socialisation, planning and initiation of activities.
Decreased dopamine function in the mesocortical pathway is hypothesised to be responsible for the negative symptoms schizophrenia (emotional flattening, apathy, lack of initiative, associality and poverty of speech) - by blocking D2 receptors in the mesocortical pathway, some APs may worsen the negative symptoms of schizophrenia.
Adverse effects of BDs?
- Anterograde amnesia seldom causes clinical significant dysfunction
- Sedation, somnolence
- Sensorimotor impairement in healthy subjects (although may improve it in anxiety patients)
- Gradual accumulation of psychoactive metabolites during continuous treatment may put patient at risk during machinery operation or driving.
- Physical dependence
Adverse effects of APs. 5. Other adverse effects
- Less frequent adverse of APs include epileptic seizures, hepatotoxicity, toxic myocarditis and pancreatitis, blood dycrasias, etc.
- Potentially fatal agranulocytosis has been reported in less than 1% of clozapine treated patients.
- Blood cell counts are warranted weekly in the first 6 months of treatment and at least monthly thereafter in clozapine treated patients.
Disturbance in form of thought? What is incoherent (uncoordinated) thinking?
Is a heavy disintegration of thinking - the grammatical structure of sentences is coarsely disrupted along with the logical one. Single parts of sentences or even single words (the so called verbal salad) are “tangled” together without any sense
Occurs on the background of altered consciousness
Delirium
What is a transient and permanent physiological hypermnesia?
Permanent - innate feature of individual
Transient - observed in people who have experienced danger of death, or any other feat for their life
Contraindication of APs
- Absolutely contraindicated in patients with hypersensitivity, neuroleptic malignant syndrome and coma
- APs should not be used in patients with delirium
- Should be used carefully in Parkinson’s disease, history of neuroleptic malignant syndrome, epilepsy, blood dycrasias, rhythm and conduction disturbances, in heart failure, respiratory, hepatic and renal insufficiency as well as in febrile and elderly people.
- In pregnant women APs are to be used only if the perceived benefits outweigh the risk for the developing foetus.
Quantitative disturbances of consciousness.
- Obnubilation - cloudy, gloomy
- Somnolence - sleep, sleepiness
- Sopor - Profoundly deep sleep, stuporouness
- Coma - deep sleep, unconscious state
Only vital unconditional reflexes are cardiovascular and respiratory are kept, when the cause of coma cannot be eliminated, they are also suppressed and death occurs.
observed in organic damages to the central nervous system (infection, intoxications, traumas, strokes, tumours, metabolic disturbances)
What are the types of disturbance of perception?
- Illusions
- Hallucinations
- Dissociative phenomena