Part 1 (1-150) Flashcards
1
Q
Agency in the US responsible for selecting
appropriate nonproprietary names for drugs
A
USAN
2
Q
Official standards for individual drugs and
chemicals formulated into dosage forms are
published in the
A
USP/NF
3
Q
Descriptions of the Federal Controlled
Substances Act, Approved Drug Products
with Therapeutic Equivalence Evaluations,
and USP/NF dispensing requirements may
be found in the
A
USP DI Volume III
4
Q
Prescription drug descriptions expressed in a
layperson’s terms and useful as handouts for
patients may be photocopied from
A
US DI Volume II
5
Q
Most frequently dispensed dosage form in
the US
A
Oral tablets
6
Q
Classified as alternative medicine in the US EXCEPT
A
Allopathy
7
Q
Alternative medical practice that stresses the
use of extremely small dose of drugs
A
Homeopathic medicine
8
Q
Rate of disintegration for most commercial
tablets
A
sublingual -> uncoated -> coated
9
Q
Tablet coatings used to mask the bitter tastes
of drugs
A
film, sugar
10
Q
Diluent in tablet formulation EXCEPT
A
Magnesium stearate
11
Q
Functions of lubricant in tablet formulation EXCEPT
A
improve tablet wetting in the stomach
12
Q
Trademarked dosage form, enteric coated
A
Enseal
13
Q
Sweetener that is widely employed in
chewable tablet formulation
A
Mannitol
14
Q
Starch may be included in tablet formulation
A
Binder, disintegrant
15
Q
Commission E Monographs are related to
A
Herbs
16
Q
Specific drug is available both oral tablet and
liquid dosage forms
A
Liquid form absorbs faster
17
Q
General characteristics true for alkaloids EXCEPT
A
pKa less than 7
18
Q
Alkaloid powders exhibiting good water
solubility
A
Morphine HCl
19
Q
Form of basic drug haloperidol with good
water solubility
A
HCl, lactate
20
Q
Suitable as drug excipient EXCEPT
A
Benzocaine
21
Q
Included in the drug solution as chelating
agent
A
Edetate
22
Q
Ions effectively chelated
A
Lead
23
Q
Solubility of a substance may be expressed
in several ways. When a quantitative
statement of solubility is given in USP, it is
generally expressed as
A
mL of solvent to dissolve 1g of solute
24
Q
Although most drugs in pharmaceutical
dosage forms decompose following
first-order kinetics, exceptions are drugs
formulated in
A
Oral suspensions
25
Early sign of decomposing epinephrine
solution is the presence of
pink color
26
Process of grinding a substance to a very
fine powder
trituration
27
Term “impalpable” refers to a substance that
is
not perceptible to touch
28
Tartrazine may be included in drug products
coloring agent
29
Term “chiral” is related to a drug’s
stereoisomerism
30
Advantages of developing chiral forms of
drug
more direct action, economical
31
Different crystalline forms (polymorphs) of
the same drug exhibit different
melting point, solubility
32
Example of nonionic surfactant
sorbitan monopalmitate
33
Literature lists albuterol with two pKas of 9.3
and 10.3. Description most appropriate for
this drug
weak base
34
Patients following low sodium diets may
resort to the use of sodium-free salt
substitutes such as NoSalt. Major ingredient
in these products is
Potassium chloride
35
Potassium supplements are administered in EXCEPT
IV bolus
36
Statements true about fluorouracil EXCEPT
effective only when administered IV
37
Black box warning to a pharmacist
PI
38
Cautions found in drug product inserts in
order of least serious to most serious
Precaution, warning, CI
39
Comparison of individual amino acids
present in commercial amino acid injection
solution may be found in
Facts and comparison; Trissel's handbook of injectable drugs
40
Release of an ingredient from packaging components into the actual product is best described by the term
leaching
41
Gauge numbers used to size hypodermic
needles reflect the needle
external diameter, cannula
42
Designation “winged” needles is most closely
associated with which type of injection
IV
43
Insulin preparations are usually administered
by
SC
44
Needle most suited for the administration of
insulin solutions
25G 5/8"
45
Term “venoclysis” is closely associated with
IV Infusion
46
Designation “mini bottles” refers to
partially filled parenteral with 50 to 150mL volume
47
Term “piggyback” is most commonly
associated with
Intermittent therapy
48
Refer to parenteral nutrition
TPN/TNA
49
Approximate maximum volume of fluid that
should be administered daily by IV infusion to
stabilized patient
4L
50
Although isotonicity is desirable for almost all
parenterals, it is particularly critical to
SC
51
Suspension is suitable for EXCEPT
IV
52
Most appropriate medical order requiring an
intravenous bolus injection
IVP
53
Even distribution of drug into the blood after
an IV bolus injection can be expected
within 4 mins
54
Quantities of all ingredients present in
parenteral solutions must be specified on the
label EXCEPT for
isotonicity, and pH adjustors
55
Usual expiration dating should be placed on
a parenteral admixture prepared in hospital
pharmacy
24hr
56
Parenteral solutions that are isotonic with
human RBCs have an osmolality of
approximately how many mOsm/L
300
57
Injectables isotonic with human RBCs
D5W; D 2.5/0.45NS
58
Osmotic pressure of 1 0.1-mol dextrose
solution will be approximately __ times that
of 0.1-mol sodium chloride solution
0.5
59
Parenteral solution considered most closely
approximate the extracellular fluid of the
human body
LRS (Hartmann)
60
Injection routes limited to volumes of ≤ 1 mL
SC
61
Parenteral antibiotic least suitable for
surgical prophylaxis
Tetracycline
62
IM injection site suitable for a small child (<3
years of age)
Vastus lateralis
63
Parenteral routes of administration
considered suitable for heparin sodium
injection USP
Continuous IV infusion, sc
64
commonly employed for the administration of
insulin USP
Continuous IV infusion, im
65
Regular insulin
can be otc, short plasma half-life
66
Parenteral system “ADD-Vantage” is
vial attached to minibag of diluent
67
IVAC’s controlled-release infusion system (CRIS) is best described as
plastic disposable adaptor
68
Example of implantable catheter for the
administration of parenteral solution is
Port-A-Cath
69
Pharmacy Bulk Packages
for prep of sterile parenterals, no antimicrobial preservative
70
Parenteral container of potassium chloride concentrate must be packaged
black flip-off button
71
Usual maximum volume allowed as a
parenteral package for Bacteriostatic Water for Injection
30 mL
72
Benzyl alcohol is of specific danger in
Neonates
73
Vitamins possess antioxidant properties
Ascorbic acid
74
Parenteral antibiotic is most suitable in an aqueous solution
Gentamicin sulfate
75
Biologicals can be used to obtain either
active or passive immunity
Active: Toxoid, vaccine
Passive: anti-serm, antitoxin, immune serum
76
Vaccine used for active immunization against measles (rubeola)
Attenuvax
77
Route of administration of tuberculin USP
ID
78
Tuberculin syringes are
1mL w/ 0.05 accuracy
79
Vaccines for administration to children EXCEPT
Herpes
80
Immune serum globulin (gamma globulin) is usually administered by
IM
81
Pediatrix is a combination vaccine for EXCEPT
Hepa C
82
Vaccines NOT administered to pregnant
women
MMR
83
Preparation induces passive rather than
active immunity
Botox
84
Descriptions of toxoids EXCEPT
permanent immunity
85
DTP series of injections is intended for
administration to
Infants
86
Both Adacel and Boostix are examples of newer Tdap vaccines. Adcel differ from Boostix:
can be used for elders
87
Good candidates for pneumonia vaccine
Geriatrics, young adults
88
Usual storage condition specified for
biologicals
2-8
89
Viral infections EXCEPT
Typhoid fever
90
Techniques in the development of
“biotechnological drugs”
Gene splicing, monoclonal antibodies
91
Used to prepare “targeted drug delivery
systems”
Liposomes, nanoparticles
92
Most of the recently developed biotechnological drugs as formulated in this dosage form
parenteral
93
Diagnostic test incorporates monoclonal antibodies into the testing procedure
ovulation, pregnancy
94
Tablet which quickly dissolve in the mouth with the intent of being swallowed for GIT absorption
rapidly dissolving
95
Mechanism OraSolv compressed tablet
disintegrates
effervescence
96
Baxter intermates
elastomeric balloon
97
PCA devices
Px may be ambulatory, bolus dosing
98
Hospital pharmacist has reviewed several clinical papers concerning irritable bowel syndrome and is preparing a summary comparing the findings for publication.
Meta-analysis
99
Client in retail pharmacy asks the pharmacist where she might find a new lotion product that contains ECAMSULE. Section of the pharmacy should the pharmacist direct her
sun screen
100
Considered effective in the treatment of
accidental drug poisoning
activated charcoal, ipecac syrup
101
Most iron salts are administered orally, a commercially available parenteral product
DexFerrum
102
Iron sucrose injection
for iron deficiency anemia for pax undergoing hemodialysis
103
Chemical is effective and safe drug in
treatment of either diarrhea or constipation
polycarbophil
104
Simethicone is most likely to be included in this type of OTC product
antacid
105
Ingredient substituted in many OTC
antidiarrheal product as a replacement for the adsorbent attapulgite
bismuth subsalicylate
106
Suggested dosing regimen for loperamide 2 mg tablets for diarrhea
immediate 2 tab, one tab after loose stool
107
Common building block for liposomes
phospholipid
108
Liposomal dosage forms can be
administered
parenteral, oral, topical
109
Parenteral products have been formulated into liposomal dosage forms
amphotericin, daunorubicin
110
Doxorubicin HCl (Doxil) liposomal formula
stealth liposomes
111
OTC internal analgesics contains
magnesium salicylate
Doan's original
112
Dextromethorphan as cough suppressant EXCEPT
max adult dose 30mg
113
Disadvantages of calcium carbonate EXCEPT
Capacity for acid neutralization is poor
114
Contain calcium carbonate as active ingredient
Rolaids/Titralac chewable tab
115
Antacid product is a chemical combination of aluminum and magnesium hydroxides
Riopan
116
Drugs have label warnings against their use during pregnancy especially during the last trimester
Aspirin, Ibuprofen
117
Statement about bisacodyl EXCEPT
Tablets may be administered with milk to avoid GI irritation
118
OTC products containing bisacodyl as active ingredient EXCEPT
ExLax, Regular
119
Tablet dissolution EXCEPT
Increasing tab compression, increases dissolution
120
Product label indicates storage in a
refrigerator
Cold: 2-8
121
Patient requests a container of Abreva.
Section of pharmacy would this product be likely stocked
Cold sore
122
Aspertame is included in some drug products
sweetener
123
Term “circadian rhythm” refers
cycle approx. 24 hr
124
Antihypertensive drug product that is based on circadian rhythm
Covera-HS (Verapamil)
125
Properties desirable in a pharmaceutical suspension
Pseudoplastic flow, thixotrophy
126
Inhalation aerosol dosage forms
avoid first-pass effect, rapid onset
127
Internal analgesic products contain
ketoprofen
actron
128
Characteristic of first-degree burn
erythema, pain, no blister
129
Dextranomer (Debrisan by Johnson & Johnson) EXCEPT
Effective in healing both secreting nad nonsecreting wound
130
Effective local anesthetics present in OTC burn remedies
benzocaine; lidocaine
131
For effectiveness as local anesthetic, the
level of benzocaine in a topical preparation should
at least 5%
132
“French” scale commonly used for denoting diameters of
Urinary catheter & enteral feeding tube
133
Basal thermometer
estimate ovulation
134
Rectal clinical thermometers differ from oral thermometers in
bulb shape
135
Allergic reactions to insect bites and stings EXCEPT
Toxicity of venom main cause of death
136
Emergency insect sting and bite kits contains EXCEPT
Torniquet
137
Ointment contains 2,000 units of enzyme per gram. Drug’s half-life if the decomposition rate is calculated to be 50 units per month
20 months
138
Manufacturer’s decides to market the above enzyme
ointment at higher strength of 4,000 units per gram.
Approximate expiration date if standard of not less than
90% labeled claim is established
8 months
139
Pamabrom is present in certain OTC
products as
Diuretic
140
Ingredient has been recognized by FDA for the removal of ear cerumen
Carbamide peroxide
141
Improve the absorption of drug into the skin EXCEPT
ointment base with excellent solubility
142
Melatonin is available in some products
sleep aid
143
Most appropriate procedure for using
Melatonin to prevent jet lag
take after reaching diff time zone
144
Most commercial vaginal suppositories
PEG
145
Diluent usually used for compressed vaginal tablet formulation
Lactose
146
Rectal drug administration except
predictable release and absorption
147
Vaginal suppository with contraceptive property
Semicid
148
Carbomers included in topical products
thickening agent
149
Colligative properties are useful in
determining
tonicity
150
Colligative properties of solution
Related to total number of solute
