Parkinsons

Question 1

What does it do?

Answer 1

Carbidopa

Inhibitor of AAD

Question 2

What the give away that makes it an inhibitor

Answer 2

Talcapone

COMT I

Nitro group with catechol system

Question 3

Answer 3

Propargel group

MAO I irreversible

Question 4

Its a potent?

Answer 4

Dopamine agonist

Emetic

Dopamine in locked conformation

Previagra

Apomorphine

Question 5

In parkinsons there are two receptors in the striatum?

Which one is decreased which one is increased?

Answer 5

D1-Excitatory decreased

D2- Inhibitory increased

Question 6

Direct pathway?

Answer 6

D1

Question 7

Indirect pathway

Answer 7

D2

Question 8

tyrosine, tyrosine epoxide

DA semiquinone and DA quinone are all?

Answer 8

Compounds indicated in neuronal cell death

Question 9

D1, 5 receptor increases levels of?

Answer 9

cAMP

Question 10

D2-4 receptor decrease levels of?

Answer 10

cAMP

Question 11

Tyrosine is converted into _____ then in the presence of _____ is coverted to?

Answer 11

L-dopa (BBB+)

MAO

Dopamine (BBB-)

Question 12

How does L-dopa cross the BBB?

Answer 12

It is actively transported and the presence of both the Amino and Carboxylic acid group forms a zwitter ion and cause less unionizable things

Question 13

MPPP —-> ____ —- MPDP—>MPP

Causing?

Answer 13

Nigrostriatal cell death

Question 14

Apomorphine locks dopamine in what conformation which is?

Answer 14

Locked into trans alpha rotamer which is favorable to the receptor

Question 15

L-dopa is used in combination with?

Which is?

Answer 15

Carbidopa

Aromatic AA Decarboxylase Inhibitor

and COMPT

Question 16

Adverse effects of combination L-dopa and carbidopa therapy?

Answer 16

Dose related dyskinesia (Impairement of voluntary movement)

Pathological gambling

CNS effects simialr to Schizo

Question 17

Tolcapone and Entacapone are?

Answer 17

Compt I

Question 18

Entacapone has a?

Answer 18

Short T1/2 and should be taken with every dose of L-dopa

Question 19

Amantadine is a?

Answer 19

DA releaser

ClogP = 2.0

Question 20

MAO-B inhibitors have a? bond

Answer 20

Ctriple bond CH

Irreversible inhibitor of MAO-B

Question 21

Rasagiline has?

Answer 21

Fewer adverse effects compared to L-deprenyl (Selegiline)

Question 22

Sofinamide is a?

Answer 22

Reersible and selective MAO-B I

Question 23

DA receptor agonists

they all have?

Answer 23

Can lower required dose of l-dopa

Locked confomer of DA

S-enatiomer has post synaptic D2 antagonism

Question 24

Anticholinergics do what for parkinsons?

Answer 24

Help reduce drooling and tremors

Question 25

Dopa Scan is?

Answer 25

Longer acting

tropone ring