Parkinsons Flashcards
What does it do?
Carbidopa
Inhibitor of AAD
What the give away that makes it an inhibitor
Talcapone
COMT I
Nitro group with catechol system
Propargel group
MAO I irreversible
Its a potent?
Dopamine agonist
Emetic
Dopamine in locked conformation
Previagra
Apomorphine
In parkinsons there are two receptors in the striatum?
Which one is decreased which one is increased?
D1-Excitatory decreased
D2- Inhibitory increased
Direct pathway?
D1
Indirect pathway
D2
tyrosine, tyrosine epoxide
DA semiquinone and DA quinone are all?
Compounds indicated in neuronal cell death
D1, 5 receptor increases levels of?
cAMP
D2-4 receptor decrease levels of?
cAMP
Tyrosine is converted into _____ then in the presence of _____ is coverted to?
L-dopa (BBB+)
MAO
Dopamine (BBB-)
How does L-dopa cross the BBB?
It is actively transported and the presence of both the Amino and Carboxylic acid group forms a zwitter ion and cause less unionizable things
MPPP —-> ____ —- MPDP—>MPP
Causing?
Nigrostriatal cell death
Apomorphine locks dopamine in what conformation which is?
Locked into trans alpha rotamer which is favorable to the receptor
L-dopa is used in combination with?
Which is?
Carbidopa
Aromatic AA Decarboxylase Inhibitor
and COMPT
Adverse effects of combination L-dopa and carbidopa therapy?
Dose related dyskinesia (Impairement of voluntary movement)
Pathological gambling
CNS effects simialr to Schizo
Tolcapone and Entacapone are?
Compt I
Entacapone has a?
Short T1/2 and should be taken with every dose of L-dopa
Amantadine is a?
DA releaser
ClogP = 2.0
MAO-B inhibitors have a? bond
Ctriple bond CH
Irreversible inhibitor of MAO-B
Rasagiline has?
Fewer adverse effects compared to L-deprenyl (Selegiline)
Sofinamide is a?
Reersible and selective MAO-B I
DA receptor agonists
they all have?
Can lower required dose of l-dopa
Locked confomer of DA
S-enatiomer has post synaptic D2 antagonism
Anticholinergics do what for parkinsons?
Help reduce drooling and tremors
Dopa Scan is?
Longer acting
tropone ring
