Parkinson's pharmacology Flashcards
Which Parkinson’s medication - levodopa, dopamine agonist or MAO inhibitors - improve motor symptoms the most?
Levodopa
Which Parkinson’s medication - levodopa, dopamine agonist or MAO inhibitors - improve symptoms with activities of daily living the most?
Levodopa
Which Parkinson’s medication - levodopa, dopamine agonist or MAO inhibitors - is associated with the most motor side effects?
Levodopa
Dopamine agonists and MAO inhibitors are associated with more specified adverse effects - name 2 of these
- Excessive sleepiness
- Impulse control disorder (esp. dopamine agonist)
- Hallucinations
What type of dopamine agonist - ergot derived or non-ergot derived is used in PD?
Non-ergot derived
In the early stages of PD, if motor symptoms are affecting the patients quality of life, what drug is given first line?
Levodopa
In the early stages of PD, if motor symptoms aren’t affecting the patients quality of life, what drug can be given 1st line?
- Levodopa
- Dopamine agonist
- MAO inhibitor
For patients that have developed dyskinesia or motor fluctuations despite optimal levodopa treatment, name a drug that can be used in adjunct?
- Dopamine agonist
- MAO inhibitor
- COMT inhibitor
Which medication, MAO inhibitor, COMT inhibitor or dopamine agonist is most associated with hallucinations?
Dopamine agonist
Which medication, MAO inhibitor, COMT inhibitor or dopamine agonist is most associated with more of an off time reduction than the other 2?
Dopamine agonist
Out of a MAO inhibitor, COMT inhibitor or dopamine agonist, which is associated with fewer adverse effects, which is associated with intermediate adverse effects and which is associated with more adverse effects?
- Few = MAO inhibitor
- Intermediate = dopamine agonist
- More = COMT inhibitor
Withdrawing anti-parkinson drugs abruptly shouldn’t be done due to the risk of what 2 things?
- Neuroleptic malignant syndrome (high fever, unstable BP, sweating)
- Acute akinesia
