Parkinson's Disease

Question 1

Are Parkinson’s symptoms symmetrical or asymmetrical

Answer 1

asymmetrical

Question 2

Triad of motor symptoms for Parkinson’s

Answer 2

1. Bradykinesia
2. Rigidity
3. Pill rolling resting tremor

Question 3

Which type of dementia is most strongly associated with Parkinson’s

Answer 3

LBD

Question 4

Which class of Parkinson’s drugs should be given first line to older patients

Answer 4

L-DOPA (most effective)

Question 5

Which class of Parkinson’s drugs should be given first line to younger patients

Answer 5

Dopamine agonists (delays onset of motor complications)

Question 6

Which class of Parkinson’s drugs results in the most motor complications

Answer 6

L-DOPA

Question 7

Which 3 Parkinson’s drugs are considered first line

Answer 7

1. L-DOPA
2. Dopamine agonists
3. MAO-B

Question 8

Which 4 types of drugs should one avoid prescribing for Parkinson’s patients

Answer 8

1. Antipsychotics
2. Antiemetics
3. Sodium valproate
4. CCBs

Question 9

What premotor symptoms might one see before the development of Parkinson’s Disease

Answer 9

• impaired olfaction
• REM behaviour disorder
• Depression
• Constipation (dysautonomia)

Question 10

What are the general classes of first line treatments for Parkinson’s

Answer 10

MAO-B inhibitors
Levodopa
Dopamine agonists

don’t give ergot-derived dopamine agonists unless

Question 11

Mechanism of action of Rasagiline

Answer 11

MAO-B inhibitor

Question 12

Mechanism of action of Ropinirole

Answer 12

Non-ergoline dopamine agonist

Question 13

Mechanism of action of Rotigotine

Answer 13

Non-ergoline dopamine agonist

Question 14

Difference in when you would diagnose someone with Parkinson’s disease dementia vs Lewy Body dementia

Answer 14

New-onset Parkinson’s symptoms + dementia would suggest LBD

Established Parkinson’s, more likely to be Parkinson’s disease dementia

Question 15

Another name for Willis Ekbom disease

Answer 15

Restless legs syndrome