Parkinson's Disease Flashcards
most common symptom in parkinsons
resting tremor
surgical procedure of choice in controlling parkinsonian symptoms
deep brain stimulation
What pathway is degenerated in parkinson’s
nigrostriatal pathway, which connects the substantia nigra to the corpus striatum
MOA of amantadine
- potentiates release of endogenous dopamine
- mild anticholinergic activity
- inhibits dopamine reuptake
- blocks glutamate receptors
most common parkinson-plus syndrome
progressive supranuclear palsy
parkinsonian features with dystonia (anterocollis)
striatonigral degeneration
2 types of multiple system atrophy
parkinsonian type and cerebellar type
what part of the brain is affected in parkinson’s
substantia nigra and locus coeruleus in the basal ganglia
parkinsonian features with ataxia and dysarthria
olivopontocerebellar atrophy
examples of anticholinergics
- trihexyphenidyl
- benztropine
- procyclidine
- orphenadrine
parkinsonian features with dysautonomia (autonomic dysfunction)
shy-drager syndrome
what are some examples of ergot derivatives
bromocriptine and pergolide
microscopically, what is found in damaged cells in the brain in parkinson’s
lewy bodies, which are intracytoplasmic eosinophilic inclusion bodies
what is MOA of carbidopa
dopa-decarboxylase inhibitor that prevents metabolism of L-dopa
what is MOA of ergot derivatives
dopamine agonist agents that directly stimulate dopamine receptors
