Huntington's Disease

Question 1

what can be seen on CT/MRI of brain in huntington’s

Answer 1

atrophy of caudate nucleus

Question 2

classic triad of huntington’s

Answer 2

1. chorea
2. personality disorder/dementia
3. family history

Question 3

what is chorea due to

Answer 3

increased sensitivity to striatal dopamine receptors

Question 4

3 dopamine receptor blockers used in huntingtons

Answer 4

1. haloperidol
2. fluphenazine
3. perphenazine

Question 5

westphal variant of huntington’s disease

Answer 5

huntington’s + hypokinesia and rigidity (similar to parkinson’s)

Question 6

most effective agent in suppressing the movement disorder in huntington’s

Answer 6

Haloperidol

Question 7

MCC of death in huntington’s

Answer 7

aspiration pneumonia

Question 8

Genetics of huntington’s disease

Answer 8

autosomal dominant, trinucleotide CAG repeat