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CNS > Parkinson's > Flashcards

Parkinson's Flashcards

1
Q

Progressive neurodegenerative disease

A

Death of dopamine of S.N

- motor/non-symptoms

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2
Q

Motor symptoms

A 
H
B
R
R
P
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3
Q

COMT inhibitors

A

Entacapone

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4
Q

Dopamine precursors

A

Co-beneldopa/co-careldopa

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5
Q

Dopamine receptor agonist

A

Amantadine, apomorphine, pramipexole, ropinirole

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6
Q

MAOI (B)

A

Rasagiline, selegiline

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7
Q

Levodopa + carbidopa/benserazide

A

Motor symptoms which decrease QoL

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8
Q

Levodopa or non-ergot derived dopamine receptor agonists (prami/rop) or MAOI (B)

A

Motor symptoms which does not affect QoL

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9
Q

Daytime sleepiness and sudden onset of sleep

A

Modafinil

- inform DVLA

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10
Q

Nocturnal akinesia

A

Levo/oral dopamine receptor agonist (1st line) or rotigotine (2nd line)

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11
Q

Postural hypotension

A

Midodrine (1st line)

Fludro (alt)

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12
Q

Psychotic symptoms

A

Quet

Clozapine = alt

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13
Q

Rapid eye movement (sleep)

A

Clonazepam or melatonin

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14
Q

Drooling saliva

A

Only considered if non-drug approach

  • glycopyrronium
  • botu tox type A
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15
Q

Parkinson’s dementia

A

CI except rivastigimine

- memantine if CI is C/I

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16
Q

Advanced PD

A

Apomorphine hydrochloride inj/infusions

Domperidone (counter N+V)

17
Q

Impulse control disorders

A

Levo, amo, prami, ropin, roti

18
Q

Fibrotic reactions - SOB, cough, chest pain, ab pain

A

Bromocrip, cab, pergolide

CNS (9 decks)

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