Parathyroid Hormone

Question 1

PTH1 receptor is activated by

Answer 1

Precursor derived peptides

Question 2

PTH2 receptor is activated by

Answer 2

Precursor derived peptide TIP39

Question 3

Human recombinant parathyroid hormone is indicated for whom?

Answer 3

For the treatment of osteoporosis in postmenopausal women at high risk of osteoporotic fractures

Question 4

What is the MOC of human recombinant parathyroid hormone?

Answer 4

Mediated through binding to at least two distinct high affinity cell surface receptors specific for the N terminal and C terminal regions of the molecule

Question 5

The N terminal portion of the HRPH is primarily responsible for what?

Answer 5

Bone building effects

Question 6

The C terminal portion of the RHPH is responsible for?

Answer 6

Antiresorptive activity and is necessary for normal regulation of N terminal fragment activity

Question 7

PTHrp is critical for what?

Answer 7

Promoting new bone formation

Question 8

What is abalopararide?

Answer 8

Analogue of PTHrp

Question 9

What is the indication for abaloparatide?

Answer 9

Treatment of postmenopausal osteoporosis to reduce vertebal and/or non-vertebral fractures

Question 10

What is the mechanism of action of abaloparatide?

Answer 10

Acts as an agonist of PTH type 1 receptor and activates both G protein mediated cAMP and Beta-arrestin mediated ERK-1/2 signaling pathways with similar potency

Question 11

Abaloparatide binds to receptor coupled G protein of PTH1R with greater

Answer 11

Selectivity

Question 12

What are the indications for cincacalcet?

Answer 12

Secondary hyperparathyroidism in patients with chronic kidney disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma

Question 13

What is the MOC of cinacalcet?

Answer 13

Lowers calcium levels by increasing the sensitivity of the calcium sensors which leads to less PTH secretion