Parathyroid Disoders - Exam 3 Flashcards

1
Q

Where are the parathyroid glands located? How many? Describe their appearance.

A

posterior thyroid gland

4 glands located on the posterior thyroid gland

Size -grain of rice to pea-sized
Shape - smooth surface, oval or bean-shaped
Normally not visible or palpable on neck exam

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2
Q

Parathyroid Hormone (PTH), which plays a key role in regulating _____ level. ____: synthesize and release PTH. ______ are less abundant, larger, acidophilic, nonfunctional

A

extracellular calcium

Principal (chief) cells

Oxyphil cells

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3
Q

Amounts of _____ and ____ increases with age

A

adipocyte deposits

oxyphil cells

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4
Q

Describe the textures of the thyroid and parathyroid glands

A

thryoid is bumpy

parathyroid is smooth

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5
Q

What is the net effect of PTH? ______ in the serum interacts with _____ on the surface of cells in the parathyroid glands and kidney

A

increase serum calcium

Ionized Calcium (aka free calcium, NOT bound to albumin)

calcium-sensing receptors (CaSR)

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6
Q

What do high calcium levels stimulate? What about low calcium levels?

A

stimulates CaSR receptors → PTH suppression

CaSR receptors are not stimulated → PTH release

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7
Q

What is PTH’s response to low calcium? minutes? hours? days?

A

minutes: release of preformed PTH

hours: PTH mRNA expression → increased PTH synthesis

days: parathyroid cell replication → increased parathyroid gland mass

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8
Q

What are the 4 functions of calcium?

A

-maintain skeletal strength

-regulates contraction of muscle

-cellular signaling (especially neurons)

-secretion of hormones and enzymes

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9
Q

Where are the 3 areas that calcium is stored?

A

1: bone as hydroxyapatite

#2: intracellular fluid
#3: Extracellular fluid

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10
Q

Bone: majority (99%) of the calcium in bone is stored as _____

A

hydroxyapatite

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11
Q

What is the job of calcium that is stored in the intracellular fluid?

A

Intracellularsignaling (second messengers), enzyme activation, muscle contraction

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12
Q

What is important to note about the calcium that is stored in extracellular fluid?

A

50% of the calcium is bound to proteins and only has minimal fluctuation

50% is unbound and fluctuates freely

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13
Q

______ is serum calcium that is not bound to proteins. How is serum calcium balance maintained?

A

Ionized calcium

by release of calcium from intracellular storage or influx from extracellular fluid

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14
Q

What 3 organs are responsible for maintaining the narrow balance of EXTRAcellular calcium and phosphorus? What are the responsibilities of each?

A

intestines: absorb dietary Ca

kidneys: reabsorb or excrete Ca as needed

skeletal system: reservoir for Ca, releases and reserving as needed

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15
Q

What is the function of phosphorus?

A

Helps form several major body components: skeleton (its part of hydroxyapatite), cell membranes, DNA/RNA and ATP

balance of several vitamins and minerals

pH regulation and enzyme activation

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16
Q

Most phosphorus in the body is as the ______. Name 3 places phosphorus is stored?

A

phosphate ion, PO4

Bone - majority (85%) in bone as hydroxyapatite

Intracellular/Soft Tissues - (14%) of overall body phosphorus. Phosphate ion, several parts of cellular structures and enzymes.

Extracellular Fluid - Blood, extracellular matrix
1% of overall body phosphorus, mainly as the ion PO4

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17
Q

_____ enhances the intestines ability to absorb calcium and phosphorus

A

vitamin D

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18
Q

In a normal healthy person, how are calcium and phosphorus related? What 3 major hormones maintain this balance?

A

inverse relationship, when calcium increases phosphorus decreases

PTH

Vit D (Calcitriol)

Calcitonin

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19
Q

What are the effects of PTH on bone? on kidney?

A

Bone:
Stimulates release of Ca2+
Stimulates release of PO4-

Kidney:
Increased Ca2+ reabsorption
Increased PO4- excretion
Stimulates production of calcitriol (1,25 Vitamin D)

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20
Q

How does PTH effect calcitriol?

A

Converted from inactive 25-OH Vitamin D by kidneys under the influence of PTH to its metabolically active form

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21
Q

What are the effects of calcitriol on the intestines?

A

Increased calcium absorption
Increased phosphorus absorption

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22
Q

What are the effects of calcitriol on bone?

A

Enhances effects of PTH on bone to promote more calcium release

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23
Q

Where does calcitonin originate? When is it released? What is the effect of calcitonin on the body?

A

calcitonin-secreting cells (C cells) in the thyroid

Calcitonin is released by the thyroid when C-cells become overstimulated by elevated calcium levels

Works in opposition to PTH
Suppresses renal reabsorption of Ca2+ → increased Ca2+ excretion
Inhibits osteoclasts in bone → decreased release and increased storage of Ca2+

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24
Q

What does the total serum calcium measure? What is normal? Which is the metabolically active form?

A

protein bound Ca plus free Ca

8.5-10.5

40-50% is protein bound to albumin

ionized calcium is free and considered metabolically active 4.4-5.4

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25
What does high serum calcium mean? low serum calcium?
High - bone breakdown (elevated PTH, cancer), supplementation, kidney dz, meds Low - low PTH, low vitamin D, kidney disease
26
____ and ___ could cause a serum calcium to look falsely elevated. _____ could cause it to look falsely low.
hemoconcentration and elevated serum proteins low serum proteins
27
Abnormal _____ requires a corrected calcium level! Under what conditions is the corrected calcium calculation NOT accurate?
albumin serum calcium + [0.8 x (4.0 - albumin)] acid/base disorders Acidosis - decreased calcium binding to albumin Alkalosis - increased calcium binding to albumin
28
_____ is the current standard for dx of hyperparathyroidism. Is it accurate?
Serum Parathyroid Hormone (PTH) very sensitive and specific test
29
What is the process of Vit D becoming active in the body? aka what forms of Vit D and what organs are required?
The LIVER converts D2/D3 (which is normally the form pts take PO) to 25-OH Vit D, which is metabolically inactive The KIDNEY then takes 25-OH Vit D and converts it to active 1,25 Vit D (calcitriol)
30
_____ form of vit D is the result when you order a "Vit D level"
Serum 25-hydroxy vitamin D
31
**Which form of Vit D supplement is synthesized in skin, found in animal-derived diet food?
D3 (Cholecalciferol)
32
**Which form of Vit D supplement is derived from plant sources?
D2 (Ergocalciferol)
33
______ Metabolically active form of vitamin D. What is the normal range? What does a high level indicate? low level? _____ is a result that could make it look falsely evelated
1,25 Vitamin D (Calcitriol) 20-76 pg/mL High: excess supplementation, hyperparathyroidism, extrarenal production (granulomatous disease, lymphoma) low: CKD, severe vitamin D deficiency, heritable diseases, tumor-induced osteomalacia, HIV protease inhibitors
34
What does a high serum phosphorus indicate? Low indicate? ______ are reasons why it could be falsely elevated?
High: hypoparathyroidism, kidney disease, supplementation, acidosis, cell lysis, several other conditions Low: Low - hyperparathyroidism, malabsorption or poor diet, certain medications, low vitamin D, several other conditions high levels of lipids, protein, or bilirubin
35
What is important to note about a serum phosphorus?
can bounce all over the place within the normal range highest: in late morning in May/June Lowest: in the evening in the winter Also varies with food, antacids, renal function, menopause, pregnancy, bedrest
36
______ naturally found in various cells; especially active in tooth eruption and mammary gland development. Pathologically secreted by cancer cells and attaches to _____ receptors. What is the effect? What does a high test indicate?
Parathyroid Hormone Related Protein (PTHrP) PTH Results in a PTH-like effect on the bone and kidney High - Humoral Hypercalcemia of Malignancy
37
90% of hypercalcemia results from _____ and ______. What are the other potential causes of hypercalcemia?
hyperparathyroidism due to adenoma and lithium malignancy vit D related aka too much vit D
38
What are the parathyroid related causes of hypercalcemia?
**Adenoma- MC-excess secretion of PTH due to increased parathyroid mass Lithium: decreases parathyroid gland sensitivity to calcium
39
What cause of hypercalcemia decreases parathyroid gland sensitivity to calcium?
lithium
40
What cause of hypercalcemia is due to osteolysis, release of PTH-related protein (PTHrP)?
malignancy
41
What cause of hypercalcemia is due to increased GI calcium absorption and bone calcium release?
increases in Vit D aka they are supplementing too much
42
What are some causes of high bone turnover that could lead to hypercalcemia? What is the major one?
hyperthyroid: thyroid hormone stimulated bone resorption immobilization **thiazides: decreases urinary calcium excretion in addition to bone resorption
43
______ decreases urinary calcium excretion in addition to bone resorption. What does it lead to?
thiazides hypercalcemia
44
What are some causes of renal failure that can lead to hypercalcemia? What is the major one?
Tertiary hyperparathyroidism **Milk-alkali syndrome
45
_____ hyperplasia of the parathyroid glands from prolonged CKD persisting in elevated PTH (even if calcium normalizes with CKD treatment). What can it lead to?
Tertiary hyperparathyroidism hypercalcemia
46
_____ Calcium carbonate supplementation to treat osteoporosis or dyspepsia - combination of hypercalcemia, metabolic alkalosis, renal impairment. What can it lead to?
**Milk-alkali syndrome: rates are increasing hypercalcemia
47
Bone pain kidney stones constipation stomach ulcers fatigue confusion AMS Shorted QT interval Diminished reflexes Bradycardia Hypertension What am I? What is a highlighted symptom?
Hypercalcemia **Shorted QT interval
48
In calcium related disorder the _______ the more prominent the symptoms
more rapid the elevation the more prominent the symptoms
49
What is the tx for hypercalcemia?
identify and treat the underlying cause rehydration: IV NS 500-1000 mL/h x 2-4 hrs, as tolerated Loop Diuretics: IV furosemide Corticosteroids Bisphophonates and/or Calcitonin
50
Tx of hypercalcemia, what do we need to monitor for when using loop diuretics?
Monitor for SE of hypokalemia, hypomagnesemia Risk of paradoxical increase in Ca2+ due to bone resorption
51
Tx of hypercalcemia, why are we using corticosteroids?
Decreases conversion of inactive to active vitamin D Especially beneficial when excess calcitriol is a contributing factor
52
Tx of hypercalcemia, why are we using Bisphosphonates, Calcitonin?
Decreases release of calcium from bone Especially beneficial in chronic cases where PTH is elevated
53
What are the two MC causes of hypocalcemia?
MC causes of hypocalcemia are impaired production of PTH and/or vitamin D
54
What are some causes of hypocalcemia with a low PTH? Is this considered primary or secondary hypoparathyroidism? What does this cause?
Parathyroid agenesis Parathyroid destruction: surgical, radiation, cancer, autoimmune Reduced parathyroid function: Low magnesium - required for PTH production and release primary hypocalcemia
55
What are some causes of hypocalcemia with a high PTH? Is this considered primary or secondary hypoparathyroidism? What does this cause?
**Vitamin D deficiency: Nutritional, poor UV exposure, **kidney disease**, liver disease **tissue injury PTH resistance (PTH receptor mutations) Malabsorption Medications: calcium chelators, bisphosphonates secondary: aka the parathyroid gland is fine, something else is the source of the error hypocalcemia
56
anxiety irritability seizures hyperactive reflexes cramps Chvostek sign Trousseau sign dysrhythmias prolonged QT interval What am I?
hypocalcemia
57
_____ Facial twitching, especially perioral, induced by gently tapping the ipsilateral facial nerve just anterior to the ear
Chvostek's sign
58
____ Carpal spasm induced by inflating BP cuff around the arm (must achieve pressure 20 mmHg above obliteration point for 3-5 min)
Trousseau's sign
59
What labs would you want to evaluate on pt with hypocalcemia?
Parathyroid hormone (PTH) Vitamin D (both 25-OH Vitamin D and 1,25 Vitamin D/calcitriol) Albumin Creatinine Calcium (correct if necessary) Phosphorus Magnesium
60
What is the treatment for hypocalcemia? Severe?
identify and treat underlying cause Calcium replacement (give Vit D if needed) ______________ IV Calcium - 10% calcium gluconate 10-30 mL IV over 10-20 min IV Magnesium if also low Vit D if needed
61
**What can IV calcium cause that you need to be mindful of?
IV calcium can cause vasoconstriction and possible ischemia
62
_____ excessive PTH secretion leading to hypercalcemia, hypophosphatemia. It is the MC cause of ______. What is the MC pt demographic?
Primary Hyperparathyroidism hypercalcemia black then white women over 50-65 years old
63
Primary Hyperparathyroidism is usually caused by a ______
parathyroid adenoma
64
often asymptomatic discovered incidentally secondary to hypercalcemia: Bone pain, constipation, fatigue, altered mental status, bradycardia, kidney stones/nephrocalcinosis What am I? Can you usually feel a mass?
Primary Hyperparathyroidism Parathyroid adenoma is not typically palpable on exam unless it is a carcinoma then you can in 52% of patients
65
What will the calcium and PTH lab values look like in primary hyperparathyroidism? What will labs look like if carcinoma is present?
corrected or ionized calcium: will be elevated PTH: will be elevated ____ corrected or ionized calcium: If carcinoma present - levels often ≥ 14.0 mg/dL **PTH: If carcinoma present - PTH often >5x ULN
66
What is the way to confirm your dx of primary hyperparathroidism?
elevated PTH in the presence of elevated ionized/corrected calcium
67
What do you do if PTH is normal/minimally high compared to Ca?
check 24 hr urine Ca check for familial hypocalciuric hypercalcemia
68
**What is familial hypocalciuric hypercalcemia? What condition is it associated with?
are autosomal dominant d/o causing decreased function of calcium-sensing receptors on parathyroid and renal cells , so that higher than normal serum calcium concentrations are needed to suppress PTH release primary hyperparathyroidism
69
If the 24 hour urine calcium is above _____ is (includes/excludes) FHH. If it is less than _____, what does it tell you? What medications must be help prior to testing?
200-300 excludes: so probably primary hyperparathryoidism less than 200: FHH or primary hyperparathyroidism with vit D deficiency Must stop loop and thiazide diuretics prior to testing
70
_____ helps differentiate primary from secondary hyperparathyroidism. What does the results indicate?
Serum phosphorus Normal to Low (< 2.5 mg/dL) - primary hyperparathyroidism High (>4.5 mg/dL) - secondary hyperparathyroidism
71
What will Serum 25-OH Vitamin D and eGFR look like in primary hyperparathyroidism?
Serum 25-OH Vitamin D - may be low in hyperparathyrodism due to excessive conversion of 25-OH vitamin D to 1,25 vitamin D (calcitriol) eGRF: just checks the status of the kidneys aka looking for renal dysfunction
72
Is imaging needed to dx primary hyperparathyroidism?
NOT needed to dx only needed if you are thinking sx
73
_____ is the most used imaging for soft tissues in the neck. When is Nuclear Medicine Parathyroid Scan used? When are CT-4D scans used?
Neck US to check function of Hyperfunctioning parathyroid glands light up brighter than normal tissue Uses CT imaging to capture rapid uptake and washout of parathyroid adenomas Mainly used if US and parathyroid scan are indeterminate or if concern for ectopic parathyroid tissue (adenomas, carcinomas) aka measured over time and looking for metabolic activity
74
What is the tx for asymptomatic primary hyperparathryoidism?
Geared at keeping bones healthy and minimizing symptoms Adequate hydration - 6-8 glasses of water/day Encourage physical activity: reduces bone resorption Avoid medications that aggravate hypercalcemia: **Thiazides**, lithium, high doses of vitamin A Moderate intake of calcium (1000 mg/d) and vitamin D (400-800 IU/d) routine monitoring of labs: serum calcium, 25-OH Vit D, PTH renal function labs 24-hr urine for calcium DEXA scans
75
What medications should a pt with primary hyperparathyroidism avoid?
**Thiazides**, lithium, high doses of vitamin A
76
What is the DEFINITIVE treatment for asymptomatic primary hyperparathyroidism? What are the requirements? What happens if they are symptomatic?
surgery only have to meet ONE criteria: Kidney stones or nephrocalcinosis Bone disease (osteopenia, osteporosis, pathologic fracture) Persistent urinary calcium >400 mg/dL Serum calcium >1 mg/dL above ULN Age <50 years old same criteria PLUS symptomatic or anyone who wants a cure and is healthy enough for surgery
77
What is the management for symptomatic nonsurgical primary hyperpararthyroidism whose bone density is WNL? What are the SE? What does it NOT do?
cinacalcet (Sensipar) nausea, arthralgia, diarrhea, myalgia, paresthesia Does not improve bone density or reduce calciuria
78
_____ binds to CaSRs in parathyroids, thereby decreasing PTH secretion. What lab do you need to monitor? and when?
cinacalcet (Sensipar) aka its calcium receptor blocker Recheck serum calcium one week after initiating!
79
What is the management for symptomatic nonsurgical primary hyperpararthyroidism whose also has osteoporosis? What does it NOT do?
Bisphosphonates: oral: alendronate (Fosamax), ibandronate (Boniva) IV: pamidronate (Aredia), zoledronic acid (Reclast) _____ Oral versions do not significantly impact hypercalcemia or hypercalciuria! IV: Can temporarily treat hypercalcemia
80
_____ bind to hydroxyapatite and, when resorbed by osteoclasts, impair ability of osteoclasts to continue to resorb bone Also decrease numbers of active osteoclasts by inhibiting osteoclast progenitor development and encouraging osteoclast apoptosis. Oral version, what is the pt education? When is the IV version used?
Bisphosphonates oral: Patient must be able to remain upright for 30 minutes after ingestion IV: Can temporarily treat hypercalcemia May be used to help prepare patients with severe hypercalcemia for surgery
81
Which management for primary hyperparathyroidism can cause a slight reduction in serum calcium specifically when given to postmenopausal women? Is it first line?
Estrogen Replacement: aka protective effect on CA in the bones NOT first line
82
_____ selective estrogen receptor modulator (SERM). Estrogen agonist in the bone to decrease bone resorption. Estrogen antagonist in the uterus and breast to reduce cancer risk. Is it a first line tx? What condition?
Raloxifene (Evista) NOT first line to treat primary hyperparathyroidism
83
What are complications of primary hyperparathyroidism?
Weakened bones → osteopenia, osteoporosis, pathologic fractures (treat with Prolia, DEXA scan q 2 years, vertebrae at highest risk of fracture) Vit D deficiency renals effects: nephrolithiasis, nephrocalcinosis, CKD
84
____ excessive PTH secretion leading to hypercalcemia, hypophosphatemia that is caused by an underlying chronic abnormal stimulus or disease. What is the MC etiology?
Secondary Hyperparathyroidism chronic kidney disease
85
Why is chronic kidney disease the MC cause of secondary hyperparathyroidism? What is the 2nd most common cause?
Poor renal reabsorption of calcium (hypocalcemia) Inhibited excretion of phosphate (hyperphosphatemia) Inadequate renal conversion of 25-OH Vit D to 1,25 Vit D ______ Vit D deficiency
86
What is the MC pt demographic for secondary hyperparathyroidism?
Black/Hispanic elderly women
87
HTN edema abnormal laboratory values: Low Vit D LESS likely to have classic s/s of hyperparathyroidism s/s of hypocalcemia: hyper- reflexive What am I? What will BUN/Creatine/eGFR show? PTH/Calcium/Phosphorus/1,25 Vit D?
secondary hyperparathyroidism BUN/Cr: will be elevated eGFR: will be decreased PTH - elevated Calcium - low to normal Phosphorus - high in CKD; low in vitamin D deficiency 1,25 Vitamin D - low in CKD and vitamin D deficiency
88
When would you order imaging on a pt with secondary hyperparathyroidism?
to look for complications aka bone pain to look for pathologic fractures
89
What is the management of secondary hyperparathyroidism?
refer to nephro if CKD is present Vit D supplementation specifically 1,25 Vit D (Calcitrol aka the one that you do NOT need good kidneys for because it is already active)
90
What is the MC cause of hypoparathyroidism? What are other causes?
typically involves some damage to the parathyroids usually some time of neck sx autoimmune, radiation, infection, infiltration of cancer etc
90
______ group of disorders characterized by kidney and/or bone resistance to PTH. What will calcium, phosphate and PTH lab values look like? What is the treatment?
Pseudohypoparathyroidism decreased calcium increased phosphate increased PTH calcium and vitamin D therapy to maintain normal serum calcium levels akak kidney/bones are not responding to PTH
91
You can see ____ associated with hemochromatosis, Wilson’s disease and/or Riedel thyroiditis
Hypoparathyroidism
92
functionally hypoparathyroidism is associated with _____ levels. What will severely low levels do to PTH? low? high?
abnormal magnesium levels Severe hypomagnesemia (<0.5) - “false block” of CaSR which SUPPRESS PTH Mildly low magnesium - INCREASE PTH release High magnesium - SUPPRESS PTH release
93
_____ causes a “false block” of CaSR which suppresses PTH
Severe hypomagnesemia (<0.5)
94
______ is directly proportional to how abnormal the calcium level is. What is the hallmark symptom?
Hypoparathyroidism tetany due to neuromuscular irritability mild: paresthesias severe: spasms, seizure can see Trousseau’s and Chvostek’s signs
95
neurodegeneration, poor dentition, cataracts are all s/s of _____
chronic hypoparathyroidism poor dentition (calcium leaving the teeth)
96
What is the ACUTE management of hypoparathyroidism? What is the goal?
maintain the airway IV calcium gluconate 10% if there is tetany, seizures, bronchospasm, laryngospasm, prolonged QT interval, refractory heart failure Goal of serum calcium 8-9 mg/dL start PO Calcitriol (1, 25 Vit D) and calcium when the pt can tolerate aka swallow the medication if needed: Magnesium supplementation
97
What forms are available for Calcitriol? Cholecalciferol D3? Ergocalciferol D2?
Calcitriol: capsules solution injection Cholecalciferol: capsule only Ergocalciferol: capsules solution
98
What do you give for hypomagnesium in the case of acute hypoparathyroid management?
Dosing for moderate-severe hypomagnesemia: magnesium sulfate IV 1-2 g every 6 hours Transition to magnesium oxide 400 mg 1-2 times daily PO
99
What is the management of chronic hypoparathyroidism? What is the monitoring for each?
Oral calcium: monitor serum calcium q 3-6 months: need to keep calcium on the LOWER end of normal Vit D and Magnesium supplement PRN ???Pts who are intolerant of, or refractory to calcium/Vit D-> PTH replacement therapy: Teriparatide (Forteo); (administered SQ), Synthetic PTH (1-34), Palopegteriparatide (prodrug)?? ____ Urine and serum calcium, serum creatinine, phosphorus, 25-OH vit D Every 3-6 months initially, then every 6-12 months consider renal US if persistant hypercalciuria
100
What is the prevention of hypoparathyroidism?
cryopreserved parathyroid tissue that are then injected into the brachioradialis, pectoralis or SCM
101
______ Fat soluble vitamin, often from plant sources. What routes does it come in?
ergocalciferol D2 solution capsule/ tablet
102
___ and ___ MOA Stimulates calcium and phosphorus absorption in small intestine. Stimulates calcium reabsorption at renal tubule. Stimulates secretion of calcium from bone into the blood.
Vit D3 and D2
103
____ - Peak effect approximately 1 month with daily dosing. Metabolism - liver, kidney. Elimination - urine
Vit D2: Ergocalciferol and Vit D3: cholecalciferol
104
What are the SE of Vit D2/D3 and Calcitriol? CI?
SE: hypercalcemia - constipation, confusion, fatigue, arrhythmias CI: Allergy to medication Hypercalcemia Hypervitaminosis D
105
_____ Fat soluble vitamin, often from animal sources. What routes does it come in?
Vit D3: Cholecalciferol solution capsule/tablet
106
____ is the metabolically active form of Vit D. What routes does it come in? What kind of pt is it good for? Who usually prescribes it?
1,25 Vitamin D (calcitriol) Solution Capsule IV good choice for pt's who have bad kidneys nephro rx only due to the higher chance of it causing problems due to its already active form
107
______ MOA binds to and activates vitamin D receptor in kidney, parathyroid, intestine, bone. Decreases PTH levels, stimulates calcium absorption, can enhance the effects of PTH on bone.
1,25 Vitamin D (calcitriol)
108
When does 1,25 Vitamin D (calcitriol) start working?
begins working in 2 hours as compared to Vit D2/3 that takes a month to start working
109
_____ is oral calcium salt and is used in hypocalcemia prevention/treatment. What is a potential SE?
calcium carbonate hypercalcemia
110
_____ is IV calcium salt and is given in severe hypocalcemia. What is a potential SE?
Calcium Gluconate hypercalcemia: aka it works too well
111
_____ is an antacid and electrolyte. When do you exercise caution when giving to _____ pt. **What is a SE?
Magnesium Oxide Caution if renal impairment **Diarrhea** GI irritation
112