parasympathetic NS Flashcards
primary neurotransmitter of the PNS
acetylcholine
two types of receptors for the PNS
nicotinic and muscarinic
where are the nicotinic receptors
ganglia of the SNS and PNS
where are the muscarinic receptors
in effector organs of PNS
where is acetylcholinesterase found and what does it do
found in the synaptic cleft
enzyme that breaks down or erases Ach
parasympathomimetic’s do what..?
mimic PNS
effects of parasympathomimetics
SLUDGE MBB (my beautiful bacon)
salivation
lacrimation
urinary incontinence
diarrhea
GI cramps
emesis
miosis
bradycardia
bronchoconstriction
to what do DIRECT acting cholinergic drugs bind
to cholinergic receptor
how do INDIRECT acting cholinergic drugs act
stimulate release of Ach
inhibit acetylcholinesterase
contraindications to cholinergics
COPD
bradycardia
hypotension
GI/GU obstruction
cholinergic crisis EARLY S&S
abd cramps
salivation
flushing
N/V
cholinergic crisis LATE S&S
SH, CCB
Shock
Hypotension
Circulatory changes
Cardiac arrest
Bloody diarrhea
antidote for cholinergic OD
atropine
direct acting cholinergics
bethanechol: urinary retention and GI condition
pyridostigmine: glaucoma and oucular surgery
donepezil: alzheimer’s
affects of anticholinergics
mydriasis
increased HR
bronchodilation
dry mucous membranes
decreased GI motility
decreased salivation and secretions
** urinary retention**
contraindications to antihcholinergics
angle closure glaucoma
acute asthma / resp distress
cardiovascular instability
GI/GU obstruction
SE of anticholinergics
sry mouth
constipation
urinary retention
tachycardia
angina
HA
insomnia
mydriasis
anhidrosis (lack of sweat)
indications for atropine
- cholinergic OD
- cardiac
- pre-op
- bronchodilator
caution w atropine with what pts
advanced hepatic
renal dysfunction
hiatal hernia
ulcerative colitis
benztropine (Cogentin)
- parkinsons
- DOC for symptons of EPS
dicyclomine (bentyl)
IBS
ipratropium (atrovent)
COPD/ chronic asthma
oxybutynin (ditropan)
overactive bladder
neruogenic bladder
S&S of anticholinergic OD
hot as a hare
blind as a bat
dry as a bone
red as a beet
mad as a hatter
scopalamine (transderm scop)
motion sickness
pre-op
