Parasitic Flashcards
Chloroquine, Quinine, Pyrimethamine, atovaquone and proguanil MOA:
Inhibit parasitic DNA synthesis
Mefloquine and Hydroxychloroquine MOA
Inhibit function of lysosomes in parasitic cell
Primaquine MOA
Inhibit mitochondria of parasite
Which antimalarials have high resistance?
Chloroquine
Atovaquone
What is a black box warning associated with Mefloquine
Anxiety, depression, hallucination and SI.
Do not give primaquin in pregnancy.
Antimalarial DIs
QT prolongation meds
Antifolate medications (pyrimethamine)
What meds are used to treat Amoebiasis?
Metronidazole and Diloxanide.
What is the MOA of metronidazole?
Inhibit protein synthesis
Metranidazole is contra-indicated in _______ and can have a _________ effect with _________.
Pregnancy
Disulfiram-like reaction
Alcohol
Drugs used to treat Trypanosomiasis or “sleeping sickness”
Suramin/pentamidine in haemolymphatic stage
Melarsoprol and/or eflornithine for late stage with CNS involvement.
What is eflornithine and melarsoprol used to treat? What is their MOA?
Trypanosomiasis late CNS stage
Melarsoprol MOA disrupt energy production in parasite
Eflornithine MOA = disrupt cellular fxn.
Is Chagas’ disease curable?
No. It is treatable with Nifurtimox, eflornithine and benznidazole but not totally effective.
What is Nifurtimox used to treat?
Chagas diseas in SAmerica
What is the MOA of Suramin?
Used to treat hemolymphatic stage of sleeping sickness
Inhibit parasite enzymes and destroys their organelles.
