Antifungal Flashcards
1
Q
4 classes of anti fungal agents
A
Polyenes - Amphoterocin
Azole - “-azole”
Echinocandins - “-fungin”
Antimetabolite - Flucytosine
2
Q
Polyenes are broad - effective against yeasts, molds and dimorphic fungi.
A
3
Q
What is an important clinical consideration when administering polyenes?
A
Premedicate. With tylenol/NSAID and Benadryl to avoid infusion-related reactions.
4
Q
What is the DOC for aspergilus infections
A
Voriconazole.
5
Q
Which azoles cross BBB? What does this mean?
A
Fluconazole + Variconazole
Used to Tx fungal meningitis.
6
Q
DDIs with azoles?
A
Hepatic clearance meds
QT prolongation meds
7
Q
If you see an “azole” med, think ______
A
DIs!!
8
Q
Which antifungals are commonly used in empiric therapy?
A
Polyenes
