parasites and vectors Flashcards
Human African trypanosomiasis- in West Africa ?
- Trypanosoma brucei gambiense (gHAT)
- Exclusively human reservoir
What is the causative agent of
Human African trypanosomiasis in East Africa ?
- ## Trypanosoma brucei rhodesiense (rHAT)
What is the Vector for American Trypanosomiasis ?
Triatomine bugs
whats the causative agent for american trypansomiasis?
Trypansoma Cruzii
Vector for gHAT?
Glossina palpalis group of Tsetse fly
Vector of rHAT?
Glossina Morsitans group of Tsetse fly
parasite cause Chagas disease ?
Trypanosoma cruzi
Vector for Chagas ?
- Family : reduviid bug:
-Subfamily :Triatomine bugs : - In wild environment in Amazona region and central America:
1- Triatoma infestans
2- Triatoma braziliensis
3- Triatoma sordida
4- Panstrongylus megistus.
*In south cone - Brazil , Argentina , Peru , Bolivia
(in houses night biting) :
5- Rhodnius prolixus
Infective stage of plasmodium to human?
Sporozoite
plasmodium spp that has hypnozoite stage ?
p vivax
P ovale
plasmodium that can cause band form in erythrocytic stage on microscopy?
P malariae
Causes of tertian malaria ?
P vivax
p ovale ( but doesn’t sequestrate in microvasculature)
quartan Malaria
p malariea
plazmodium that cause enlarged RBC and classic comet form on micrscoy
p ovale
How to differentiate b/w scoleces of Tania saginatum, Taenia solium , E chinococcus granulosus and diphyllobothrium latum?
1- Saginatum: not hooks
and has 4 sucking disks
2- Solium: Hooked 4 sucking disks
3- E granulosus: 30-36 hooks in 2 rows and 4 sucks
4- diphylobothrium latum: almond shape and with pair of suctorial grooves called bothria
Diseases caused by Taenia solium?
1- Taeniasis (Pork tape worm)
2- Cysticercosis
T/F:
E granulosus can grow into adult form inside human body ?
F
E granulosus can only mature into an adult form and produce eggs in canine
Mode of infection in Taeniasis and cysticercosis?
In Taeniasis : by ingestion of the larvae in pork flesh
In Cysticercoses: By ingestion of the embryonated eggs (oncospheres) from patients own stool or other human carrier
What is the most common tape worm infection in human??
Hymenolepis nana
(Dwarf tapeworm)
Mode of infection by Hymenolepis nana ?
1- ingestion of the eggs in contaminated food and water
2- accidentally ingest cysticercoid-infected arthropod
Mode of infection of Hymenolepis diminuta (rat tapeworm) ?
By ingestion of intermediate host (Grain weevils and earwigs) containing larva stage
(mainly in precooked cereals)
what is the infective stage of Diphyllobothrium latum to mammals??
Plerocercoid larvae in raw and undercooked fishes
Definitive host of Diphyllobothrium latum??
Human
bears
cats
dogs
(fish eaters)
what are the 2 required intermediate host for Diphyllobothrium latum lifecycle ?
1- the copepods
2- fish
what is the only cestode that have an operculated eggs ?
Diphyllobothrium latum
Mode of infection with dipylidium caninum?
what is the age group at risk ?
what is the diagnostic stage ?
- BY ingestion of Ctenocephalides fleas containing larvae
- Mainly affect infant and young kids with close relation with pets
- Diagnostic stage: Gravid proglottid in stool ( eggs are not seen in human stool)
Mode of infection of the liver fluke Fasciola hepatica?
and what is the intermediate ( secondary) host ?
What is the diagnostic stage in human?
Undercooked watercress which contain the encysted larval metacercaria
Intermediate host: water snails
diagnostic stage : operculated oval eggs in stool
T/F :
Fasciola hepatica eggs are operculated and identical to the eggs of Fasciolopsis buski ( giant intestinal fluke)
T
Opisthorcis sinensis (Chinese liver fluke ) mode of infection?
By Ingestion of undercooked / raw fish containing metacercaria
where is the anatomical journey of both Fasciola hepatica and Clonorchis sinensis in human body??
Fasciola hepatica:
larva penetrate intestinal wall then peritoneal cavity then penetrate liver capsule to reach bile duct where they mature
Clonorchis sinensis parasite pass from intestine via ampula of vater and then reach the liver by bile ducts
mode of human infection by giant intestinal fluke(fasciolopsis buski) ?
by ingestion of contaminated water chestnut
What is the mode of infection of paragonimus westermani?
by ingesting the undercooked crap meat containing metacercaria
which cancer can Opisthorchis sinensis infection causes??
Cholangiocarcinoma
what is the Size and shape of Paragonimus westermani adult worms ?
12 by 4 mm
resembles a coffee bean in size, shape, and color
T/F
Entamoeba histolytica can be zoonotic infection ?
F
what is the only protozoal diarrheal infection which can cause eosinophilia ??
Isospora belli
What are the CNS infections that can caused by Amoebiasis and Naegleria fowleri ?
1- Amoeba dysentery:
Amoebic brain abscess
2- Acanthamoeba spp: slowly progressive Amoebic granulomatous encephalitis - GAE
3- Naegleria fowleri :
Amoebic Meningoencephalitis
What are the spp that can cause GAE (Granulomatous amoebic encephalitis)
Free living amoeba spp:
1- Acanthamoeba
2- Balamuthia mandrillaris
3- Sappinia
What is the cause of scrup typhus (bush typhus) ? and what is the vector ? Reservoir ?
Orientia tsutsugamushi
The vector is the infected larval trombiculid mites, commonly known as chiggers
Wild rats are the natural reservoir
What is the cause and vector of African tick bite fever ?
Caused by: Rickettsia Africae
Vector is Amblyomma tick
What is the cause and vector of Queensland tick typhus
Rickettsia australis
Vector is Ixodes tick
What are the DEBONEL/TEBOLA?
What is the cause and vector?
TIBOLA is the tick‐born lymphadenitis
DEBONEL: Dermacentor‐borne necrosis, erythema, lymphadenopathy
-Caused by : Rickettsia slovaca is the causative agent
-Transmitted by ticks of the genus Dermacentor
What is the vector of Brugia timori?
Mansonia Mosquitoes
What are the diseases that can be transmitted by Aedes mosquitoes?
LF
YF
DHF
Zika
Chikungunya
what is the difference b/w Loaloa Encephalopathy and Mazotti reaction?
Loaloa Encephalopathy occues in Loa loa treatment with Ivermectin (commonest) and DEC (Less common)
Mazotti reaction occurs when Onchocerciasis treatment with DEC
Treatment of choice of Loa loa?
DEC
If no detectable microfilaremia :
9 mg/kg/day for 21 days
If detectable Microfilaremia : gradual increase dose of DEC from 1 mg/kg/day up to 9 mg/kg/day 21 days
Treatment of choice of LF?
DEC 6mg/kg/day for 1 or 12 days
If Tropical pulmonary eosinophilia for 14-21 days
Treatment of Oncocerca volvulus
1- To kill microfilariae:
ivermectin 150 mcg/kg orally in one dose
every 6 months
2- to kill macrofilariae:
doxycycline* 200 mg orally daily
for 6 weeks
Countries that have reported cases of Trypanosoma brucei gambiensis ?
DRC (Commonest)
Cameroon / Congo
Central Africa
S Sudan / Chad
E Guinea / Guinea/ Gabon
Countries that have reported cases of Trypanosoma brucei rhodesiense ?
Malawi
Zambia
Uganda
Tanzania
The vector of Trypanosoma brucei rhodesiense ?
Tsetse fly ( Glossina Morsitans )
The Vector of Trypanosoma brucei gambeinsis
Tsetse fly (Glossina palpalis)
(single genital ulcers)
1- Cause of Chancroids?
2- Lymphogranuloma venerum?
3- Granuloma inguinale ?
1- Haemophilus ducreyi
2- Chlamydia trachomatis (LGV serovar) L 1 ,L2 ,L3
3- Klebsiella granulomatis (donovanosis)
presentation and treatment of LGV?
(Chlamydia trachomatis)
1- Main presentation is Proctitis (bloody discharge, tenesmus, or ulceration)
2- inguinal lymphadenopathy with bubo formation
3- Single painless genital ulcer
Tx: Doxycycline 100 mg orally 2 times/day for 21 days or:
- Azithromycin 1 g once weekly for 3 weeks
Or:
Erythromycin base 500 mg orally 4 times/day for 21 days
What is the cause , Presentation and Tx of Granuloma Inguinale (Donovanosis)?
- Klebsiella granulomatis .
- slowly progressive Painless single genital ulcers Without regional LN
-subcutaneous granulomas (pseudobuboes) which are highly vascular (beefy red appearance) and can bleed.
Tx
First line:
Azithromycin 1 gm orally once weekly or 500 mg daily for > 3 weeks and until all lesions have completely healed
alternative :
Doxy , erythro ,cotrim