Paraneoplastic Syndromes Flashcards
Cushing Syndrome
Endocrinopathy
Forms of Cancer: Small cell carcinoma of lung, pancreatic carcinoma, neural tumors
Casual Mx: ACTH or ACTH-like substance
Syndrome of inappropriate ADH secretion
Endocrinopathy
Forms of Cancer: Small cell carcinoma of lung, intracranial neoplasm
Casual Mx: ADH or atrial natriuretic hormones
Hypercalcemia
Endocrinopathy
Forms of Cancer: Squamous cell carcinoma of lung, Breast carcinoma, renal carcinoma, Adult T-Cell leukemia/lymphoma
Casual Mx: Parathyroid hormone related protein (PTHRP), TGFalpha, TNF IL-1
Hypoglycemia
Endocrinopathy
Forms of Cancer: Ovarian carcinoma, fibrosacroma, other mesenchymal sarcomas
Casual Mx: Insulin or insulin-like substance
Polycythemia
Endocrinopathy
Forms of Cancer: Renal carcinoma, Cerebellar hemangioma, hepatocellular carcinoma
Casual Mx: Erythropoietin
Myasthenia
Nerve and muscle syndrome
Forms of Cancer: Bronchogenic carcinoma, thymic neoplasms
Casual Mx: Immunologic
Disorders of the central and peripheral nervous system
Nerve and muscle syndrome
Forms of Cancer: Breast carcinoma
Casual Mx: ?
Acanthosis Nigracans
Dermatologic disorders
Forms of Cancer: Gastric carcinoma, lung carcinoma, uterine carcinoma
Casual Mx: Immunologic, secretion of epidermal growth factor
Dermatomyositis
Dermatologic disorders
Forms of Cancer: Bronchogenic carcinoma, breast carcinoma
Casual Mx: Immunologic
Hypertrophic osteoarthropathy and clubbing of fingers
Osseous, articular and soft tissue changes
Forms of Cancer: Bronchogenic carcinomas, thymic neoplasms
Casual Mx: Unknown
Venous thrombosis (Trosseau phenomenon)
Vascular and hematologic changes
Forms of Cancer: Pancreatic carcinoma, bronchogenic carcinoma, other cancers
Casual Mx: Tumor products (mucins that activate clotting)
Disseminated intravascular coagulation
Vascular and hematologic changes
Forms of Cancer: Acute promyelocytic leukemia, prostatic carcinoma
Casual Mx: Tumor factors that activate clotting
Nonbacterial thrombotic endocarditis
Vascular and hematologic changes
Forms of Cancer: Advanced cancers
Casual Mx: Hypercoagulability
Red cell aplasia
Vascular and hematologic changes
Forms of Cancer: Thymic neoplasms
Casual Mx: Unknown
Nephrotic syndrome
Other
Forms of Cancer: Various cancers
Casual Mx: Tumor antigens, immune complexes
