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Paraneoplastic Syndromes Flashcards

1
Q

ACh receptor, muscle

A

Myasthenia gravis

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2
Q

ACh receptor, a3 ganglionic

A

Autonomic neuropathy

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3
Q

AMPA receptor

A

Limbic encephalitis

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4
Q

AQP4 receptor antibodies

A

Neuromyelitis optica

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5
Q

CASPR2

A

Neuromyotonia

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6
Q

DPPX

A

Encephalitis, brainstem syndromes, ataxia and diarrhea

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7
Q

GABA-A receptor

A

Status epilepticus, cortical and subcortical lesions

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8
Q

GABA-B receptor

A

Limbic encephalitis, SE

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9
Q

Glycine receptor

A

Progressive encephalomyelitis with rigidity and myoclonus (PERM), Stiff Person Syndrome

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10
Q

IgLON5

A

Sleep disorder, bulbar symptoms, mimics PSP

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11
Q

LGI1

A

Limbic encephalitis with faciobrachial dystonic seizures

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12
Q

mGlu receptor 1

A

Ataxia

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13
Q

mGlu receptor 5

A

Ophelia syndrome (limbic encephalitis)

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14
Q

NDMA receptor

A

encephalitis

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15
Q

PCA-Tr/DNER

A

Cerebellar ataxia, brainstem encephalitis

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16
Q

P/Q-type and N-type voltage gated calcium channel

A

Lambert-Eaton myasthenic syndrome

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17
Q

Thymoma antibodies

A 
Ach receptor, muscle
AQP4
GABA-A
Glycine receptor
LGI1
CRMP-5/anti-CV2
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18
Q

Small cell lung cancer

A 
AMPA receptor
GABA-B receptor
P/Q-type or N-type voltage gated calcium channels
ANNA-1/Anti-Hu
ANNA-2/Anti-Ri
ANNA-3
CRMP-5/Anti-CV2
GAD65
Neuronal intermediate filament light
PCA-2/MAP1B
Recoverin
TRIM46
Zic4
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19
Q

Hodgkin lymphoma

A

mGlu receptor 1
mGlu receptor 5
PCA-Tnr/DNER

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20
Q

Ovarian teratoma/Tumors

A

Anti NMDAr
CARP VIII
GRAF1/ARHGAP26
ITPR1

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21
Q

Adenocarcinomas

A

ACh receptor, a3 ganglionic

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22
Q

Myasthenia gravis

A

Thymoma

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23
Q

Autonomic neuropathy

A

Adenocarcinoma

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24
Q

Limbic encephalitis

A 
Thymic tumors/thymomas
Hodgkin lymphoma (mGlu5)
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25
Neuromyotonia
CASPR2
26
Status epilepticus
GABA-A, GABA-B
27
Ataxia
``` DPPX* - with GI, brainstem mGlu receptor 1 CARP VIII GRAF1/ARHGAP26 Kelch-like protein Neurochondrin Neuronal intermediate filament light ```
28
Faciobrachial dystonic seizures
LGI1
29
Stiff Person Syndrome
Glycine antibodies | Amphiphysin antibodies
30
AGNA/SOX1
Lambert-Eaton
31
AGNA/SOX1
Small cell lung cancer
32
Amphiphysin antibodies
Stiff-person syndrome
33
ANNA-1/Anti-Hu
Small cell lung cancer Thymoma Neuroblastoma (kids)
34
ANNA-2/Anti-Ri
Small cell lung cancer, | Breast Cancer
35
ANNA-3
Small Cell Lung Cancer
36
BR serine/Threonine Kinase 2
Small Cell Lung Cancer
37
CARP VIII
Melanoma | Ovarian tumors
38
Melanoma
CARP VIII
39
CRMP-5/Anti-CV2
Small Cell Lung Cancer
40
GAD65
Small Cell Lung Cancer
41
GFAP
Teratoma
42
Teratoma
GFAP
43
ITPR1
Ovarian cancer
44
Kelch-like protein
Seminoma
45
Ma1, Ma2
``` Testicular cancer (Ma2) Diverse cancers (Ma1, Ma2) ```
46
Neuronal Intermediate Filament Light
Neuroendocrine tumors (small cell, Merkel cell carcinoma)
47
Neurochondrin
Uterine Cancer
48
PDE10A
Lung cancer Renal cancer Pancreatic cancer
49
PCA-1/CDR2
Ovarian endometrial Breast
50
PCA-2/MAP1B
Small Cell Lung Cancer
51
Protein Kinase C
Non-small cell lung | Hepatobiliary Adenocarcinoma
52
Recoverin
Small Cell Lung
53
TRIM46
Small Cell Lung
54
Zic4
Small Cell Lung
55
Breast Cancer
Amphiphysin ITPR1 Ma1,Ma2 PCA-1/CDR2
56
Uterine cancer
Neurochondrin
57
Non-small cell lung cancer
Protein Kinase C
58
Hepatobiliary adenocarcinoma
Protein Kinase C
59
Lambert Eaton Myesthenic syndrome
AGNA/SOX1 | P/Q and N-type voltage gated calcium channel
60
OMAS
ANNA-1/Anti-Hu (kids) | ANNA-2/Anti-Ri (adults)
61
Sensory Neuropathy
ANNA-1/Anti-Hu | Paraproteinemias (Waldenstrom IgM)
62
Anti-MDA-5 antibodies
Dermatomyositis with ILD
63
Mi-2 Antibodies
Dermatomyositis
64
Jo-1 Antibodies
Dermatomyositis
65
SRP antibodies
necrotising myopathy
66
HMGCR antibodies
Necrotizing myopathy
67
Necrotizing myopathy
HMGCR antibody | SRP Antibody
68
Dermatomyositis
Mi-2 Jo-1 Anti-MDA-5 (with ILD)

Lynne Study Flashcards (9 decks)

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