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lynne study flashcards > Paraneoplastic Syndromes > Flashcards

Paraneoplastic Syndromes Flashcards

1
Q

ACh receptor, muscle

A

Myasthenia gravis

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2
Q

ACh receptor, a3 ganglionic

A

Autonomic neuropathy

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3
Q

AMPA receptor

A

Limbic encephalitis

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4
Q

AQP4 receptor antibodies

A

Neuromyelitis optica

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5
Q

CASPR2

A

Neuromyotonia

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6
Q

DPPX

A

Encephalitis, brainstem syndromes, ataxia and diarrhea

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7
Q

GABA-A receptor

A

Status epilepticus, cortical and subcortical lesions

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8
Q

GABA-B receptor

A

Limbic encephalitis, SE

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9
Q

Glycine receptor

A

Progressive encephalomyelitis with rigidity and myoclonus (PERM), Stiff Person Syndrome

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10
Q

IgLON5

A

Sleep disorder, bulbar symptoms, mimics PSP

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11
Q

LGI1

A

Limbic encephalitis with faciobrachial dystonic seizures

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12
Q

mGlu receptor 1

A

Ataxia

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13
Q

mGlu receptor 5

A

Ophelia syndrome (limbic encephalitis)

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14
Q

NDMA receptor

A

encephalitis

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15
Q

PCA-Tr/DNER

A

Cerebellar ataxia, brainstem encephalitis

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16
Q

P/Q-type and N-type voltage gated calcium channel

A

Lambert-Eaton myasthenic syndrome

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17
Q

Thymoma antibodies

A 
Ach receptor, muscle
AQP4
GABA-A
Glycine receptor
LGI1
CRMP-5/anti-CV2
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18
Q

Small cell lung cancer

A 
AMPA receptor
GABA-B receptor
P/Q-type or N-type voltage gated calcium channels
ANNA-1/Anti-Hu
ANNA-2/Anti-Ri
ANNA-3
CRMP-5/Anti-CV2
GAD65
Neuronal intermediate filament light
PCA-2/MAP1B
Recoverin
TRIM46
Zic4
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19
Q

Hodgkin lymphoma

A

mGlu receptor 1
mGlu receptor 5
PCA-Tnr/DNER

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20
Q

Ovarian teratoma/Tumors

A

Anti NMDAr
CARP VIII
GRAF1/ARHGAP26
ITPR1

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21
Q

Adenocarcinomas

A

ACh receptor, a3 ganglionic

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22
Q

Myasthenia gravis

A

Thymoma

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23
Q

Autonomic neuropathy

A

Adenocarcinoma

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24
Q

Limbic encephalitis

A 
Thymic tumors/thymomas
Hodgkin lymphoma (mGlu5)
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25
Q

Neuromyotonia

A

CASPR2

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26
Q

Status epilepticus

A

GABA-A, GABA-B

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27
Q

Ataxia

A 
DPPX* - with GI, brainstem
mGlu receptor 1
CARP VIII
GRAF1/ARHGAP26
Kelch-like protein
Neurochondrin
Neuronal intermediate filament light
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28
Q

Faciobrachial dystonic seizures

A

LGI1

29
Q

Stiff Person Syndrome

A

Glycine antibodies

Amphiphysin antibodies

30
Q

AGNA/SOX1

A

Lambert-Eaton

31
Q

AGNA/SOX1

A

Small cell lung cancer

32
Q

Amphiphysin antibodies

A

Stiff-person syndrome

33
Q

ANNA-1/Anti-Hu

A

Small cell lung cancer
Thymoma
Neuroblastoma (kids)

34
Q

ANNA-2/Anti-Ri

A

Small cell lung cancer,

Breast Cancer

35
Q

ANNA-3

A

Small Cell Lung Cancer

36
Q

BR serine/Threonine Kinase 2

A

Small Cell Lung Cancer

37
Q

CARP VIII

A

Melanoma

Ovarian tumors

38
Q

Melanoma

A

CARP VIII

39
Q

CRMP-5/Anti-CV2

A

Small Cell Lung Cancer

40
Q

GAD65

A

Small Cell Lung Cancer

41
Q

GFAP

A

Teratoma

42
Q

Teratoma

A

GFAP

43
Q

ITPR1

A

Ovarian cancer

44
Q

Kelch-like protein

A

Seminoma

45
Q

Ma1, Ma2

A 
Testicular cancer (Ma2)
Diverse cancers (Ma1, Ma2)
46
Q

Neuronal Intermediate Filament Light

A

Neuroendocrine tumors (small cell, Merkel cell carcinoma)

47
Q

Neurochondrin

A

Uterine Cancer

48
Q

PDE10A

A

Lung cancer
Renal cancer
Pancreatic cancer

49
Q

PCA-1/CDR2

A

Ovarian
endometrial
Breast

50
Q

PCA-2/MAP1B

A

Small Cell Lung Cancer

51
Q

Protein Kinase C

A

Non-small cell lung

Hepatobiliary Adenocarcinoma

52
Q

Recoverin

A

Small Cell Lung

53
Q

TRIM46

A

Small Cell Lung

54
Q

Zic4

A

Small Cell Lung

55
Q

Breast Cancer

A

Amphiphysin
ITPR1
Ma1,Ma2
PCA-1/CDR2

56
Q

Uterine cancer

A

Neurochondrin

57
Q

Non-small cell lung cancer

A

Protein Kinase C

58
Q

Hepatobiliary adenocarcinoma

A

Protein Kinase C

59
Q

Lambert Eaton Myesthenic syndrome

A

AGNA/SOX1

P/Q and N-type voltage gated calcium channel

60
Q

OMAS

A

ANNA-1/Anti-Hu (kids)

ANNA-2/Anti-Ri (adults)

61
Q

Sensory Neuropathy

A

ANNA-1/Anti-Hu

Paraproteinemias (Waldenstrom IgM)

62
Q

Anti-MDA-5 antibodies

A

Dermatomyositis with ILD

63
Q

Mi-2 Antibodies

A

Dermatomyositis

64
Q

Jo-1 Antibodies

A

Dermatomyositis

65
Q

SRP antibodies

A

necrotising myopathy

66
Q

HMGCR antibodies

A

Necrotizing myopathy

67
Q

Necrotizing myopathy

A

HMGCR antibody

SRP Antibody

68
Q

Dermatomyositis

A

Mi-2
Jo-1
Anti-MDA-5 (with ILD)

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