Paraneoplastic Syndrome Flashcards

1
Q

What are dermatological paraneoplastic syndromes

A

Achanthosis nigricans

Dermatomyositiss

Seborrheic keratosis

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2
Q

What are dermatological paraneoplstic syndrome occur in lung cancer

A

Acanthosis nigricans

Dermatomyositis

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3
Q

Explain about achantosis nigricans

A

Occurs in
stomach cancer

Lung cancer

Uterine malignancy

Hyperpigmentation occurs here and thickening of skin occurs

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4
Q

Dermatomyositis

A

Seen in
Lung cancer
Breast cancer

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5
Q

Seborrheic keratosis

A

Stomach

Breast

Colon

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6
Q

What is paraneoplastic syndrome?

A

Here it cannot be explained
Metastasis
Hormones indigenous
Directi spread

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7
Q

What is the significance paraneoplastic syndrome

A

Metastasis mimic

Indicate the worsen condition

May be initial manifestation

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8
Q

Types of paraneoplastic syndrome

A
Endocrinopathies
Dermatological 
Neuromuscular
Osseus or soft tissues changes 
Vascular haemotogical
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9
Q

Endocrinopathis features

A
Here first we are gonna learn headings
Hypercalcemia
Cushing syndrome 
Polychethemis
Siadh
Hypoglycaemia
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10
Q

How hypercalcemia occur

A

Hypercalcemia occurs in

Lung cancer
Kidney cancer
Breast cancer

Most common paraneoplastic syndrome

Occurs due to presence of prostaglandins and the path like peptides

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11
Q

Explain Cushing syndrome as the paraneoplastic syndrome

A

It occurs in
Small cell carcinoma of lung
Carcinoid tumour

Most common endocrine paraneoplastic syndrome

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12
Q

Siadh

A

Increased ADH
In severe cases the hyponatrimea

Occurs in
Small cell lung cancer
Cns tumour

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13
Q

Hypoglycaemia is seen in

A

Fibrosarcoma

Ovarian cancer

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14
Q

Polycythemia as the neoplastic syndrome

A

Occurs in
Kidney cancer
Hepato cellular carcinoma
Cerebellar hemangioblastoma

It occurs due to increase in erythropoietin

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15
Q

What are the paraneoplastic syndrome occurs in lung. Cancer

A

Cushing syndrome
Hypercalcemia
Siadh

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16
Q

Examples of vascular paraneoplastic syndromes

A

Venous thrombophlebitis ( migratory thrombophlebitis)

Marantic endocarditis/ non bacterial thrombotic endocarditis

Anemia seen in thymoma

17
Q

Explain the venous thrombophlebitis

A

Caused due to the mucin
Migratory thromnhophLebitis,

trousseau sign

Seen In

Pancreatic cancer
AML-M3
Bronchogenic cancer/ adrenocarcinoma of lung

18
Q

Explain marantic endocarditis/ non bacterial thrombotic endocarditis

A

Seen in pancreatic cancer

AML-m3

Due to mucin

19
Q

Neuromuscular paraneoplastic syndromes

A

Myasthenia gravies

Lamberts eaten syndrome

20
Q

Myasthenia bra is in paraneoplastic syndromes

A

Thymoma

Lung cancer

21
Q

Lambert eaten syndrome

A

Lung cancer

22
Q

Limbic encephalitis

A

Lung cancer

Small cell

23
Q

Sub acute cerebellar deneratiom

A

Endometrial cancer

Ovarian cancer

Breast cancer

24
Q

Opsoclonu random eye movement

A

Small cell lung cancer

Seen in neuroblastoma

25
Q

How Osceous and soft tissue are effected

A

Hypertrophic Osteo arthropathy
Causes the clubbing of fingers

Lung cancer