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PAthology > Necrosis > Flashcards

Necrosis Flashcards

1
Q

Necrosis

A

Death Of cells and tissues in the living animal

Necrosis is localised area of death of tissues followed later by degradation of tissue by hydrologic enzymes liberated from death cells

Inflammatory reaction will be there

Always pathological and occurs in the group of cells

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2
Q

What the Types of necrosis

A

CCCFF

Coagulation necrosis

Colliquative /liquefaction

Caseous

Fat

Fibrinoid

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3
Q

Coagulative necrosis

A

Architectural details are there but cytoplasmic and nuclear features are absent

Tissues can be recognised

Denaturation of structural and enzymatic proteins block proteolysis

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4
Q

Causes of the

A

Ishchemia except brain all organs will undergo this coagulative necrosis

Mild burns

Zenkers degeneration necrosis

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5
Q

Grossly how the coagulative necrosis

A

Early: pale ,firm,slightly swollen

With progressing more yellowish ,softer,shrunken

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6
Q

Microscopic features of the coagulative necrosis

A

Thomb stones.

Necrotic cells are swollen and more eosinophilic

Pyknosis, karyohexisis,karylosis

Inflammatory cells

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7
Q

Coagulative necrosis

A

Most common
Architectural details are present but nuclear and cytoplasmic details

Causes are ischemic
Zenkers diverticulum
Thermal injury

Grossly pale ,firm ,swollen,yellow

Microscopically = thomb stones
Pyknosis, karyolysis, karyohexisis,

Inflammatory cells

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8
Q

Liqufactive necrosis

A

Here the hydrologic enzymes are more so these,I fluid material is formed

No architectural and cytoplasmic and nuclear features are present

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9
Q

Causes of liquefaction necrosis

A

Pyogenic bacterial infections attract neutrophils
Bacterial and leukocytes enzymes liquefy dead cells amd tissues

Ischemic necrosis of brain

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10
Q

Gross appearance of liquefactive necrosis

A

Affected area is
Soft and liquefied central containing necrotic debris

Later cyst wall is formed

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11
Q

Liqufactive necrosis

A

Semi solid
Architectural details are are lost and nuclear details are also lost

Causes
pyogenic infections
Brain

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12
Q

Caseous necrosis

A

Cheese like dead tissue is converted into
Homogeneous granular mass resembles the cottage cheese

No archetectural details as well as cytoplasmic and nuclear details are lost

Accumulation of amorphous debris within an area of necrosis

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13
Q

Causes of caseous necrosis

A

Mycobacterium tuberculosis
Sphylis
Fungi(histoplasmosis and coccidomucosis)

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14
Q

Gross appearance of caseous

A

Dry cheese and are soft,granular and yellowish

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15
Q

Fat necrosis

A

Occurs in the fat laid anatomical places
Breast,pancreas,(mesentric fat necrosis) omentum

Breast ( fat and pendulous breast)

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16
Q

Grossly appearance of fat necrosis

A

Yellowish white and firm deposits

Due to the formation calcium soaps chalky white appearance it makes the necrosis foci firmer

17
Q

How calcium soaps are formed

A

Acute pancreatitis lo due to damage of pancreas liberation of lipases are done from the damaged tissues

This causes the necrosis of pancreas and fat

Then the adipocytes gets ruptures and glycerol and fatty acids are released these react with calcium and form calcium soaps

18
Q

Microscopic view of the fat necrosis

A

Necrosis cell have-cloudy appearance

Surrounded by inflammatory reaction

Calcium soaps appear as amorphous granular and basophils material

19
Q

Fibrinoid necrosis

A

Deposition of fibrin like material
It has same staining properties like the fibrinogen with phosphate tungsten acid haemotoxlin staining

IIT occurs mostly in the blood vessels

20
Q

Causes of the fibrinoid necrosis

A

Occurs mostly in the immune diseases

Vasculitis ,Arthur’s reaction, nuclear

Arterioles in Hypertension , peptic ulcers

21
Q

Microscopic features of fibrinoid necrosis

A

Identified by the eosinophilic hyaline like material deposits on the vessels walls

Necrotic focus is surrounded by the nuclear debris of neutrophils

Local haemorrhage may be causesd due to the rupture

22
Q

Caseous necrosis

A

Dead tissue converted to homogeneous granular mass resembling cottage cheese

Architectural details are not present
Accumulation of amorphous debris with in an area of necrosis

23
Q

Cause of caseous necrosis

A

Mycobacterium tuberculosis
Syphilis
Fungi

24
Q

Gross appearance of caseous necrosis

A

Dry cheese and soft granular yellowish

Partly attributed to the histotoxic effects of liposaccarided present in the capsule of mycobacterium tuberculosis

25
Q

Microscopic features of caseous necrosis

A

Centre of necrosis foci contain

Structureless eosinophilic material having scattered granular debris and disintegrated nuclei

Surrounded tissue show granulomatous inflammatory reaction

PAthology (10 decks)

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