Paralytics

Question 1

Succinylcholine ED95?

Answer 1

0.3 mg/kg

Question 2

Succinylcholine intubating dose?

Answer 2

Typical dose is from 0.3-1.0 mg/kg.

Classic dose 1.0 mg/kg. Newer 0.5-0.6 mg/kg.

Question 3

Succinylcholine onset and duration?

Answer 3

Typical onset is 45-60 seconds at 1.0 mg/kg

Duration is about 8-15 minutes for 90% recovery

Question 4

How to treat hyperKalemia d/t Succinylcholine admin?

Answer 4

1. Hyperventilation
2. 1-2mg Calcium Chloride IV
3. 50cc D50W IV + 10 units IV insulin (Adults) or 1.0ml/kg D50W + 0.15 U/kg insulin
   (Pediatrics).
4. Sodium Bicarbonate 1 mEq/kg

Question 5

Succinylcholine Side effects?

Answer 5

HyperKalemia
Malignant Hyperthermia
Increased IOP, ICP, Intra-gastric press.
Myalgias
Massetar Spasm

Question 6

What is Phase II Block?

Answer 6

Excessively large doses, repeat doses of SUX, or SUX infusions can result in what is called a phase II block which acts more like a non-depolarizing blockade
of the NMJ.