Paralytics

Question 1

How does lithium potentiate (increase the action) NMBDs?

Answer 1

1) Activates K channels in prejunctional neurons > interference of AP transmission to the nerve terminal

2) Activates K channels on the postsynaptic myocytes > mm contraction inhibition

Question 2

If a patient is on lithium, how may induction medications be adjusted?

Answer 2

If giving NMBDs, the overall dose should be reduced as it potentiates their action.