Diuretics

Question 1

Mannitol MOA and site of action?

Answer 1

prevents water reabsorption @ the proximal tubule and descending loop of Henle

Question 1

Acetazolamide MOA and site of action?

Answer 1

Inhibits carbonic anhydrase @ proximal tubule

Question 2

Loop diuretic (furosemide) MOA and site of action?

Answer 2

inhibits the Na+-K+-Cl- transporter @ the thick ascending loop of Henle

Question 3

Thiazide diuretic (HCTZ and chlorthalidone) MOA and site of action?

Answer 3

Inhibits the Na+-Cl- cotransporter @ the distal convoluted tubule

Question 4

Potassium sparing diuretics (spironolactone) MOA and site of action?

Answer 4

Inhibits aldosterone receptors @ the distal convoluted tubule

Question 5

Potassium sparing diuretics (triamterene) MOA and site of action?

Answer 5

Inhibts the ENac (epithelial sodium channel) in the collecting ducts