Paracetamol Poisoning

Question 1

how many tablets/grams may be fatal?

and in terms of mg/kg?

Answer 1

24 tablets / 12 grams

150mg/kg

Question 2

Signs and symptoms?

Answer 2

Vomiting
Jaundice and encephalopathy from liver damage
AKI

Question 3

Tx

1) what do you use for GI decontamination if they present <4h after overdose?
2) if less than 10-12h after overdose?

Answer 3

1) Activated charcoal 1g/kg

2) Acetylcysteine