Papovaviridae

Question 1

Characteristics

Answer 1

Icosahedral capsid virion,

Double-stranded circular DNA,

Question 2

Virus encode proteins that promote cell growth by

Answer 2

Binding to the cellular growth-suppressor proteins p53 and p105RB. Polyoma T antigen binds to p105RB and p53. E6 binds to p53, and E7 binds to p105RB.

Question 3

Papillomavirus is acquired by

Answer 3

Close contact

Question 4

Polyomavirus is acquired by

Answer 4

Respiratory route-spread by viremia to the kidneys early in life

Question 5

Explain Progressive multifocal leukoencephalopathy (PML)

Answer 5

JC virus partially transforms astrocytes and kills oligodendrocytes, causing characteristic lesions and sites of demyelination.

Question 6

Describe BK virus

Answer 6

BK virus is ubiquitous and is not associated with serious disease.

Question 7

Modes of control for papovaviridae

Answer 7

None

Question 8

Skin warts: Plantar warts

Answer 8

1

Question 9

Skin warts: Common warts

Answer 9

2,4

Question 10

Skin warts: flat warts

Answer 10

3,10

Question 11

Skin warts:

Epidermodysplasia verruciformis

Answer 11

5,8,17,20,36

Question 12

Benign head and neck tumors:

Laryngeal papilloma

Answer 12

6,11

Question 13

Benign head and neck tumors:

Oral papilloma

Answer 13

6,11

Question 14

Benign head and neck tumors:

Conjunctival papilloma

Answer 14

11

Question 15

Anogenital wart:

Condyloma acuminatum

Answer 15

6,11

Question 16

Cervical intraepithelial neoplasia, cancer

Answer 16

16,18

Question 17

Viruses under this and diseases

Answer 17

Papillomavirus - warts
Polyomavirua:
-BK virus - renal disease
-JC virus - Progressive multifocal leukoencephalopathy

Question 18

Common warts other name

Answer 18

Verruca vulgaris.

Occurs in fingers, hands, feet, and face.

Question 19

Plantar warts other name

Answer 19

Verruca plantaris

Question 20

Flat warts other name

Answer 20

Verruca lanta.

Autoinoculation from trauma, such as shaving, is a common means of viral spread.

Question 21

Cytology detects

Answer 21

Koilocytotic cells

Question 22

Method of choice for papillomavirus

Answer 22

In situ DNA probe analysis,

Polymerase chain reaction

Question 23

Describe koilocytosis

Answer 23

Also called vacuolated cytoplasm.

Perinuclear cytoplasmic vacuolization.

Question 24

Capsid virus is

Answer 24

Resistant to inactivation