Papovaviridae Flashcards
Characteristics
Icosahedral capsid virion,
Double-stranded circular DNA,
Virus encode proteins that promote cell growth by
Binding to the cellular growth-suppressor proteins p53 and p105RB. Polyoma T antigen binds to p105RB and p53. E6 binds to p53, and E7 binds to p105RB.
Papillomavirus is acquired by
Close contact
Polyomavirus is acquired by
Respiratory route-spread by viremia to the kidneys early in life
Explain Progressive multifocal leukoencephalopathy (PML)
JC virus partially transforms astrocytes and kills oligodendrocytes, causing characteristic lesions and sites of demyelination.
Describe BK virus
BK virus is ubiquitous and is not associated with serious disease.
Modes of control for papovaviridae
None
Skin warts: Plantar warts
1
Skin warts: Common warts
2,4
Skin warts: flat warts
3,10
Skin warts:
Epidermodysplasia verruciformis
5,8,17,20,36
Benign head and neck tumors:
Laryngeal papilloma
6,11
Benign head and neck tumors:
Oral papilloma
6,11
Benign head and neck tumors:
Conjunctival papilloma
11
Anogenital wart:
Condyloma acuminatum
6,11
Cervical intraepithelial neoplasia, cancer
16,18
Viruses under this and diseases
Papillomavirus - warts
Polyomavirua:
-BK virus - renal disease
-JC virus - Progressive multifocal leukoencephalopathy
Common warts other name
Verruca vulgaris.
Occurs in fingers, hands, feet, and face.
Plantar warts other name
Verruca plantaris
Flat warts other name
Verruca lanta.
Autoinoculation from trauma, such as shaving, is a common means of viral spread.
Cytology detects
Koilocytotic cells
Method of choice for papillomavirus
In situ DNA probe analysis,
Polymerase chain reaction
Describe koilocytosis
Also called vacuolated cytoplasm.
Perinuclear cytoplasmic vacuolization.
Capsid virus is
Resistant to inactivation
