Adenoviridae

Question 1

Describe adenoviridae more

Answer 1

Virus encodes proteins to promote mRNA and DNA synthesis, including its own DNA polymerase.

Question 2

Describe adenoviridae

Answer 2

Naked icosadeltahedral capsid has fibers (viral attachment proteins) at vertices.
Linear double stranded DNA.

Question 3

Virus is spread by

Answer 3

Aerosol, close contact, or fecal-oral to establish pharyngeal infection. Fingers spread virus to eyes.

Question 4

Adenovirus pathology

Answer 4

Virus infects mucoepithelial cells in the respiratory tract, GI tract,and conjunctiva or cornea, causing cell damage directly.
Virus persists in lymphoid tissue (e.g. Tonsils, adenoids, Peyer’s patches)

Question 5

Capsid virus is

Answer 5

Resistant to inactivation by GI tract and drying

Question 6

Modes of control for adenoviridae

Answer 6

Live vaccine for serotypes 4 and 7 is available for military use

Question 7

Adenovirus causes

Answer 7

Adenovirus conjunctivitis

Question 8

Histological appearance of adenovirus-infected cells

Answer 8

Inefficient assembly of virions yield dark basophilic nuclear inclusion bodies containing DNA, proteins, and capsids.