Papillomaviridae Flashcards
properties of papilloma
non enveloped
spherical
icosahedral symmetry
True or False: papillomaviruses are resistant to extreme conditions such as lipid solvents, low pH, and high temperatures
true
what are papillomaviruses able to do to cultured cells?
able to transform cultured cells
describe the warts produced by papillomaviruses
benign neoplasms, hyperplasia epithelial out growths that regress spontaneously
species specific
occasionally may progress to be malignant
what cells of the epithelium does the virus infect first
keratinocytes in the basal layer of epithelium that becomes exposed through micro wounds
what layer is virus accumulation and associated cytopathology most noticeable in?
stratum granulosum
from where are the virions shed?
upper most layer of epithelium
difference between benign and malignant papillomavirus dna
Benign: episomal- not integrated into host cell DNA
Malignant: integrated into hist
which age has highest incidence of bovine papillomatosis
calves and yearlings
transmission of bovine papillomatosis
contaminated fomites (milking equipment, halters) sexual transmission of venereal warts
Name and describe the lesions sometimes caused by bovine papillomatosis
Fibro papilloma caused by types 1,2 and 5 firm, gray-black, cauliflower like spiny and rough UDDER AND TEAT, head, neck, shoulders, omasum, genitals
Cutaneous Papilloma
Bovine papillomatosis
type 3
lack fibrous core
flat, broad base
which plant can cause bovine papillomatosis to become cancerous
Bracken fern
diagnosis for bovine papillomavirus
TEM, PCR, DNA hybridization assay
canine oral papillomavirus clinical signs
(lesions regress spontaneously)
halitosis, hemorrhage, hypersalivation
2’ bacterial infections may occur
ocular warts
