FINAL EXAM- SPRING 17 Flashcards
smallest virus
porcine circovirus type 1
largest virus
poxvirus
shape of ebola virus
filament shaped
shape of rabies virus
bullet shaped
shape of tobacco mosaic virus
rod shaped
shape of pox virus
brick shaped
shape of rotavirus
spherical shape
the ability of a virus to alter its shape or size is called
pleomorphism
what are the four common methods used to determine the morphology of viruses
electron microscopy
cryo electron microscopy
X-ray crystallography
NMR: nuclear magnetic resonance
__________: the protein shell of a virus that in cases or envelopes the viral nucleic acid
capsid
what is the basic subunit protein in the capsid of a virus
capsomere
which type of viruses have a double-layered capsid
reoviruses
symmetry of a parvovirus
simple icosahedron
60 copies of CP protein
T=1
what is the symmetry of Reoviridae
icosahedral
2 capsids:
outer T = 13
inner T = 2
pox virus symmetry
complex symmetry
what are the 8 functions of the viral capsid
1) responsible for the structural symmetry of the virus particle
2) encases and protects the viral nucleic acid from enzymes (nucleases), chemicals, and physical conditions (such as PH and temperature)
3) receptor attachment proteins on the viral capsid facility the attachment of virus to specific receptors on the susceptible host cells
4) interaction with host cell membranes to form envelope
5) uncoating of the genome in host cell
6) transport of the viral genome to the appropriate site
7) packaging of the nucleic acid genome
8) determine antigenicity of the virus
a lipid bilayer with embedded proteins is a(n)
envelope
how is the virus envelope acquired
the envelope is acquired by budding of viral nucleocapsid through cellular membrane:
such as a cytoplasmic membrane, Golgi membrane or nucleus membrane
name the two kinds of viral proteins primarily found in the envelope
- glycoprotein
2. matrix protein
name the two types of virus envelope glycoproteins
external glycoproteins and channel proteins
proteins which are usually the Major antigens of the virus and involved in functions such as haemagglutination, receptor binding, antigenicity, and the membrane Fusion
external glycoproteins
channel proteins
mostly hydrophobic proteins that form a protein lined channel through the envelope (ex ion channel)
This protein alters permeability of the membrane example ion channels.
Such Proteins are important in modifying the internal environment of the virus.
virus envelope matrix protein
- these proteins link the internal nucleocapsid to the lipid membrane envelope
- play a crucial role in virus assembly
- allowed stabilization of the lipid envelope
_________: serves as the recognition site of the nucleocapsid at the plasma membrane and mediates the encapsidation of the RNA nuclear protein cores into the membrane envelope
virus envelope matrix protein
