FINAL EXAM- SPRING 17

Question 1

smallest virus

Answer 1

porcine circovirus type 1

Question 2

largest virus

Answer 2

poxvirus

Question 3

shape of ebola virus

Answer 3

filament shaped

Question 4

shape of rabies virus

Answer 4

bullet shaped

Question 5

shape of tobacco mosaic virus

Answer 5

rod shaped

Question 6

shape of pox virus

Answer 6

brick shaped

Question 7

shape of rotavirus

Answer 7

spherical shape

Question 8

the ability of a virus to alter its shape or size is called

Answer 8

pleomorphism

Question 9

what are the four common methods used to determine the morphology of viruses

Answer 9

electron microscopy
cryo electron microscopy
X-ray crystallography
NMR: nuclear magnetic resonance

Question 10

__________: the protein shell of a virus that in cases or envelopes the viral nucleic acid

Answer 10

capsid

Question 11

what is the basic subunit protein in the capsid of a virus

Answer 11

capsomere

Question 12

which type of viruses have a double-layered capsid

Answer 12

reoviruses

Question 13

symmetry of a parvovirus

Answer 13

simple icosahedron

60 copies of CP protein
T=1

Question 14

what is the symmetry of Reoviridae

Answer 14

icosahedral

2 capsids:
outer T = 13
inner T = 2

Question 15

pox virus symmetry

Answer 15

complex symmetry

Question 16

what are the 8 functions of the viral capsid

Answer 16

1) responsible for the structural symmetry of the virus particle
2) encases and protects the viral nucleic acid from enzymes (nucleases), chemicals, and physical conditions (such as PH and temperature)
3) receptor attachment proteins on the viral capsid facility the attachment of virus to specific receptors on the susceptible host cells
4) interaction with host cell membranes to form envelope
5) uncoating of the genome in host cell
6) transport of the viral genome to the appropriate site
7) packaging of the nucleic acid genome
8) determine antigenicity of the virus

Question 17

a lipid bilayer with embedded proteins is a(n)

Answer 17

envelope

Question 18

how is the virus envelope acquired

Answer 18

the envelope is acquired by budding of viral nucleocapsid through cellular membrane:

such as a cytoplasmic membrane, Golgi membrane or nucleus membrane

Question 19

name the two kinds of viral proteins primarily found in the envelope

Answer 19

1. glycoprotein

2. matrix protein

Question 20

name the two types of virus envelope glycoproteins

Answer 20

external glycoproteins and channel proteins

Question 21

proteins which are usually the Major antigens of the virus and involved in functions such as haemagglutination, receptor binding, antigenicity, and the membrane Fusion

Answer 21

external glycoproteins

Question 22

channel proteins

Answer 22

mostly hydrophobic proteins that form a protein lined channel through the envelope (ex ion channel)

This protein alters permeability of the membrane example ion channels.

Such Proteins are important in modifying the internal environment of the virus.

Question 23

virus envelope matrix protein

Answer 23

• these proteins link the internal nucleocapsid to the lipid membrane envelope
• play a crucial role in virus assembly
• allowed stabilization of the lipid envelope

Question 24

_________: serves as the recognition site of the nucleocapsid at the plasma membrane and mediates the encapsidation of the RNA nuclear protein cores into the membrane envelope

Answer 24

virus envelope matrix protein