Papers Flashcards
What does Dumotier et al. 2014 Heart discuss?
DAD
EAD
Altered Automaticity
Re-entry arrythmias
Scott et al. 2010 Circulation
AKAPs and their sites of action including Yotiao and AKAP15/18a
Why would chronic b-adrenergic signalling be a bad thing in HF?
because chronic stimulation facilitates the issues in heart failure -> b-stimulation can lead to myocyte death although the sympathetic drive is initially helpful through EPAC signalling Zhang et al. 2013 Circ. Res.
What are re-entry arrhythmias self-propagating properties determined by?
cardiac wavelength - short wavelength = re-entry
Dumotier et al. 2014 Heart
What did Zhang et al. 2013 look at?
- why b-adrenergic stimulation is bad after longer periods of time. initially protective through EPAC via CAMKII
- need for b-blockers following MI
- PKI inhibits PKA dependent pathways to myocyte death better than b-blockers
What journal was Zhange et al. 2013 in?
circulation research
What did Bourque et al 2011 Am J Physi look at?
interactions between NO and ET1
NO limits ET1 interaction with it receptor
NO inhibits ET-1 through cGMP
What journal were Bourque et al 2011 found in?
Am J of Physiology
What did Deanfield et al 2007 Circ Res. look at?
NO and the role of NO in endothelial dysfunction
also look at methods comparing flow mediated dilation and coronary risk factors
What year was Deanfield et al, Circ Res?
2007
What did Khan et al. 2008 look at?
NO bioavailability in the microcirculation
What did Flammer et al. 2012 Circulation look at?
method of NO bioavailability and their pros and cons
importance in diagnostics
Furchgott et al. 1980 Nature?
ACh in rabbit arteries with damaged endothelium
Ignarro et al. 1989 Circulation Research
NO is EDRF
EDRF and NO increase cGMP
EDRF and NO have similar spectophotometric outcomes
Vallance et al. 1989
L-NMMA blocks NOS and which is restored with L-Arginine
Bers Nature 2002
EC coupling review
Monte et al. 2001 Circulation?
heart SERCA gene therapy in rats
O’Rourke et al 1999 Circ Research
dog myocardium with CPA - showed SERCA to be blocked in failing compared to non-failing
Chen et al 2007 PNAS
Yotiao S1570L mutation in LQT
Gomez et al. 2011 Science
rat calcium sparks - slower trigger calcium but sparks are indistinguishable but less of them
could be fixed with adrenaline in hypertrophic heart but not HF
Scott et al 2010 Circulation
discussion of AKAPs
