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PATOLOJİ > PANKREAS > Flashcards

PANKREAS Flashcards

1
Q

Tip 1 otoimmun diyabetle ilişkili genler?

A

HLA DR 3
DR 4
DQ 8

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2
Q

Herediter pankreatitte en sık saptanan genetik değişiklikler?

A

PRSS1 (en sık)
SPİNK 1
CFTR

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3
Q

Beta adacık hücre hiperplazisi (nesidioblastozis) görülen sendrom?

A

Beckwith wiedemann

*pankreas adenoCA için risk faktörü değildir.

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4
Q

Pankreas karsinomu riskinin arttığı herediter sendromlar ve genleri?

A

1) Peutz-Jeghers (STK11)
2) Herediter pankreatitler (PRSS1,SPİNK1,CFTR)
3) Ailevi Atipik Multiple Melanom Sendromu= FAMMS Sendromu (CDKN2A)
4) Herediter Meme-Over Kanseri Sendromu (BRCA1-2)
5) Herediter Non-polipozis Kolorektal Kanser Sendromu (MLH1,MSH2)

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5
Q

Pankreas adenokarsinomlarında görülen mutasyonlar?

A

KRAS
CDKN 2A (p16)
SMAD 4
p53 (en sık TumorSuppGen)

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6
Q

Pankreas agenezisi geni?

A

PDX 1

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7
Q

Pankreas konjenital kistleri?

A

OD PKBH
VHL

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PATOLOJİ (17 decks)

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