Pancreatitis Flashcards
1
Q
Acute risk factors
A
Alcohol Gallstones Infection Drugs Metabolic Post ERCP Ischaemia Pancreas Divisum
2
Q
Chronic risk factors
A
Alcohol Genetic causes Duct Obstruction Tropical infection Systemic disease Autoimmune Mitholithiasis Previous pancreatitis Smoking
3
Q
Inherited pancreatitis
A
Hereditary pancreatitis:
- AD 80% penetrance
- Recurrent mild attacks from 5yrs old
- Chromosome 7 - PRSS1
- High trypsin –> pancreatitis
- High risk of pancreatic cancer
SPINK1 mutation
- Adolescents with chronic pancreatitis
- Normal trypsin
CFTR mutations
4
Q
Autoimmune pancreatitis
A
IgG4 disease
Mild recurrent attacks
Raised IgG4
Associated with sjogrens syndrome, PBC and RA
Treat with steroids
5
Q
? early surgery for necrotizing pancreatitis
A
Wait until cysts are mature
6
Q
ABCB4 Disease
A
Codes for multidrug resistance protein 3
Helps excrete bile into ducts
Cause of several biliary tract diseases
- Cholestasis of pregnancy
- Progressive familial intrahepatic cholestasis
- Recurrent pancreatitis
Nil treatment
7
Q
Treatment of pancreatitis improving patient outcomes?
A
Aggressive fluid replacement and supportive care
