Duodenal disease Flashcards
1
Q
Causes of malabsorption?
A
Enzyme deficiency
Bacterial overgrowth
Coeliac disease
Lymphangectasia
2
Q
Causes of Vitamin B12 deficiency
A
Vegan diet Pernicious anaemia Atrophic gastritis Gastrectomy Bacterial overgrowth Pancreatic insufficiency Crohn's disease
3
Q
Coeliac disease
Pathophysiology
A
T cell mediated disease
Formation of antibodies against gliadin
- ->
- Villious atrophy
- Lymphocyte infiltration
–> malabsorption
4
Q
Coeliac disease associations
A
Dermatitis herpetiformins
Autoimmune conditions
- Type 1 DM
- Hypothyroidism
- IgA deficiency
Down syndrome
Turners syndrome
LIVER DISEASE
5
Q
Coeliac serology
A
Most sensitive test = Tissue transglutaminase antibody
Others:
- Anti gliadin antibodies
- Endomysial antibodies
- Deamidated anti gliadin antibodies
STILL REQUIRES HISTOLOGY FOR DIAGNOSIS
6
Q
Which vitamin/mineral is most likely to be deficient in a patient with coeliac disease?
A
Iron
