Pancreatitis Flashcards

1
Q

What is the difference per definition between acute and chronic pancreatiis

A

acute - completely reversible after romoval of the inciting cause

chronic - irreversible histopath changes

differences - mostly histopathological, not necessarily clinical

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2
Q

What is the most common “cause” for pancreatitis in cats?

A

> 95% idiopathic, without specific cause identified

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3
Q

Which digestive enzyme is autoactivated in pancreatitis as the inciting cause?

A

trypsinogen

not implicated in chronic panc, just acute

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4
Q

List implicated causes for acute pancreatitis in cats

A
  • autoactivation of trypsinogen
  • thrombin activating zymogens
  • sepsis/SIRS - systemic inflammation and NFkappaB pathways
  • alterations in Ca++ signaling –> colonization of lysosomes and zymogens granules + trypsinogen activation
  • hypoperfusion and thrombosis
  • bile acid and trypsin reflux
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5
Q

How does the echogenicity of a normal pancreas compare to the liver?

A

normal pancreas - similar echogenicity (isoechoic or hypoechoic compared to surrounding mesentery)

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6
Q

Which lob of the feline pancreas is larger?

A

left

right - small and difficult to find

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7
Q

What is the sensitivity of AUS to detect acute pancreatitis in cats?

A

wide range reported - 11-67% - depends on severity and operator

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8
Q

How accurate is fPLI for the diagnosis of pancreatitis in cats?

A
  • sensitive to detect pancreatitis
  • less specific

i.e., normal results make pancreatitis unlikely

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