GI/Pancreas Flashcards
1
Q
What is the difference between dog’s and cat’s esophagus?
A
Dog: 100% striated muscle
Cat: only upper 2/3 are striated muscle, the rest 1/3 is smooth muscle
2
Q
What can cause the resting membrane potential less negative (more easily excitable) in GI tract? What can cause it to be more negative (harder to depolarize)?
A
Less negative
- stretch of the smooth muscle
- stimulation by acetylcholine released from the endings of parasympathetic nerves
- stimulation by several specific gastrointestinal hormones
More negative
- catecholamines
- stimulation of sympathetic nerves
3
Q
What are the enteric nerve system composed of? And what are their functions?
A
Myenteric plexus - control the GI movement
Submucosal plexus - control the local blood flow and GI secretion
4
Q
List 5 different enteric neurotransmitter/hormone substances
A
Substance P
Vasoactive intestinal peptide
Acetylcholine
Dopamine
Cholecystokinin
Somatostatin
Adenosine triphosphate
Norepinephrine
Serotonin
Nitric oxide
5
Q
Which parts of the GI system dose vagus nerve innervated?
A
esophagus, stomach, small intestines, pancreas, first half of the large intestines
- The second half of large intestines and anus are innervated by pelvic nerves
6
Q
Where is cholecystokinin secreted and what are its functions?
A
I cells of the duodenum, jejunum and ileum
It stimulates pancreatic enzymes and bicarb secretion, GB contractions, and inhibits gastric emptying
7
Q
Where is gastrin secreted and what are its functions?
A
G cells in the gastric antrum
It stimulates gastric acid secretion and growth of the gastric mucosa
8
Q
Where is motilin secreted and what is its functions?
A
M cells of stomach and upper duodenum during fasting
It increases GI motility
9
Q
Why are the GI villi vulnerable to ischemia?
A
Because of the countercurrent blood flow of the arterioles and venules in the villi.
Most of the oxygenated blood (~80%) diffused from the arterioles to the venules without reaching the tip of the villi.
10
Q
Fill out the blank about the gastric secretion.
A
11
Q
True or False: Pepsinogen in the stomach can only become active in acidic environment.
A
True
Under acidic environment, pepsinogen is activated to form active pepsin and has proteolytic effect.
12
Q
How does the body control gastric acid secretion?
A
Food goes down to antral end of the stomach → stimulates G cells secrete gastrin → gastrin reach the ECL cells in the oxyntic glands (gastric glands) → stimulates histamine release →histamine stimulate parietal cells secrete HCl
13
Q
What are the pancreatic enzymes for proteins, carbohydrates and fat digestion?
A
Proteins: trypsin, chymotrypsin, carboxypolypeptidase
Carbohydrates: pancreatic amylase
Fat: pancreatic lipase, cholesterol esterases, phospholipase
14
Q
What is the enzyme that activates the trypsinogen?
A
Enterokinase (secretes by the intestinal mucosa)
15
Q
How does pancreas prevent self-digestive under normal condition?
A
The pancreatic cells that secrete proteolytic enzymes also secrete trypsin inhibitor at the same time to prevent activation of trypsin inside the pancreas
16
Q
What are the three basic stimuli for pancreatic secretion?
A
Acetlycholine
Cholecystokinin
Secretin (make pancreas secretes lots of water and bicarbs by pancreatic duct epithelium)
17
Q
True or False: only 50% of bile salts undergo enterohepatic circulation.
A
False
94% of bile salts go through enterohepatic circulation.
18
Q
List the compositions of the bile
A
Water
Bile salt
Bilirubin
Cholesterol
Bicarb
Electrolytes
Fatty acids
Lecithin
19
Q
What is the precursor of bile salt?
A
Cholesterol
20
Q
What is the life span of an intestinal epithelial cell?
A
2-5 days
21
Q
Where does the vomiting center locate?
A
Medulla oblongata of the brainstem
22
Q
Where does the chemoreceptor trigger zone locate?
A
Area postrema of the floor of 4th ventricles (no BBB)
23
Q
What is the difference in the pathway of vestibular-induced vomiting between dogs and cats?
A
In dogs, the signal transmits from the vestibular system to the CRTZ zone and then to the vomiting center; in cats, the signal directly transmits from the vestibular system to the vomiting center
24
Q
How can you determine intestinal dilation via x-rays in dogs and cats?
A
Dogs: diameter of the small intestine should be less than 1.6x of the height of L5 vertebral body at its narrowest point.
Cats: no bigger than 12mm or less than 2x of the height of L4 vertebral body
25
Where do enterochromaffin cells locate and what do they do?
They locate in small intestines and secrete serotonin (5-HT) in response to mechanical or chemical stimuli → regulates intestinal secretion and motility
26
What is the MOA of maropitant?
Neurokinin-1 (NK-1) receptor antagonist
It blocks the substance P to the NK-1 receptors in the CNS and GI tract.
27
What is MOA of ondansetron?
Selective 5HT-3 receptor antagonist
It blocks CRTZ and vagal nerve endings in the GI tract.
* The serotonin receptor in the vomiting center is 5HT-1
28
What is the MOA of metoclopramide?
D2 antagonist (CRTZ zone), 5HT-3 antagonist (mild), 5HT-4 agonist (for the prokinetic effect)
29
What is the proposed pathophysiology of extrapyramidal effect from metoclopramide?
A striatal D2 receptor blockade
Clinical signs: involuntary or uncontrollable movements. tremors. muscle contractions
Treatment: d/c metoclopramide, give antihistamine/anticholinergic drugs
30
What is the MOA of cisapride?
5HT-4 agonist →Increases acetylcholine at the myenteric plexus
31
What is the MOA of erythromycin for its prokinetic effect?
Motilin receptor agonists
Works for canine colon motility but not feline
32
What is the MOA of omeprazole and pantoprazole?
Proton-pump inhibitor (PPI) → irreversibly inhibits the H+/K+ ATP pumps in the gastric gland
33
What is MOA of sucralfate
1) antipeptic effect - absorb pepsin
2) form a barrier at the mucosal surface
3) increases mucus viscosity
34
For dogs with GDV, which arteries are most commonly lacerated and lead to hemoabdomen?
Short gastric arteries
35
Name the vessels.
1. Splenic artery
2. Short gastric arteries
3. Lt. gastroepiploic artery
4. Lt. gastric artery
5. Rt. gastric artery
6. Celiac artery
36
What are the 5 types of techniques for gastropexy?
1. Incisional
2. Belt-loop
3. Circumcostal
4. G-tube placement
5. Gastrocolopexy
6. Endoscopy assisted
37
What is the key component of successful gastropexy?
Make sure the incisions on the gastric serosa and peritoneal wall both reach the muscular surface.
38
Describe how to perform an incisional gastropexy.
1. Make a midline incision on the ventral abdomen and enter the abdomen.
2. Identify the gastric antrum and where it is expected to joint on the peritoneum, which should be right lateral or right ventral lateral peritoneum which is 2-3 cm caudal to the last rib.
3. Make a 4 cm seromuscular incision at the gastric antrum either parallel or perpendicular to the gastric long axis
4. Make a second 4cm incision on the peritoneum and transversus abdominis muscle.
5. Appose both incisions with 2-0 monofilament absorbable sutures in a simple continuous suture pattern, beginning with the craniodorsal edge of the incision
6. Close the abdomen
39
Describe esophagostomy tube placement.
1. Patient is anesthetized and endotracheally intubated, and positioned in right lateral recumbency.
2. The left cervical area is clipped and surgically prepped.
3. The operator measures the esophagostomy tube from the left mid cervical area to the 7-9th intercostal space and make a mark on the tube.
4. The assistant inserts a Carmalt forceps from oral cavity into the esophagus until the tip reaches the mid cervical esophagus, and the assistant tents skin with the tip of forceps
5. The operator (with sterile gloves) use a #10 or #11 scalpel blade to make a incision through the skin, connective tissue and esophageal wall so that the tip of the forceps can push through
6. Place the esophagostomy tube in between the forceps tip and allow the forceps to hold the end of the tube.
7. Pull the tube back to the oral cavity with the forceps and then re-insert the tube into the esophagus. At the same time gently manipulate the other end of the tube to facilitate the placement.
8. Once the entire to is in the esophagus, the direction of the part of the tube that exit the left mid cervical esophagus will flip from caudal to cranial. Make sure the tube is inserted to the pre-measured depth
9. Place a purse-string suture around the tube entrance on the left cervical area.
10. Place a finger trap suture at the base of the tube at where it enters the skin to secure it.
11. Take x-rays to confirm tube placement.
40
Describe the NG tube placement.
1. Apply proparacaine into the nostril 15 min prior to tube placement.
2. Measure the NG tube from the tip of the nose till the last rib.
3. flush the NG tube with saline and apply lubricant on the tube
4. Keep patient's head in natural position. Insert the NG tube into the nostril at medial-ventral direction. Assist the tube insertion direction by pushing the nose dorsally (piggy-nose).
5. Once the tube reach the pre-measured mark. Remove the stylet. Secure the tube with suture or tape and staples.
6. Take x-rays from the nose to the stomach to confirm tube placement.
41
After a gastrotomy tube is placed, how long should you wait until you can feed the animal and why?
12-24 hours; have to wait for fibrin formation to seal the stoma
* A permanent stoma will form in 7-14 days
42
What is Cullen's sign?
Periumbilical ecchymosis → usually associated with peritoneal or retroperitoneal hemorrhage
43
During abdominocentesis, which patient position is the most ideal position to avoid puncture of the spleen?
Left lateral recumbency
44
Describe diagnostic peritoneal lavage
1. Position the patient in left lateral recumbency.
2. Surgically clip and clean the midline. Insert a catheter and remove the stylet. Attach a syringe to the catheter
3. Insert 22ml/kg warm sterile normal saline in a drip set into the abdomen.
4. Gentle massage and rotate the patient.
5. Aspirate the fluid back from the syringe
45
In the study published by Zacher et al in 2010 about lactate measurement in patients with GDV, what kind of changes in lactate were associated with better survival and fewer complications?
Initial lactate < 4 mmol/L and/or > 40% reduction after fluid resuscitation
Reference: Zacher LA, Berg J, Shaw SP, Kudej RK. Association between outcome and changes in plasma lactate concentration during presurgical treatment in dogs with gastric dilatation-volvulus: 64 cases (2002-2008). J Am Vet Med Assoc. 2010;236(8):892-897.
46
What are the examples of protein-losing enteropathy?
Eosinophilic bowel disease
Lymphocytic-plasmacytic bowel disease
Lymphangiectasia
Diffuse intestinal fungal disease
Intestinal neoplasia
47
How do NSAIDs cause GI ulcer & GI bleed?
NSAIDs inhibit COX pathway, and therefore inhibit biosynthesis of prostaglandins from AA. Prostaglandins protect upper GI from mucosal damage (by inhibit gastric acid secretion, stimulate mucus and bicarb secretion)
48
True or False: The canine esophagus is comprised almost exclusively of striated muscle, so metoclopramide and cisapride have no beneficial effect.
True
Metoclopramide and cisapride are smooth muscle prokinetic agents
49
What type of virus is parvovirus (DNA vs RNA; enveloped vs non-enveloped)?
non-enveloped DNA virus
50
True or False: Patients with septic peritonitis and has persistent ionized hypocalcemia during hospitalization was associated with poor prognosis
True (CCM textbook)
51
What are the predictive values for glucose and lactate in the diagnosis of bacterial peritonitis
Blood glucose is at least 20 mg/dL higher than abdominal effusion glucose
Blood lactate is at least 2.0 mmol/L lower than abdominal effusion glucose
52
What are the poor prognosis indicators for septic peritonitis?
Refractory hypotension, DIC, respiratory diseases, cardiovascular collapse
Cats: hypothermia and bradycardia
53
When a blind needle paracentesis is performed, what is the minimal amount of fluid required for the result to be positive?
5.2 - 6.6 ml/kg
54
When a peritoneal dialysis catheter is used for abdominocentesis, what is the minimal amount of fluid required for the result to be positive?
1.0 - 4.4 ml/kg
55
Why is BUN less reliable in the diagnosis of uroabdomen?
BUN can easily move across between the peritoneum and blood vessels
56
What are the diagnostic criteria for uroabdomen in dogs and cats?
Dogs:
- Abdominal effusion creatinine is 2 times higher than plasma creatinine
- Abdominal effusion K is 1.4 times higher than plasma creatinine
Cats:
- Abdominal effusion creatinine is 2 times higher than plasma creatinine
- Abdominal effusion K is 1.9 times higher than plasma creatinine
57
Where do H2 blockers work on?
Gastric parietal cells
58
Rank the potency of the following H2 blockers from the most the least:
cimentidine, ranitidine, nizatidine, famotidine
Famotidine > Nizatidine > Ranitidine = Cimentidine
59
Which of the following H2 blocker does not go through first-pass hepatic metabolism?
cimentidine, ranitidine, nizatidine, famotidine
Nizatidine
60
Which of the following H2 blocker absorption is delayed by food?
cimentidine, ranitidine, nizatidine, famotidine
Cimentidine
61
True or False: Ranitidine is excreted in the urine and famotidine is metabolized by liver.
False
Ranitidine is metabolized by liver and famotidine is excreted in the urine
62
Which of the following H2 blocker is shown to inhibit hepatic P-450 enzyme and can be used to lessen the severity of acetaminophen toxicity?
cimentidine, ranitidine, nizatidine, famotidine
Cimentidine
63
What is the special instruction for omeprazole administration to maximize its effect? What is the reason behind that?
Give it on an empty stomach
Maximize the acidity of the gastric parietal cell so more omeprazole can be sequestrated there
64
Which PPI inhibits hepatic P-450 enzymes?
Pantoprazole, omeprazole, lansoprazole, esomeprazole
Omeprazole
65
What is the MOA of misoprostol? What does it do?
Prostaglandin E1 analog
Antacid, GI mucosal protectant (it stimulates secretion of mucus and bicarbonate and increases gastric mucosal blood flow)
66
How is metoclopramide being metabolized?
Excreted via kidneys
67
How does promazine derivatives exhibit their antiemetic effect?
Antidopaminergic, alpha adrenergic antagonist, antihistaminic, anticholinergic, antispasmodic
68
What is the MOA of bethanechol?
Cholinomimetic drug
Acts on the M1 parasympathetic receptors of the gastric parietal cells
69
In a recent study published by Grange et al., how many percentage of patients with GDV has concurrent aspiration pneumonia?
14%
Reference: Grange AM, Clough W, Casale SA: Evaluation of splenectomy as a risk
factor for gastric dilatation-volvulus, J Am Vet Med Assoc 241(4):461-466,
2012.
70
Which part of the stomach is most likely to develop gastric necrosis in GDV?
Gastric fundus
71
What is the definition and common causes of transudate, modified transudate, and exudate?
Transudate
- TP < 2.5 g/dL
- cell count < 500 cells/uL
- cause: hypoalbuminemia, low oncotic pressure
Modified transudate
- TP > 2.5 g/dL but < 5.0 g/dL
- cell count > 300 but < 5500 cells/uL
- causes: passive congestion of the liver (e.g. right-sided CHF), lymphatic drainage obstruction
Exudate
- TP > 5.0 g/dL
- cell count > 5000-7000 cells/uL
- causes: any kind of peritonitis
72
How do you diagnose Giardia spp?
Zinc fecal flotation
73
What are the predominant parvovirus strains in the USA?
CPV 2b & CPV 2c
74
What does IDEXX Canine Parvo SNAP kit test for (antigen/antibody)?
ELISA, test for parvovirus antigen
75
In parvoviral enteritis, what kind of findings on the CBC are associated with better survival?
Degenerative left shift, lymphocytosis, monocytosis
* monitoring the monocyte count in the blood is beneficial in evaluating the recovery from a leukopenic state in patients suffering from CPV enteritis (it takes shorter time to produce monocytes than neutrophils; 3 days vs 6 days)
Reference: Goddard, A et al. “Prognostic usefulness of blood leukocyte changes in canine parvoviral enteritis.” Journal of veterinary internal medicine vol. 22,2 (2008): 309-16.
76
In a recent study published by Chalifaux, what are the negative prognostic indicators for parvoviral enteritis?
Lower BG, higher total Mg, lower HCT on presentation
* Leukopenia, number of band cells are not associated with outcome in this study
Reference: Chalifoux, Nolan V et al. “Prognostic indicators at presentation for canine parvoviral enteritis: 322 cases (2001-2018).” Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) vol. 31,3 (2021): 402-413.
77
Does modified live parvo vaccine interfere with the Parvo SNAP test result?
No
Reference: Schultz RD, Larson LJ and Lorentzen LP. Effects of Modified Live Canine Parvovirus Vaccine on the SNAP ELISA Antigen Assay. Veterinary Emergency and Critical Care Society 2008.
78
How do you disinfect the surface that is exposed with parvo?
Diluted bleach (1:30) and leave it at the surface for at least 10 minutes
79
What kind of bacteria is Clostridium perfringens?
Gram (+), anaerobic bacillus
80
What is the difference in cholesterol level between PLE and PLN?
Cholesterol level is high in PLN but low in PLE
81
In dogs with PLE, what is the proposed cause for ionized hypocalcemia?
Decreased GI vitamin D absorption
82
What is the predisposed breed for mesenteric torsion?
German shepherd (usually young, like 2-4 yrs)
83
What is the difference of the pancreatic duct anatomy between the dogs and cats?
Dogs: pancreatic duct usually doesn't join the common bile duct before entering the duodenum, there is a second small pancreatic duct entering the duodenum separately
Cats: pancreatic duct usually join the common bile duct before entering the duodenum
84
What is the major biotype of Clostridium perfringens?
Type A
85
What kind of bacteria is Samonella spp (e.g. gram positive/negative, aerobic/anaerobic, spore-forming or not)?
Gram negative, motile, non-spore forming, facultative anaerobic bacilli
family Enterobacteriaceae
86
What kind of bacteria is Campylobacter spp (e.g. gram positive/negative, aerobic/anaerobic, spore-forming or not)?
Gram negative, microaerophilic, motile, curved rods
87
Is Escherichia coli a normal GI flora in dogs and cats?
Yes
88
What are the 7 pathotypes of E coli?
Enteropathogenic E. coli (EPEC)
Enterotoxigenic E. coli (ETEC)
Enterohemorrhagic E. coli (EHEC)
Necrotoxi- genic E. coli (NTEC)
Enteroinvasive E. coli (EIEC)
Enteroaggregrative E. coli (EAEC)
Adherent-invasive E. coli (AIEC) strains
Reference: Marks SL, Rankin SC, Byrne BA, Weese JS. Enteropathogenic bacteria in dogs and cats: Diagnosis, epidemiology, treatment, and control. J Vet Intern Med 2011; 25:1195-1208.
89
What is the recommended treatment for boxer granulomatous colitis?
Enrofloxacin 10 mg/kg q24h for 8 weeks
90
According to the ACVIM consensus statement of pancreatitis in cats, what are the proposed mechanism of spontaneous pancreahtits?
1) auto-activation of cationic trypsinogen (more likely when pH ≥5.0)
2) activation of zymogens by thrombin during bacterial toxemia, ischemia, or hypoxia
3) co-localization of lysosomal proteases and zymogen granules (because of an apical block of zymogen granule secretion)
4) activation of trypsinogen by cathepsin B
5) enterokinase entering the portal circulation after a meal in conjunction with biliary-pancreatic reflux
91
True or False: Hypertriglyceride is a common finding in feline pancreatitis.
False
It's actually rare in feline pancreatitis
Reference: ACVIM consensus statement of feline pancreatitis
92
Which electrolyte abnormality has been associated with poor outcome in feline acute pancreatitis?
ionized hypocalcemia
* Other poor prognostic indicators include hypoglycemia and azotemia
93
What does 5-HT stand for?
5-Hydroxytryptamine, also known as serotonin
94
Where does the majority of the serotonin locate in the body?
GI tract (> 95%; more than 90% in the enterochromaffin cells)
95
What are the different 5-HT receptors in the GI tract and what are their function and drugs work on them?
5-HT1p: initiate peristalsis and secretory reflexes
5-HT3: activates sensory nerves and is responsible for nausea or vomiting from GI irritation/mechanical force
- 5-HT3 antagonist: metoclopramide, ondansetron
5-HT4: increases pre-synaptic release of acetycholine and facilitates propulsive peristaltic and secretory reflexes.
- 5-HT4 agonist: metoclopramide, cisapride (does not cross BBB)
96
How does ranitidine work as prokinetics?
It is an H2 blocker. It can also inhibit acetylcholinesterase → more acetylcholine to bind to smooth muscle muscarinic receptors
*greatest activity at upper GI tract
97
What is the definition of intra-abdominal hypertension?
Pathologic elevation of IAP of more than 12 mmHg
98
What is abdominal perfusion pressure (APP)?
APP = MAP - IAP
99
What is the definition of abdominal compartment syndrome?
Sustained increase in IAP of more than 20 mmHg that is associated with newly developing organ failure or dysfunction
100
What is the grading cutoff and recommended therapy for IAP?
101
According to the World Society of the Abdominal Compartment Syndrome, which way of intra-abdominal pressure measurement is considered gold standard?
Placing the probe in the urinary bladder
102
Describe how to measure IAP with urinary bladder method
1) Place a foley urinary catheter sterilely and inflate the foley. Empty the bladder. Place the patient in lateral recumbency.
2) Attach the urinary catheter to the proximal port of the three-way stopcock. Attach a water manometer to the upright port of the three-way stopcock. Attach a bag of normal saline with IV set to the distal port of the three-way stopcock.
3) Fill the bladder with 0.5-1 ml/kg of normal saline (max is 25ml per patient).
4) Zero the system at the patient's midline at the symphysis pubis.
4) Turn the three-way stopcock away from the patient end and fill the water manometer with normal saline.
5) Turn the three-way stopcock away from the fluid bag and allow the water manometer and the urinary bladder equilibrate.
6) The difference between the reading at the meniscus and the zero point at the end of expiration is the IAP.
103
What is normal IAP in dogs? What about cats?
Dogs: 0-5 cmH2O
Cats: 4-8 cmH2O
104
What is the relationship between glomerular filtration gradient, MAP and IAP?
Filtration gradient = glomerular filtration pressure - proximal tubular pressure = MAP - IAP - IAP = MAP - 2IAP
105
What are the three antioxidant systems and their examples?
1) Antioxidant proteins: albumin, haptoglobin, ceruloplasmin
2) Enzymatic antioxidants: superoxide dismutase, glutathoine peroxidase, catalase
3) Non-emzymatic or small molecules antioxidants: vitamin C, vitamin E, glutathione, selenium
106
Arginine is contraindicated in patients with what diseases? Why?
Severe sepsis
Arginine supplementation will increase nitric oxide production and potentially worsen the cardiovascular tone and tissue perfusion
107
What is the normal enteral protein intake for dogs and cats?
Dogs: 4-6g/100kcal (15-25% of total energy)
Cats: 6g+/100kcal (25-35% of total energy)
108
What are the common electrolytes derangement in refeeding syndrome?
Hypophosphatemia
Hypokalemia
Hypomagnesemia
Hypocalcemia
Hyponatremia
Others: hyperglycemia, thiamine deficiency, vitamin deficiency
109
What is the pathophysiology of refeeding syndrome?
During prolonged starvation/anorexia or certain catabolic state, the intracellular electrolytes are depleted. When the enteral nutritions introduced, the cells start to switch to metabolic states and certain electrolytes (e.g. phosphorus and magnesium) are heavily required as the source or co-factors for the metabolic pathways, which leads to rapid depletion of those extracellular electrolytes.
110
When do clinical signs of refeeding syndrome commonly seen after initiating feeding?
2-5 days
(can range from within hours to up to 10 days)
111
What are the clinical signs for refeeding syndromes?
Muscle weakness, tachyarrhythmias, hemolytic anemia, neurological signs, peripheral edema, respiratory failure
112
True or False: EPA is Omega-6 fatty acid.
False
EPA is one of the Omega-3 fatty acids. An example of Omega-6 fatty acid is AA.
113
What is the kcal/ml of 50% dextrose? What about its osmolality?
1.7 kcal/ml, 2500 mOsm/L
114
How much percentage of calories can be given via lipid in parental nutrition?
50-70%
115
What is the kcal/ml of 20% lipid emulsion?
2 kcal/ml
116
How many kcals does one gram of protein provide?
4 kcal/g
117
What are the recommended dosage for Vitamin B com, Mg, Zinc and potassium?
118
What are the components of Procalamine?
3% amino acids, 3% glycerin and electrolytes
*Concentration for electrolytes(mEq/liter): Sodium 35; Potassium 24.5; Calcium 3; Magnesium 5; Chloride 41; Phosphate (HPO=4) 7
119
How many calories does 1ml of procalamine provide? What is its osmolality?
0.25 kcal/ml
Osmolality: 735 mOsm/L
120
What are the electrolytes changes can cause constipation?
Hypokalemia
Ionized hypomagnesemia
Ionized hypercalcemia
Ionized hypocalcemia
121
What are the drugs that can cause constipation?
Opioids
Sucralfate
Anticholinergics
Diuretics
Barium
Phenothiazines
Antihistamins
Iron
122
What are the drugs that can work as colonic prokinetics and what are their MOAs?
Cisapride - 5-HT4 agonist
Ranitidine - Acetylcholinesterase inhibitor
Erythromycin - Motilin agonist (in vitro)
123
What is the maximal gastric capacity in dogs and cats?
45-90 ml/kg
124
What is the MOA of capromorelin?
ghrelin receptor agonist
Ghrelin is roduced by the parietal cells of the gastric mucosa as an endogenous ligand for growth hormone.
125
What is MOA of mirtazapine as an appetite stimulant in cats?
5-HT2c antagonist
126
What are the osmolality limitation for peripheral route and central route of parenteral nutrition administration?
Peripheral: < 750 mOsm/L
Central: < 1400 mOsm/L
127
What are the substances that excite the GI motor neurons and what inhibit the GI motor neurons?
Excites: acetylcholine, serotonin, substance P
Inhibits: norepinephrine, GABA, NO, vasoactive intestinal peptides (VIP), somatostatin
128
True or False: Both cats and dogs can generate migrating motor complexes (MMC) during the interdigestive phase.
False.
Only dogs generate MMC and it's about 15-20 sec/min. Cats generate giant migrating complex.
129
Describe enterogastric reflex.
When the duodenum detects low PH, high lipid content or high osmolality, it will inhibit the vagus nucleus and activate the sympathetic nerves to inhibit the gastric peristalsis, tighten the pyloric sphincter and delay gastric emptying.
130
What are the three gastrointestinal reflexes?
Enterogastric reflexes
Gastrocolic reflexes
Gastroileal reflexes
131
What are the 5 main contraction patterns for small intestines?
Peristaltic waves
Stationary segmenting contractions
Giant contractions (aboral)
Stationary or migrating clusters of contractions
MMCs
132
What are the average small intestinal transit time in dogs and cats?
Dogs: 3-5 hours
Cats: 2-3 hours
133
What are the two main theories for gastroparesis in critically ill patients?
1) Primary gastric pump failure
2) Excessive feedback theory: nutrients release excessive CCK and serotonin which cause disproportional inhibitory effect from the intestines to the stomach
134
How does inflammation cause intestinal ileus?
The inflammatory mediators can damage the intestinal muscular layer by releasing proteolytic enzymes and cytokines. They can also cause NO release and paralyze the muscular layer which leads to ileus
135
How does opioid cause decreased GI motility?
Opioid binds to the peripheral mu-receptor in the GI system and lead to decreased GI motility. It also inhibits the release of Ach.
136
What are the treatment strategies for GI dismotility?
Early nutrition intervention
Early ambulation
Pain management
Maintain euhydration status
Maintain normothermia
Prokinetics
Address the underlying diseases (e.g. correct electrolyte imbalances)
137
Which serotonin receptors in the GI tract is mainly responsible for peristalsis?
5-HT4
138
Where do the following prokinetics work for the colon?
Metoclopramide
Cisapride
Ranitidine/Nizatidine
Erythromycin/Azithromycin
Ondansetron
Maropitant
Cisapride, Ranitidine/Nizatidine
139
What are the suggested drugs that may be reported to be associated with acute pancreatitis in dogs?
L-asparaginase
Phenobarbital
KBr
Azathioprine
Potentiated sulfonamides
Organophosphates
Corticosteroids
Furosemide
Atovaquone/proguanil (Malarone)
N-methyl-glucamine (Meglumine)
Clomipramine
Zinc
140
What are the endocrinopathies that have been reported as risk factors for AP in dogs?
Hyperadrenorcorticism, hypothyroidism, DM
141
What are the keys of AP pathogenesis?
Premature trypsinogen activation
Activation of nuclear factor- kappa beta (NF-κB)
142
What are the proposed mechanisms for activation of trypsinogen and NF-κB in dogs with AP?
Deranged calcium signaling
Colocalization of zymogens and lysosomes
Oxidative stress
Impared autophagy
Mitochrodrial dysfunction
Endoplasmicreticulum stress
143
Where in the GI tract is bile acid reabsorbed?
Distal ileum by apical Na dependent bile acid transporter (ASBT)
144
Describe how to perform gastrotomy.
1) Make a midline incision and achieve hemostasis with cauterization
2) Isolate the stomach from the remainder of abdomen with moistened laparotomy sponges
3) Place two stay sutures
4) Make an incision at the ventral surface of the stomach between the lesser and greater curvatures (find the area with least vascularity)
5) place the suction tip into the stomach to remove all the gastric fluid
6) Close the stomach with continuous double-layer inverting closure patterns with monofilament absorbable sutures. The first layer incorporates full thickness of stomach wall. The second layer incorporates serosa and muscular layers.
145
In general, inflation pressures higher than _______ are not recommended during laparoscopy
15 mmHg
