Pancreatic Patient Flashcards
Differentials to consider for RUQ/Epigastric Pain
- Gallbladder Disease
- Hepatits
- Pancreatitis
- PUD
Describe the process that occurs in acute pancreatitis
Activation of digestive enzymes, kinases, and inflammatory markers leads to auto digestion of the pancreas.
Results in SAPONIFICATION that leads to hypocalcemia
2 most common causes of acute pancreatitis
Biliary Tract stones
Heavy alcohol use
Other less common causes of acute pancreatitis
Trauma
Medications
Infectious agents (mumps, CMV)
Autoimmune issues
What is a common chief complaint from patient’s presenting with acute pancreatitis?
Constant, boring pain that goes straight through them to their back.
PE findings of acute pancreatitis
Cullen/Gray Turner Sign (ecchymosis)
Chvostek and Trousseau signs (hypocalcemia)
ARDS
Diagnostic criteria for acute pancreatitis
2/3
- Epigastric pain
- 3xULN for Lipase (and amylase)
- CT changes
What would be seen on a CMP in a patient with acute pancreatitis?
Hyperglycemia Hyperbilirubinemia Increased BUN Elevated Creatinine Elevated ALT Hypocalcemia "Harry Herbert's manBUN Created ALTernative Calcium"
What are the 2 XR signs indicative of acute pancreatitis?
Sentinal Loop- air-filled SI in LLQ
Colon cutoff sign- gas filled Transverse colon
What is the first line treatment for acute pancreatitis
Fluid Resuscitation
Complications associated with acute pancreatitis
- 3rd spacing fluid leaks
- Pre-renal azotemia (most common form of kidney failure in hospitalized patients)
- Pleural Effusion
* Dry intravascularly but edema everywhere else; why you need to treat fluids first - Pseudocysts
- ARDS
Ranson Critera for acute pancreatitis severity upon admission
"GA-LAW": 3 or more= severe course with necrosis in 60-80% of patients Glucose>100 Age>55 LDH>350 AST>250 WBC>16,000
Ranson Criteria for acute pancreatitis severity 48hrs after admission
"C & HOBBS" Calcium <8 Hct drop >10% O2 (PaO2) <60mmHg Base deficit >4 BUN increase >5 Sequestration of fluid >6L
BISAP score for acute pancreatitis at or within 24 hrs of admission
Bun>25mg/dL Impaired Mental status SIRS: >2 of 4 Age >60 Pleural Effusion
APACHE II score
Just know higher the score the higher the mortality rate
What is a sign of infected pancreatic necrosis and what are common organisms to cause it?
Emphysematous Pancreatitis
- C. Perfringens
- E. Aerogenes
- E. Faecalis
* Don’t think we need to memorize those but good to know
Describe Chvostek Sign
twitching of facial muscles due to hypocalcemia
Describe Trousseau sign related to hypocalcemia
hand postures when BP cuff is pumped up
Which is a better prognostic indicator of pancreas function, Lipase or Amylase
Lipase: more specific to pancreatitis
What is the most frequent cause of chronic pancreatitis?
Alcoholism
PE findings of chronic pancreatitis
epigastric pain steatorrhea WL Fatigue Pain
Diagnostic labs for chronic pancreatitis
Lipase/Amylase
Steatorrhea
DECREASED FECAL ELASTASE < 100 mcg
What is usually seen on XR in chronic pancreatitis patients
Pancreaticolithiasis
What can be seen on CT that would probe workup for possible pancreatic cancer?
tumefactive chronic pancreatitis (chronic pancreatitis with a mass and/or obstructive jaundice)