18-4: Cholestatic Disease

Question 1

what is cholestasis

Answer 1

a decrease in bile flow due to impaired secretion by hepatocytes or to obstruction of bile flow

Question 2

What is a hallmark of cholestasis

Answer 2

accumulation of green-brown plugs of bile pigment in hepatocytes and dilated canaliculi

Question 3

What is the function of hepatic bile?

Answer 3

emulsify fats

elimination of bilirubin, excess cholesterol, xenobiotics, trace metals, and other waste products

Question 4

at what total bilirubin levels does jaundice become evident?

Answer 4

2-2.5 mg/dL

Question 5

which form of bilirubin is easily excreted in urine

Answer 5

conjugate bilirubin

Question 6

Black liver always equals

Answer 6

dubin johnson

Question 7

what infectious process can biliary obstruction lead to?

Answer 7

ascending cholangitis

Question 8

What are the components of charcot’s triad (acute cholangitis)

Answer 8

Jaundice
RUQ pain
Fever

Question 9

in neonates what can prolonged hyperbilirubinemia lead to?

Answer 9

neonatal cholestasis

Question 10

What is the single most frequent cause of death from liver disease in early childhood (without surgical intervention)

Answer 10

biliary atresia