Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

GastroIntestinal > Pancreatic Exocrine Function > Flashcards

Pancreatic Exocrine Function Flashcards

1
Q

What is the function of bicarbonate in our body?

A

Bicarbonate is a base

Critical for neutralising acid that comes into the small intestines from the stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the secretion of bicarbonate dependent on?

A

Carbonic anhydrase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is protein digestion initiated by?

A

Pepsin in the stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the two main pancreatic proteases?

A

Trypsin
Chymotrypsin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are pancreatic proteases stored as?

A

Proenzymes
(Trypsinogen and Chymotrypsinogen)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is trypsinogen activated by?

A

Enterokinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What does trypsin activate?

A

Chymotrypsinogen
Additional trypsinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the function of lipases?

A

Hydrolyse triglycerides to monoglycerides and free fatty acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the function of bile salts?

A

Aid triglyceride digestion and absorption of monoglycerides and free fatty acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is fat digestion dependent on?

A

Pancreatic and hepatic secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the function of amylase?

A

Hydrolyses starch to maltose and malotriose and limit dextrins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the major source of amylase?

A

Pancreas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the major source of amylase?

A

Pancreas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the two stages of the stimulation of enzyme secretion?

A

Cephalic Stage - Anticipatory stage, you know a meal is coming and the vagus nerve tells you ( you start to salivate etc) salivary amylase and gastrin produced

Low level stimulus anticipation of a meal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What happens in the intestinal stage of enzyme secretion?

A

Secretin, Cholecystokinin and Gastrin are produced

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is cholecystokinin stimulated by?

A

HCl, Protein and Fats entering the duodenum

17
Q

Where is cholecystokinin produced?

A

I cells of duodenum and jejunum

18
Q

What is the function of cholecystokinin?

A

Gallbladder contraction

Inhibition of gastric acid secretion

Delays gastric emptying

19
Q

What is secretin stimulated by?

A

Low duodenal pH

20
Q

Where is secretin produced?

A

Upper small intestine

21
Q

What is the function of secretin?

A

Pancreatic water and bicarbonate secretion (carrying enzymes)

22
Q

What is gastrin stimulated by?

A

Gastrin distension and irritation

23
Q

Where is gastrin produced?

A

G cells in stomach

24
Q

What is the function of gastrin?

A

HCl secretion (parietal cells) enzyme release (acinar cells)

25
Q

What are symptoms of pancreatic exocrine insufficiency?

A

Maldigestion
Diarrhoea
Steatorrhoea
Weight loss

26
Q

What are consequences of pancreatic exocrine insufficiency?

A

Malnutrition
Osteoporosis
Increased cardiovascular morbidity
Symptom burden

27
Q

What are the steps of a pancreatic function assessment?

A

History, risk factors
Imaging
Faecal elastase
Markers of malnutrition

28
Q

What are steps for treatment of PEI?

A

Pancreatic enzyme replacement therapy
STOP smoking
Bone health assessment
Treat the underlying cause

GastroIntestinal (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions