Pancreatic cancer Flashcards
1
Q
Define pancreatic cancer
A
Malignancy arising from exocrine or endocrine tissue of pancreas
2
Q
Aetiology of pancreatic cancer
A
UNKNOWN
5-10% hereditary - MEN, HNPCC, FAP, Von-Hippel Lindau syndrome
3
Q
Risk factors for pancreatic cancer
5
A
Age Smoking Diabetes mellitus Chronic pancreatitis Dietary - low fruit & veg
4
Q
Epidemiology of pancreatic cancer
incidence, gender, age
A
Increasing incidence
2x more common in MALES
Peak age 60-80yrs
5
Q
Presenting symptoms of pancreatic cancer
general, 7
A
Initial symptoms are often non-specific
Anorexia Malaise Nausea Epigastric pain Weight loss Diabetes mellitus Jaundice
6
Q
Signs of pancreatic cancer on physical examination
5
A
Weight loos Epigastric tenderness or mass Jaundice & palpable gallbladder Hepatomegaly - IF metastatic spread Trousseau’s sign of malignancy - superficial thrombophlebitis
7
Q
Investigations for pancreatic cancer
2
A
Bloods
Imaging
8
Q
Investigations for pancreatic cancer - bloods
5
A
CA19-9 CEA also elevated Obstructive jaundice features: high bilirubin high ALP deranged clotting
9
Q
Investigations for pancreatic cancer - imaging
4
A
US
CT w/without guided biopsy
MRI/MRCP
ERCP - may allow biopsy, bile cytology & stenting
