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Diabetes > Pancrease glucose regulation > Flashcards

Pancrease glucose regulation Flashcards

1
Q

Islets of langerhans

endocrine

A

Insulin
glucagon
somatostatin

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2
Q

Pancreatic Acinar cells

Exocrin cells

A

Digestive enzymes

bicarbonate

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3
Q

Enzymes

A 
Pancreatic amylase
Tripsin
chymotropine
elastase
Pancreatic lipase
Ribonuclease
Deoxyribonulease
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4
Q

What stimulates exocrine secretion

A

Parasympathetic NA
Secretin
Cholecystokinin CKK

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5
Q

What does Cholecystokinin do

A

From intestinal mucosa

* stimulates digestive enzyme secretion in the pancreas

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6
Q

What does secretin do

A

Secretin is released when acid enters duodenum causing the bicarbonate secretion from pancreas

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7
Q

Secretin secretes what

A

bicarbonate

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8
Q

What stimulates exocrine secretion

A

Secretin (acid)

CCK (Protein and fat)

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9
Q

What does islets of Langerhands have?

A 
Alpha cells: 15-20%
Beta Cells: 65-80%
Delta Cells: 3-10%
PP cells: 3-5%
Epsilon Cells: <1%
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10
Q

Alpha cells

A

Glucagon: promotes glycogenolysis

CCK and ACH stimulates

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11
Q

Beta cells

A

Insulin: decrease serum insulin
C peptide
amylin: slow gastric empty, satiety

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12
Q

Delta cells

A

Somatostatin:
Inhibit alpha and beta cells
supresses other GI hormones

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13
Q

PP cells

A

pancreatic polypeptide: Regulate pancreatic secretions

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14
Q

Epsilon cells

A

Grehelin: Increases hunger

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15
Q

What inhibits Glucagon

A

Somatostatin (delta cells)

insulin (beta cells)

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16
Q

Insulin

A

regulates metabolism of carbohydrats an dats by promoting absorption from the blood into myocytes and adipose
Fat storage
Sub Qutaneous

17
Q

C-Peptide is waht

A

when proinsulin in chopped into insulin

18
Q

Inhibit insulin

A

Epi and nore epi

glucagon

19
Q

Release insulin

A

Acetylcholine
Cholecystokinin
GI: GLP-1, GIP

20
Q

Insulin release oscilates

A

3-6min

21
Q

What are most influenced by insulin

A

Myocytes

Adipose

22
Q

What happens when blood glucsoe falls

A

glucagon and catecholamines are released to stimulate glycogenolysis, gluconeogenesis

23
Q

PCOS

A

anovulation
androgen excess
insulin resistence

24
Q

Where do insulinomas come from

A

Beta cells: secret insulin

25
Q

glucagonoma

A

Alpha cells

26
Q

Gastrinoma

A

secretes gastrin

Zollinger ellison syndrome

27
Q

VIPoma

A

dehydration, hypokalemia

28
Q

somatostatin oma

A

Delta cells (woulds secrese pancreatic homenes

29
Q

HOMA

A

Quick test for insulin

Diabetes (3 decks)

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