Oral Hypoglycemic agents

Question 1

Sulfonylureas: MOA

Answer 1

Increase insulin secretion

Question 2

Sulfonylureas disadvantage

Answer 2

Hypoglycemia
Wt gain
inhibit MI
B cell exhaustion

Question 3

Names of sulfonylurease

Answer 3

1st gen: Chlorpropamide
2nd gen: Glipizide
glyburide

Question 4

name of Biguanide

Answer 4

Metformin

Question 5

Biguanides MOA

Answer 5

Decrease helpatic glucose production

Question 6

Biguanide advantage

Answer 6

Wt loss
no hypoglycemia
decrease cardiovascular risk

Question 7

Biguanide disadvangages

Answer 7

GI upsed
B12 deficiency
CKD contradiction

Question 8

Thiazolidinediones drugs

Answer 8

Rosiglitazone

Question 9

Thiazolidinedionase MOA

Answer 9

Increase Peripheral insulin sensitivity

Question 10

Disadvantage to Thiazolidineodinase

Answer 10

Wt gain
Edema, heart failure
bone fracture, LDL CVD

Question 11

Advantages for thiazilidneodinase

Answer 11

No hypoglycemia
Beta cell preservaton
increase HDL

Question 12

Glinides drugs

Answer 12

Repaglinide

Question 13

MOA of Glinides

Answer 13

iincrease insuline secretion

Question 14

advantage of glinides

Answer 14

decrease postprandial glucose

Question 15

Disadvangage of glinides

Answer 15

B cell exhaustion
hypoglycemia
wt gain

Question 16

Alpah glucosidase inhibitors MOA

Answer 16

Decrease intestinal carbohydrate absorption

Question 17

GLIP-1 receptor agonist MOA

Answer 17

Increase insulin secretion
Decrease glucagon
increase satitety

Question 18

GLIP-1 receptor agonist

Answer 18

wt loss,

injectable

Question 19

Amylin mimetics moa

Answer 19

Activates amylin receptors
Reduce glucagon secretion
slow gastric emptying
increased satiety

Question 20

Amylin Mimetics drug

Answer 20

pramlintide

Question 21

DPP-4 inhibitors drug

Answer 21

sitagliptin

Question 22

DPP-4 inhibitor MMA

Answer 22

Inhibit DPP-4
increase endogenous incretions
increase insulin secretion
Decrease glucagon

Question 23

Bile acid sequestrants drug

Answer 23

golesevelam

Question 24

bile acid sequestrants moa

Answer 24

Binds bile acid cholesterol

Question 25

what DM drugs do not have hypoglycemia

Answer 25

Bile acid sequestrants DPP-4 inhibitors Thiazolidinediones Biguanides

Question 26

Insulin

Answer 26

genetic ingeneraion

Question 27

Types of insuline

Answer 27

Regular: short acting SUBQ Rapid Acting: Lispro, aspart Intermediate: Long acting

Question 28

Short acting insulin

Answer 28

Regular: pease 50-120 min | last 508 hours

Question 29

Rapid acting insulin

Answer 29

peak 30-90 min

Question 30

Intermediate acting

Answer 30

Onset 1-3 horus, | Lasts 16-24 hours

Question 31

Ling acting

Answer 31

Slow release over 18-26 hours