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Diabetes > Oral Hypoglycemic agents > Flashcards

Oral Hypoglycemic agents Flashcards

1
Q

Sulfonylureas: MOA

A

Increase insulin secretion

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2
Q

Sulfonylureas disadvantage

A

Hypoglycemia
Wt gain
inhibit MI
B cell exhaustion

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3
Q

Names of sulfonylurease

A

1st gen: Chlorpropamide
2nd gen: Glipizide
glyburide

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4
Q

name of Biguanide

A

Metformin

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5
Q

Biguanides MOA

A

Decrease helpatic glucose production

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6
Q

Biguanide advantage

A

Wt loss
no hypoglycemia
decrease cardiovascular risk

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7
Q

Biguanide disadvangages

A

GI upsed
B12 deficiency
CKD contradiction

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8
Q

Thiazolidinediones drugs

A

Rosiglitazone

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9
Q

Thiazolidinedionase MOA

A

Increase Peripheral insulin sensitivity

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10
Q

Disadvantage to Thiazolidineodinase

A

Wt gain
Edema, heart failure
bone fracture, LDL CVD

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11
Q

Advantages for thiazilidneodinase

A

No hypoglycemia
Beta cell preservaton
increase HDL

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12
Q

Glinides drugs

A

Repaglinide

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13
Q

MOA of Glinides

A

iincrease insuline secretion

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14
Q

advantage of glinides

A

decrease postprandial glucose

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15
Q

Disadvangage of glinides

A

B cell exhaustion
hypoglycemia
wt gain

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16
Q

Alpah glucosidase inhibitors MOA

A

Decrease intestinal carbohydrate absorption

17
Q

GLIP-1 receptor agonist MOA

A

Increase insulin secretion
Decrease glucagon
increase satitety

18
Q

GLIP-1 receptor agonist

A

wt loss,

injectable

19
Q

Amylin mimetics moa

A

Activates amylin receptors
Reduce glucagon secretion
slow gastric emptying
increased satiety

20
Q

Amylin Mimetics drug

A

pramlintide

21
Q

DPP-4 inhibitors drug

A

sitagliptin

22
Q

DPP-4 inhibitor MMA

A

Inhibit DPP-4
increase endogenous incretions
increase insulin secretion
Decrease glucagon

23
Q

Bile acid sequestrants drug

A

golesevelam

24
Q

bile acid sequestrants moa

A

Binds bile acid cholesterol

25
Q

what DM drugs do not have hypoglycemia

A

Bile acid sequestrants
DPP-4 inhibitors
Thiazolidinediones
Biguanides

26
Q

Insulin

A

genetic ingeneraion

27
Q

Types of insuline

A

Regular: short acting SUBQ
Rapid Acting: Lispro, aspart
Intermediate:
Long acting

28
Q

Short acting insulin

A

Regular: pease 50-120 min

last 508 hours

29
Q

Rapid acting insulin

A

peak 30-90 min

30
Q

Intermediate acting

A

Onset 1-3 horus,

Lasts 16-24 hours

31
Q

Ling acting

A

Slow release over 18-26 hours

Diabetes (3 decks)

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