Pancreas Pharm

Question 1

Which cells are destroyed in Type I Diabetes and where in pancreas?

Answer 1

Beta cells in Islet of Langerhan

Question 2

Drug that is rapid acting and is also insulin analog and has shortest duration

Answer 2

Insulin Lispro

Question 3

Intermediate acting insulin which is injected with protamine and crystalline zinc which leads to delayed onset?

Answer 3

NPH Insulin

Question 4

Insulin that acts like human insulin and is short acting injected with zinc crystals and dissociated to form monomer or hexamer?

Answer 4

Regular Insulin

Question 5

Insulin that is used in insulin pump and has very rapid onset?

Answer 5

Insulin Lispro

Question 6

Insulin that can aggregate in neutral pH which leads to slow release and is longest acting?

Answer 6

Insulin Glargine

Question 7

Insulin from short acting to long acting?

Answer 7

Insulin Lispro, Regular insulin, NPH insulin, Insulin Glargine

Question 8

Drug that works as GLP-1 analog (incretin mimetic) leading to glucose dependent insulin release?

Answer 8

Exenatide

Question 9

Drug that works by activating AMP kinase to reduce liver gluconeogenesis and is first choice and belongs to biguanides category?

Answer 9

Metformin

Question 10

Drug that is a alpha glycosidase inhibitor?

Answer 10

Acarbose

Question 11

Drug that is a GLP-1 agonist and works like incretin mimetics

Answer 11

Liraglutide

Question 12

Drugs that inactivate SUR1 receptor in beta cell to depolarize it to release insulin

Answer 12

Glimepiride, Glyburide (Sulfonylurea)

Question 13

Drug that is selective for PPAR-gamma which act on insulin sensitive genes and primarily act on fat

Answer 13

Rosiglitazone (Thiazolidinediones)