Pancreas Path/Pathophys II Flashcards
What are some clinical manifestations of CF?
Obstructive lung disease Pancreatitis Hypertonic sweat Meconium ileus in infants Infertility
Microscopic findings in early cystic fibrosis?
Distended ducts with dark pink secretions
Atrophy of acini with mildly increased fibrous tissue
What are some clinical findings in pediatric cystic fibrosis?
frequent respiratory infections
diarrhea, malabsorption, failure to thrive
frequent dehydration
What is the most common cyst-like lesion in the pancreas?
Pseudocyst
Which neoplastic pancreatic cysts have highest and lowest malignancy potential?
highest: mucinous
lowest: serous
What disease is associated with pseudocysts?
Chronic pancreatitis
Which cystic lesions are potentially malignant?
Mucinous cysts
Intraductal papillary mucinous lesions
Solid pseudopapillary neoplasms
CEA in the serum is indicative of what?
Mucinous cystic neoplasms
What is the best way to diagnose intraductal papillary mucinous neoplasms?
endoscopic retrograde choliangiopancreatography
What is the most common kind of pancreatic cancer?
Ductal adenocarcinoma
Perineural invasion is characteristic of carcinomas
pancreatic
prostatic
start with p
Risk factors for pancreatic cancer
smoking
alcohol / CP
Hereditary pancreatitis
FHx of pancreatic cancer
Clinical features of pancreatic adenocarcinoma?
weight loss
abdominal pain
jaundice
What is a serum marker for adenocarcinoma?
Ca19-9
Where are pancreatic carcinomas located in the gland?
60% head
20% diffuse
